Fabrication of Gelatin-Based Electrospun Composite Fibers for Anti-Bacterial Properties and Protein Adsorption
A major goal of biomimetics is the development of chemical compositions and structures that simulate the extracellular matrix. In this study, gelatin-based electrospun composite fibrous membranes were prepared by electrospinning to generate bone scaffold materials. The gelatin-based multicomponent c...
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MDPI AG
2016-10-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/14/10/192 |
| _version_ | 1798035417235193856 |
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| author | Ya Gao Yingbo Wang Yimin Wang Wenguo Cui |
| author_facet | Ya Gao Yingbo Wang Yimin Wang Wenguo Cui |
| author_sort | Ya Gao |
| collection | DOAJ |
| description | A major goal of biomimetics is the development of chemical compositions and structures that simulate the extracellular matrix. In this study, gelatin-based electrospun composite fibrous membranes were prepared by electrospinning to generate bone scaffold materials. The gelatin-based multicomponent composite fibers were fabricated using co-electrospinning, and the composite fibers of chitosan (CS), gelatin (Gel), hydroxyapatite (HA), and graphene oxide (GO) were successfully fabricated for multi-function characteristics of biomimetic scaffolds. The effect of component concentration on composite fiber morphology, antibacterial properties, and protein adsorption were investigated. Composite fibers exhibited effective antibacterial activity against Staphylococcus aureus and Escherichia coli. The study observed that the composite fibers have higher adsorption capacities of bovine serum albumin (BSA) at pH 5.32–6.00 than at pH 3.90–4.50 or 7.35. The protein adsorption on the surface of the composite fiber increased as the initial BSA concentration increased. The surface of the composite reached adsorption equilibrium at 20 min. These results have specific applications for the development of bone scaffold materials, and broad implications in the field of tissue engineering. |
| first_indexed | 2024-04-11T20:57:54Z |
| format | Article |
| id | doaj.art-f78b86be211a4250bd1aba0c2e332cf9 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T20:57:54Z |
| publishDate | 2016-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-f78b86be211a4250bd1aba0c2e332cf92022-12-22T04:03:38ZengMDPI AGMarine Drugs1660-33972016-10-01141019210.3390/md14100192md14100192Fabrication of Gelatin-Based Electrospun Composite Fibers for Anti-Bacterial Properties and Protein AdsorptionYa Gao0Yingbo Wang1Yimin Wang2Wenguo Cui3College of Chemical Engineering, Xinjiang Normal University, Urumqi 830054, ChinaCollege of Chemical Engineering, Xinjiang Normal University, Urumqi 830054, ChinaCollege of Chemical Engineering, Xinjiang Normal University, Urumqi 830054, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 708 Renmin Road, Suzhou 215006, ChinaA major goal of biomimetics is the development of chemical compositions and structures that simulate the extracellular matrix. In this study, gelatin-based electrospun composite fibrous membranes were prepared by electrospinning to generate bone scaffold materials. The gelatin-based multicomponent composite fibers were fabricated using co-electrospinning, and the composite fibers of chitosan (CS), gelatin (Gel), hydroxyapatite (HA), and graphene oxide (GO) were successfully fabricated for multi-function characteristics of biomimetic scaffolds. The effect of component concentration on composite fiber morphology, antibacterial properties, and protein adsorption were investigated. Composite fibers exhibited effective antibacterial activity against Staphylococcus aureus and Escherichia coli. The study observed that the composite fibers have higher adsorption capacities of bovine serum albumin (BSA) at pH 5.32–6.00 than at pH 3.90–4.50 or 7.35. The protein adsorption on the surface of the composite fiber increased as the initial BSA concentration increased. The surface of the composite reached adsorption equilibrium at 20 min. These results have specific applications for the development of bone scaffold materials, and broad implications in the field of tissue engineering.http://www.mdpi.com/1660-3397/14/10/192electrospinningcomposite fibersantibacterial propertiesprotein adsorption |
| spellingShingle | Ya Gao Yingbo Wang Yimin Wang Wenguo Cui Fabrication of Gelatin-Based Electrospun Composite Fibers for Anti-Bacterial Properties and Protein Adsorption Marine Drugs electrospinning composite fibers antibacterial properties protein adsorption |
| title | Fabrication of Gelatin-Based Electrospun Composite Fibers for Anti-Bacterial Properties and Protein Adsorption |
| title_full | Fabrication of Gelatin-Based Electrospun Composite Fibers for Anti-Bacterial Properties and Protein Adsorption |
| title_fullStr | Fabrication of Gelatin-Based Electrospun Composite Fibers for Anti-Bacterial Properties and Protein Adsorption |
| title_full_unstemmed | Fabrication of Gelatin-Based Electrospun Composite Fibers for Anti-Bacterial Properties and Protein Adsorption |
| title_short | Fabrication of Gelatin-Based Electrospun Composite Fibers for Anti-Bacterial Properties and Protein Adsorption |
| title_sort | fabrication of gelatin based electrospun composite fibers for anti bacterial properties and protein adsorption |
| topic | electrospinning composite fibers antibacterial properties protein adsorption |
| url | http://www.mdpi.com/1660-3397/14/10/192 |
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