Molecular mechanisms of the juvenile form of Batten disease: important role of MAPK signaling pathways (ERK1/ERK2, JNK and p38) in pathogenesis of the malady

Molecular mechanisms of the juvenile form of Batten disease: important role of MAPK signaling pathways (ERK1/ERK2, JNK and p38) in pathogenesis of the malady

Abstract Background Mutations in the CLN3 gene lead to so far an incurable juvenile-onset neuronal ceroid lipofuscinosis (JNCL) or Batten disease that starts at the age of 4–6 years with a progressive retinopathy leading to blindness. Motor disturbances, epilepsy and dementia manifest during several...

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Bibliographic Details
Main Authors: Elena K. Shematorova, Dmitry G. Shpakovski, Anna D. Chernysheva, George V. Shpakovski
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Biology Direct
Subjects:
Juvenile neuronal ceroid lipofuscinosis (Batten disease)
CLN3
Molecular chaperone
ATP1A1
SRC
EGFR
Online Access:http://link.springer.com/article/10.1186/s13062-018-0212-y

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