Characterization of a recombinant Sendai virus vector encoding the small ruminant lentivirus gag-P25: antiviral properties in vitro and transgene expression in sheep

Characterization of a recombinant Sendai virus vector encoding the small ruminant lentivirus gag-P25: antiviral properties in vitro and transgene expression in sheep

Abstract Small ruminant lentiviruses (SRLV) cause multisystemic chronic inflammatory disease and significant economic losses in sheep and goats worldwide. However, no vaccines or therapies are currently available. In this study, a recombinant Sendai virus (SeV) vector encoding the SRLV gag-P25 gene...

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Bibliographic Details
Main Authors: Álex Gómez, Idoia Glaria, Irati Moncayola, Irache Echeverría, Javier Arrizabalaga, Ana Rodríguez-Largo, Ignacio de Blas, Delia Lacasta, Estela Pérez, Marta Pérez, Alicia De Diego, Ricardo De-Miguel, Benhur Lee, Lluís Luján, Ramsés Reina
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Veterinary Research
Subjects:
Sendai
viral vector
vaccine
small ruminant lentiviruses
innate immunity
Online Access:https://doi.org/10.1186/s13567-025-01475-2

Internet

https://doi.org/10.1186/s13567-025-01475-2

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