Mechanotransduction in the urothelium: ATP signalling and mechanoreceptors
The urothelium, which covers the inner surface of the bladder, is continuously exposed to a complex physical environment where it is stimulated by, and responds to, a wide range of mechanical cues. Mechanically activated ion channels endow the urothelium with functioning in the conversion of mechani...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023066355 |
| _version_ | 1797669939747749888 |
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| author | Xu Li Junwei Hu Ping Yin Lumin Liu Yuelai Chen |
| author_facet | Xu Li Junwei Hu Ping Yin Lumin Liu Yuelai Chen |
| author_sort | Xu Li |
| collection | DOAJ |
| description | The urothelium, which covers the inner surface of the bladder, is continuously exposed to a complex physical environment where it is stimulated by, and responds to, a wide range of mechanical cues. Mechanically activated ion channels endow the urothelium with functioning in the conversion of mechanical stimuli into biochemical events that influence the surface of the urothelium itself as well as suburothelial tissues, including afferent nerve fibres, interstitial cells of Cajal and detrusor smooth muscle cells, to ensure normal urinary function during the cycle of filling and voiding. However, under prolonged and abnormal loading conditions, the urothelial sensory system can become maladaptive, leading to the development of bladder dysfunction. In this review, we summarize developments in the understanding of urothelial mechanotransduction from two perspectives: first, with regard to the functions of urothelial mechanotransduction, particularly stretch-mediated ATP signalling and the regulation of urothelial surface area; and secondly, with regard to the mechanoreceptors present in the urothelium, primarily transient receptor potential channels and mechanosensitive Piezo channels, and the potential pathophysiological role of these channels in the bladder. A more thorough understanding of urothelial mechanotransduction function may inspire the development of new therapeutic strategies for lower urinary tract diseases. |
| first_indexed | 2024-03-11T20:52:17Z |
| format | Article |
| id | doaj.art-f789e18885c5480f809f08b8c1a49025 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-11T20:52:17Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-f789e18885c5480f809f08b8c1a490252023-10-01T05:59:35ZengElsevierHeliyon2405-84402023-09-0199e19427Mechanotransduction in the urothelium: ATP signalling and mechanoreceptorsXu Li0Junwei Hu1Ping Yin2Lumin Liu3Yuelai Chen4Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, ChinaLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, ChinaLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, ChinaLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, ChinaCorresponding author. Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, PR China.; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, ChinaThe urothelium, which covers the inner surface of the bladder, is continuously exposed to a complex physical environment where it is stimulated by, and responds to, a wide range of mechanical cues. Mechanically activated ion channels endow the urothelium with functioning in the conversion of mechanical stimuli into biochemical events that influence the surface of the urothelium itself as well as suburothelial tissues, including afferent nerve fibres, interstitial cells of Cajal and detrusor smooth muscle cells, to ensure normal urinary function during the cycle of filling and voiding. However, under prolonged and abnormal loading conditions, the urothelial sensory system can become maladaptive, leading to the development of bladder dysfunction. In this review, we summarize developments in the understanding of urothelial mechanotransduction from two perspectives: first, with regard to the functions of urothelial mechanotransduction, particularly stretch-mediated ATP signalling and the regulation of urothelial surface area; and secondly, with regard to the mechanoreceptors present in the urothelium, primarily transient receptor potential channels and mechanosensitive Piezo channels, and the potential pathophysiological role of these channels in the bladder. A more thorough understanding of urothelial mechanotransduction function may inspire the development of new therapeutic strategies for lower urinary tract diseases.http://www.sciencedirect.com/science/article/pii/S2405844023066355MechanotransductionUrotheliumBladderTRPPiezo channels |
| spellingShingle | Xu Li Junwei Hu Ping Yin Lumin Liu Yuelai Chen Mechanotransduction in the urothelium: ATP signalling and mechanoreceptors Heliyon Mechanotransduction Urothelium Bladder TRP Piezo channels |
| title | Mechanotransduction in the urothelium: ATP signalling and mechanoreceptors |
| title_full | Mechanotransduction in the urothelium: ATP signalling and mechanoreceptors |
| title_fullStr | Mechanotransduction in the urothelium: ATP signalling and mechanoreceptors |
| title_full_unstemmed | Mechanotransduction in the urothelium: ATP signalling and mechanoreceptors |
| title_short | Mechanotransduction in the urothelium: ATP signalling and mechanoreceptors |
| title_sort | mechanotransduction in the urothelium atp signalling and mechanoreceptors |
| topic | Mechanotransduction Urothelium Bladder TRP Piezo channels |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023066355 |
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