Fetuin-A is also an adipokine
Abstract Fetuin-A (FetA), which impairs insulin action is considered classically as a hepatokine. In patients with Metabolic Syndrome without the confounding of diabetes or cardiovascular diseases, we showed significant increases in both circulating and subcutaneous adipose tissue secreted Fet-A. Fu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2019-03-01
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| Series: | Lipids in Health and Disease |
| Online Access: | http://link.springer.com/article/10.1186/s12944-019-1021-8 |
| _version_ | 1818301494528573440 |
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| author | Ishwarlal Jialal Roma Pahwa |
| author_facet | Ishwarlal Jialal Roma Pahwa |
| author_sort | Ishwarlal Jialal |
| collection | DOAJ |
| description | Abstract Fetuin-A (FetA), which impairs insulin action is considered classically as a hepatokine. In patients with Metabolic Syndrome without the confounding of diabetes or cardiovascular diseases, we showed significant increases in both circulating and subcutaneous adipose tissue secreted Fet-A. Furthermore we showed in mice models increase mRNA and protein following a high fat diet and in a model of metabolic syndrome. This work was recently confirmed by another group of investigators. Hence we propose that Fet-A be considered also as an adipokine. |
| first_indexed | 2024-12-13T05:23:54Z |
| format | Article |
| id | doaj.art-f789d8e85b304ec189109793ee82109f |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-13T05:23:54Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-f789d8e85b304ec189109793ee82109f2022-12-21T23:58:16ZengBMCLipids in Health and Disease1476-511X2019-03-011811210.1186/s12944-019-1021-8Fetuin-A is also an adipokineIshwarlal Jialal0Roma Pahwa1California North-state University College of MedicineNational Cancer Institute, NIHAbstract Fetuin-A (FetA), which impairs insulin action is considered classically as a hepatokine. In patients with Metabolic Syndrome without the confounding of diabetes or cardiovascular diseases, we showed significant increases in both circulating and subcutaneous adipose tissue secreted Fet-A. Furthermore we showed in mice models increase mRNA and protein following a high fat diet and in a model of metabolic syndrome. This work was recently confirmed by another group of investigators. Hence we propose that Fet-A be considered also as an adipokine.http://link.springer.com/article/10.1186/s12944-019-1021-8 |
| spellingShingle | Ishwarlal Jialal Roma Pahwa Fetuin-A is also an adipokine Lipids in Health and Disease |
| title | Fetuin-A is also an adipokine |
| title_full | Fetuin-A is also an adipokine |
| title_fullStr | Fetuin-A is also an adipokine |
| title_full_unstemmed | Fetuin-A is also an adipokine |
| title_short | Fetuin-A is also an adipokine |
| title_sort | fetuin a is also an adipokine |
| url | http://link.springer.com/article/10.1186/s12944-019-1021-8 |
| work_keys_str_mv | AT ishwarlaljialal fetuinaisalsoanadipokine AT romapahwa fetuinaisalsoanadipokine |