Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosis
The hallmark of Mycobacterium tuberculosis is its ability to persist for a long-term in host granulomas, in a non-replicating and drug-tolerant state, and later awaken to cause disease. To date, the cellular factors and the molecular mechanisms that mediate entry into the persistence phase are poorl...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-03-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6651/6/3/1002 |
| _version_ | 1798006488794398720 |
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| author | Ambre Sala Patricia Bordes Pierre Genevaux |
| author_facet | Ambre Sala Patricia Bordes Pierre Genevaux |
| author_sort | Ambre Sala |
| collection | DOAJ |
| description | The hallmark of Mycobacterium tuberculosis is its ability to persist for a long-term in host granulomas, in a non-replicating and drug-tolerant state, and later awaken to cause disease. To date, the cellular factors and the molecular mechanisms that mediate entry into the persistence phase are poorly understood. Remarkably, M. tuberculosis possesses a very high number of toxin-antitoxin (TA) systems in its chromosome, 79 in total, regrouping both well-known (68) and novel (11) families, with some of them being strongly induced in drug-tolerant persisters. In agreement with the capacity of stress-responsive TA systems to generate persisters in other bacteria, it has been proposed that activation of TA systems in M. tuberculosis could contribute to its pathogenesis. Herein, we review the current knowledge on the multiple TA families present in this bacterium, their mechanism, and their potential role in physiology and virulence. |
| first_indexed | 2024-04-11T12:56:41Z |
| format | Article |
| id | doaj.art-f78f0bffd656410d865f839516767376 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T12:56:41Z |
| publishDate | 2014-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-f78f0bffd656410d865f8395167673762022-12-22T04:23:04ZengMDPI AGToxins2072-66512014-03-01631002102010.3390/toxins6031002toxins6031002Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosisAmbre Sala0Patricia Bordes1Pierre Genevaux2Laboratoire de Microbiologie et Génétique Moléculaire (LMGM), Centre National de la Recherche Scientifique (CNRS), Université Paul Sabatier, 118 route de Narbonne, Toulouse 31062, FranceLaboratoire de Microbiologie et Génétique Moléculaire (LMGM), Centre National de la Recherche Scientifique (CNRS), Université Paul Sabatier, 118 route de Narbonne, Toulouse 31062, FranceLaboratoire de Microbiologie et Génétique Moléculaire (LMGM), Centre National de la Recherche Scientifique (CNRS), Université Paul Sabatier, 118 route de Narbonne, Toulouse 31062, FranceThe hallmark of Mycobacterium tuberculosis is its ability to persist for a long-term in host granulomas, in a non-replicating and drug-tolerant state, and later awaken to cause disease. To date, the cellular factors and the molecular mechanisms that mediate entry into the persistence phase are poorly understood. Remarkably, M. tuberculosis possesses a very high number of toxin-antitoxin (TA) systems in its chromosome, 79 in total, regrouping both well-known (68) and novel (11) families, with some of them being strongly induced in drug-tolerant persisters. In agreement with the capacity of stress-responsive TA systems to generate persisters in other bacteria, it has been proposed that activation of TA systems in M. tuberculosis could contribute to its pathogenesis. Herein, we review the current knowledge on the multiple TA families present in this bacterium, their mechanism, and their potential role in physiology and virulence.http://www.mdpi.com/2072-6651/6/3/1002toxin-antitoxinsmolecular chaperonesproteasespersistence |
| spellingShingle | Ambre Sala Patricia Bordes Pierre Genevaux Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosis Toxins toxin-antitoxins molecular chaperones proteases persistence |
| title | Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosis |
| title_full | Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosis |
| title_fullStr | Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosis |
| title_full_unstemmed | Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosis |
| title_short | Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosis |
| title_sort | multiple toxin antitoxin systems in mycobacterium tuberculosis |
| topic | toxin-antitoxins molecular chaperones proteases persistence |
| url | http://www.mdpi.com/2072-6651/6/3/1002 |
| work_keys_str_mv | AT ambresala multipletoxinantitoxinsystemsinmycobacteriumtuberculosis AT patriciabordes multipletoxinantitoxinsystemsinmycobacteriumtuberculosis AT pierregenevaux multipletoxinantitoxinsystemsinmycobacteriumtuberculosis |