Factors influencing C-reactive protein status on admission in neonates after birth
Abstract Objective To explore the factors influencing C-reactive protein (CRP) status in neonates on admission after birth. Methods 820 newborns born and hospitalized at Xiangya Hospital of Central South University from Jan. 2020 to Dec. 2020 were retrospectively analyzed. Maternal medical history a...
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Pediatrics |
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| Online Access: | https://doi.org/10.1186/s12887-024-04583-8 |
| _version_ | 1827326212644536320 |
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| author | Chuanding Cao Shuo Wang Yang Liu Shaojie Yue Mingjie Wang Xiaohe Yu Ying Ding Mei Lv Keren Fang Meiyan Chu Zhengchang Liao |
| author_facet | Chuanding Cao Shuo Wang Yang Liu Shaojie Yue Mingjie Wang Xiaohe Yu Ying Ding Mei Lv Keren Fang Meiyan Chu Zhengchang Liao |
| author_sort | Chuanding Cao |
| collection | DOAJ |
| description | Abstract Objective To explore the factors influencing C-reactive protein (CRP) status in neonates on admission after birth. Methods 820 newborns born and hospitalized at Xiangya Hospital of Central South University from Jan. 2020 to Dec. 2020 were retrospectively analyzed. Maternal medical history and medication use during pregnancy, neonatal demographic information and status at birth were collected through the electronic medical record system. Statistical software was used to analyze the possible relationship between perinatal factors and CRP on admission after birth. Results A total of 820 neonates were analyzed, including 463 males and 357 females with a mean gestational age (GA) of 36.07 ± 3.30 weeks. (1) Multifactor Logistic regression analysis: larger GA (OR: 1.13, 95%CI: 1.00-1.28, P = 0.042), premature rupture of membranes (PROM) ≥ 18 h (OR: 2.39, 95%CI: 1.35–4.23, P = 0.003) and maternal autoimmune diseases (OR: 5.30, 95%CI: 2.15–13.07, P < 0.001) were independent risk factors for CRP ≥ 8 mg/L. Cesarean delivery (OR 0.40, 95%CI: 0.26–0.60, P < 0.001) was independent protective factor for CRP ≥ 8 mg/L. (2) Threshold effect analysis: A non-linear relationship was found between GA and CRP. When GA is less than 33.9 weeks, the risk of CRP ≥ 8 mg/L was reduced by 28% with one week increased (P < 0.001), and when GA is more than 33.9 weeks, the risk of CRP ≥ 8 mg/L was increased by 61% with one week increased (P < 0.001). Conclusions GA, PROM, maternal autoimmune diseases and cesarean delivery were all independent influences neonatal CRP ≥ 8 mg/L on admission, and there was a nonlinear relationship between GA and neonatal CRP ≥ 8 mg/L on admission. |
| first_indexed | 2024-03-07T14:41:19Z |
| format | Article |
| id | doaj.art-f7912771422c469c949aa0ce876c770f |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-03-07T14:41:19Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-f7912771422c469c949aa0ce876c770f2024-03-05T20:22:32ZengBMCBMC Pediatrics1471-24312024-02-012411910.1186/s12887-024-04583-8Factors influencing C-reactive protein status on admission in neonates after birthChuanding Cao0Shuo Wang1Yang Liu2Shaojie Yue3Mingjie Wang4Xiaohe Yu5Ying Ding6Mei Lv7Keren Fang8Meiyan Chu9Zhengchang Liao10Department of Neonatology, Xiangya Hospital, Central South UniversityDepartment of Neonatology, Xiangya Hospital, Central South UniversityDepartment of Neonatology, Xiangya Hospital, Central South UniversityDepartment of Neonatology, Xiangya Hospital, Central South UniversityDepartment of Neonatology, Xiangya Hospital, Central South UniversityDepartment of Neonatology, Xiangya Hospital, Central South UniversityDepartment of Neonatology, Xiangya Hospital, Central South UniversityDepartment of Neonatology, Xiangya Hospital, Central South UniversityDepartment of Neonatology, Xiangya Hospital, Central South UniversityDepartment of Neonatology, Xiangya Hospital, Central South UniversityDepartment of Neonatology, Xiangya Hospital, Central South UniversityAbstract Objective To explore the factors influencing C-reactive protein (CRP) status in neonates on admission after birth. Methods 820 newborns born and hospitalized at Xiangya Hospital of Central South University from Jan. 2020 to Dec. 2020 were retrospectively analyzed. Maternal medical history and medication use during pregnancy, neonatal demographic information and status at birth were collected through the electronic medical record system. Statistical software was used to analyze the possible relationship between perinatal factors and CRP on admission after birth. Results A total of 820 neonates were analyzed, including 463 males and 357 females with a mean gestational age (GA) of 36.07 ± 3.30 weeks. (1) Multifactor Logistic regression analysis: larger GA (OR: 1.13, 95%CI: 1.00-1.28, P = 0.042), premature rupture of membranes (PROM) ≥ 18 h (OR: 2.39, 95%CI: 1.35–4.23, P = 0.003) and maternal autoimmune diseases (OR: 5.30, 95%CI: 2.15–13.07, P < 0.001) were independent risk factors for CRP ≥ 8 mg/L. Cesarean delivery (OR 0.40, 95%CI: 0.26–0.60, P < 0.001) was independent protective factor for CRP ≥ 8 mg/L. (2) Threshold effect analysis: A non-linear relationship was found between GA and CRP. When GA is less than 33.9 weeks, the risk of CRP ≥ 8 mg/L was reduced by 28% with one week increased (P < 0.001), and when GA is more than 33.9 weeks, the risk of CRP ≥ 8 mg/L was increased by 61% with one week increased (P < 0.001). Conclusions GA, PROM, maternal autoimmune diseases and cesarean delivery were all independent influences neonatal CRP ≥ 8 mg/L on admission, and there was a nonlinear relationship between GA and neonatal CRP ≥ 8 mg/L on admission.https://doi.org/10.1186/s12887-024-04583-8NeonatesC reactive proteinPerinatal factorsGestational ageSmooth curve fitting |
| spellingShingle | Chuanding Cao Shuo Wang Yang Liu Shaojie Yue Mingjie Wang Xiaohe Yu Ying Ding Mei Lv Keren Fang Meiyan Chu Zhengchang Liao Factors influencing C-reactive protein status on admission in neonates after birth BMC Pediatrics Neonates C reactive protein Perinatal factors Gestational age Smooth curve fitting |
| title | Factors influencing C-reactive protein status on admission in neonates after birth |
| title_full | Factors influencing C-reactive protein status on admission in neonates after birth |
| title_fullStr | Factors influencing C-reactive protein status on admission in neonates after birth |
| title_full_unstemmed | Factors influencing C-reactive protein status on admission in neonates after birth |
| title_short | Factors influencing C-reactive protein status on admission in neonates after birth |
| title_sort | factors influencing c reactive protein status on admission in neonates after birth |
| topic | Neonates C reactive protein Perinatal factors Gestational age Smooth curve fitting |
| url | https://doi.org/10.1186/s12887-024-04583-8 |
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