Cephalosporin susceptibility of Staphylococcus aureus strains isolated from commercial rabbit and goats farms in Spain
Antimicrobial drug resistance is an important problem that challenges veterinary clinicians to provide effective treatments without further spreading resistance to other animals and people. The most commonly used pharmacodynamic parameter to define potency of antimicrobial drugs is minimum inhibito...
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| Format: | Article |
| Language: | English |
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Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale
2023-05-01
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| Series: | Veterinaria Italiana |
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| Online Access: | https://www.veterinariaitaliana.izs.it/index.php/VetIt/article/view/2241 |
| _version_ | 1797821736098463744 |
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| author | Elena Badillo Elisa Escudero Juan Sebastián Galecio Verónica Hernandis Pedro Marin |
| author_facet | Elena Badillo Elisa Escudero Juan Sebastián Galecio Verónica Hernandis Pedro Marin |
| author_sort | Elena Badillo |
| collection | DOAJ |
| description |
Antimicrobial drug resistance is an important problem that challenges veterinary clinicians to provide effective treatments without further spreading resistance to other animals and people. The most commonly used pharmacodynamic parameter to define potency of antimicrobial drugs is minimum inhibitory concentration (MIC). The aim of this study was to evaluate the antibiotic susceptibility of thirty-six strains of Staphylococcus aureus isolated from dairy goats with mastitis and rabbits with chronic staphylococcosis. Four cephalosporins were tested: cephalexin, cephalotin, cefonicid and ceftiofur. MIC tests were performed according to the microdilution broth method. The calculated values of sensitivity in goats and rabbits were 66.67% and 72.22% for cephalexin, 72.22 % and 94.44% for cefonicid, 77.78% and 94.44% for cephalotin and 77.78% and 100% for ceftiofur, respectively. For all antibiotics, MIC90 of S. aureus from rabbits were lower than MIC90 from goats. These data suggest that more antibiotics are used in goat milk production than in rabbit farming. According to MIC values obtained in this study, ceftiofur and cephalotin may be the best option for treating S. aureus infections in lactating goats. For rabbits, ceftiofur showed lowest MIC values, therefore, it could be an alternative to treatment the infections caused by S. aureus in this species.
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| first_indexed | 2024-03-13T09:57:11Z |
| format | Article |
| id | doaj.art-f78af46847004e45bcd76bbb55413932 |
| institution | Directory Open Access Journal |
| issn | 0505-401X 1828-1427 |
| language | English |
| last_indexed | 2024-03-13T09:57:11Z |
| publishDate | 2023-05-01 |
| publisher | Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale |
| record_format | Article |
| series | Veterinaria Italiana |
| spelling | doaj.art-f78af46847004e45bcd76bbb554139322023-05-23T15:49:49ZengIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. CaporaleVeterinaria Italiana0505-401X1828-14272023-05-0158310.12834/VetIt.2241.16176.1Cephalosporin susceptibility of Staphylococcus aureus strains isolated from commercial rabbit and goats farms in SpainElena Badillo0Elisa Escudero1Juan Sebastián Galecio2Verónica Hernandis3Pedro Marin4Department of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, Campus de Espinardo, 30.071‑Murcia, SpainDepartment of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, Campus de Espinardo, 30.071‑Murcia, SpainDepartment of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, Campus de Espinardo, 30.071‑Murcia, Spain; Escuela de Medicina Veterinaria, Universidad San Francisco de Quito, EC 170157, Cumbayá, EcuadorDepartment of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, Campus de Espinardo, 30.071‑Murcia, SpainDepartment of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, Campus de Espinardo, 30.071‑Murcia, Spain Antimicrobial drug resistance is an important problem that challenges veterinary clinicians to provide effective treatments without further spreading resistance to other animals and people. The most commonly used pharmacodynamic parameter to define potency of antimicrobial drugs is minimum inhibitory concentration (MIC). The aim of this study was to evaluate the antibiotic susceptibility of thirty-six strains of Staphylococcus aureus isolated from dairy goats with mastitis and rabbits with chronic staphylococcosis. Four cephalosporins were tested: cephalexin, cephalotin, cefonicid and ceftiofur. MIC tests were performed according to the microdilution broth method. The calculated values of sensitivity in goats and rabbits were 66.67% and 72.22% for cephalexin, 72.22 % and 94.44% for cefonicid, 77.78% and 94.44% for cephalotin and 77.78% and 100% for ceftiofur, respectively. For all antibiotics, MIC90 of S. aureus from rabbits were lower than MIC90 from goats. These data suggest that more antibiotics are used in goat milk production than in rabbit farming. According to MIC values obtained in this study, ceftiofur and cephalotin may be the best option for treating S. aureus infections in lactating goats. For rabbits, ceftiofur showed lowest MIC values, therefore, it could be an alternative to treatment the infections caused by S. aureus in this species. https://www.veterinariaitaliana.izs.it/index.php/VetIt/article/view/2241CephalosporinsStaphylococcus aureusMinimum inhibitory concentration (MIC)Goats |
| spellingShingle | Elena Badillo Elisa Escudero Juan Sebastián Galecio Verónica Hernandis Pedro Marin Cephalosporin susceptibility of Staphylococcus aureus strains isolated from commercial rabbit and goats farms in Spain Veterinaria Italiana Cephalosporins Staphylococcus aureus Minimum inhibitory concentration (MIC) Goats |
| title | Cephalosporin susceptibility of Staphylococcus aureus strains isolated from commercial rabbit and goats farms in Spain |
| title_full | Cephalosporin susceptibility of Staphylococcus aureus strains isolated from commercial rabbit and goats farms in Spain |
| title_fullStr | Cephalosporin susceptibility of Staphylococcus aureus strains isolated from commercial rabbit and goats farms in Spain |
| title_full_unstemmed | Cephalosporin susceptibility of Staphylococcus aureus strains isolated from commercial rabbit and goats farms in Spain |
| title_short | Cephalosporin susceptibility of Staphylococcus aureus strains isolated from commercial rabbit and goats farms in Spain |
| title_sort | cephalosporin susceptibility of staphylococcus aureus strains isolated from commercial rabbit and goats farms in spain |
| topic | Cephalosporins Staphylococcus aureus Minimum inhibitory concentration (MIC) Goats |
| url | https://www.veterinariaitaliana.izs.it/index.php/VetIt/article/view/2241 |
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