Dietary Phosphorus as a Marker of Mineral Metabolism and Progression of Diabetic Kidney Disease
Phosphorus is an essential nutrient that is critically important in the control of cell and tissue function and body homeostasis. Phosphorus excess may result in severe adverse medical consequences. The most apparent is an impact on cardiovascular (CV) disease, mainly through the ability of phosphat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/3/789 |
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| author | Agata Winiarska Iwona Filipska Monika Knysak Tomasz Stompór |
| author_facet | Agata Winiarska Iwona Filipska Monika Knysak Tomasz Stompór |
| author_sort | Agata Winiarska |
| collection | DOAJ |
| description | Phosphorus is an essential nutrient that is critically important in the control of cell and tissue function and body homeostasis. Phosphorus excess may result in severe adverse medical consequences. The most apparent is an impact on cardiovascular (CV) disease, mainly through the ability of phosphate to change the phenotype of vascular smooth muscle cells and its contribution to pathologic vascular, valvular and other soft tissue calcification. Chronic kidney disease (CKD) is the most prevalent chronic disease manifesting with the persistent derangement of phosphate homeostasis. Diabetes and resulting diabetic kidney disease (DKD) remain the leading causes of CKD and end-stage kidney disease (ESRD) worldwide. Mineral and bone disorders of CKD (CKD-MBD), profound derangement of mineral metabolism, develop in the course of the disease and adversely impact on bone health and the CV system. In this review we aimed to discuss the data concerning CKD-MBD in patients with diabetes and to analyze the possible link between hyperphosphatemia, certain biomarkers of CKD-MBD and high dietary phosphate intake on prognosis in patients with diabetes and DKD. We also attempted to clarify if hyperphosphatemia and high phosphorus intake may impact the onset and progression of DKD. Careful analysis of the available literature brings us to the conclusion that, as for today, no clear recommendations based on the firm clinical data can be provided in terms of phosphorus intake aiming to prevent the incidence or progression of diabetic kidney disease. |
| first_indexed | 2024-03-09T06:16:11Z |
| format | Article |
| id | doaj.art-f78de67d461747eb86e6888bf33947a1 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T06:16:11Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-f78de67d461747eb86e6888bf33947a12023-12-03T11:53:02ZengMDPI AGNutrients2072-66432021-02-0113378910.3390/nu13030789Dietary Phosphorus as a Marker of Mineral Metabolism and Progression of Diabetic Kidney DiseaseAgata Winiarska0Iwona Filipska1Monika Knysak2Tomasz Stompór3Department of Nephrology, Hypertension and Internal Medicine, University of Warmia and Mazury in Olsztyn, 10561 Olsztyn, PolandDepartment of Nephrology, Hypertension and Internal Medicine, University of Warmia and Mazury in Olsztyn, 10561 Olsztyn, PolandDepartment of Nephrology, Hypertension and Internal Medicine, University of Warmia and Mazury in Olsztyn, 10561 Olsztyn, PolandDepartment of Nephrology, Hypertension and Internal Medicine, University of Warmia and Mazury in Olsztyn, 10561 Olsztyn, PolandPhosphorus is an essential nutrient that is critically important in the control of cell and tissue function and body homeostasis. Phosphorus excess may result in severe adverse medical consequences. The most apparent is an impact on cardiovascular (CV) disease, mainly through the ability of phosphate to change the phenotype of vascular smooth muscle cells and its contribution to pathologic vascular, valvular and other soft tissue calcification. Chronic kidney disease (CKD) is the most prevalent chronic disease manifesting with the persistent derangement of phosphate homeostasis. Diabetes and resulting diabetic kidney disease (DKD) remain the leading causes of CKD and end-stage kidney disease (ESRD) worldwide. Mineral and bone disorders of CKD (CKD-MBD), profound derangement of mineral metabolism, develop in the course of the disease and adversely impact on bone health and the CV system. In this review we aimed to discuss the data concerning CKD-MBD in patients with diabetes and to analyze the possible link between hyperphosphatemia, certain biomarkers of CKD-MBD and high dietary phosphate intake on prognosis in patients with diabetes and DKD. We also attempted to clarify if hyperphosphatemia and high phosphorus intake may impact the onset and progression of DKD. Careful analysis of the available literature brings us to the conclusion that, as for today, no clear recommendations based on the firm clinical data can be provided in terms of phosphorus intake aiming to prevent the incidence or progression of diabetic kidney disease.https://www.mdpi.com/2072-6643/13/3/789phosphorus intakephosphaturiahyperphosphatemiadiabetic kidney diseasechronic kidney diseaseCKD progression |
| spellingShingle | Agata Winiarska Iwona Filipska Monika Knysak Tomasz Stompór Dietary Phosphorus as a Marker of Mineral Metabolism and Progression of Diabetic Kidney Disease Nutrients phosphorus intake phosphaturia hyperphosphatemia diabetic kidney disease chronic kidney disease CKD progression |
| title | Dietary Phosphorus as a Marker of Mineral Metabolism and Progression of Diabetic Kidney Disease |
| title_full | Dietary Phosphorus as a Marker of Mineral Metabolism and Progression of Diabetic Kidney Disease |
| title_fullStr | Dietary Phosphorus as a Marker of Mineral Metabolism and Progression of Diabetic Kidney Disease |
| title_full_unstemmed | Dietary Phosphorus as a Marker of Mineral Metabolism and Progression of Diabetic Kidney Disease |
| title_short | Dietary Phosphorus as a Marker of Mineral Metabolism and Progression of Diabetic Kidney Disease |
| title_sort | dietary phosphorus as a marker of mineral metabolism and progression of diabetic kidney disease |
| topic | phosphorus intake phosphaturia hyperphosphatemia diabetic kidney disease chronic kidney disease CKD progression |
| url | https://www.mdpi.com/2072-6643/13/3/789 |
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