The exercise pressor reflex in hypertension
The cardiovascular response to physical exercise is abnormally exaggerated in hypertension. Since such responses potentially increase the risk for adverse cardiovascular events, it is clinically important to elucidate the cause of this cardiovascular hyper-excitability in this disease. Even if blood...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Japanese Society of Physical Fitness and Sports Medicine
2016-11-01
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| Series: | Journal of Physical Fitness and Sports Medicine |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jpfsm/5/5/5_339/_pdf/-char/en |
| _version_ | 1819097569566916608 |
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| author | Masaki Mizuno Jere H. Mitchell Scott A. Smith |
| author_facet | Masaki Mizuno Jere H. Mitchell Scott A. Smith |
| author_sort | Masaki Mizuno |
| collection | DOAJ |
| description | The cardiovascular response to physical exercise is abnormally exaggerated in hypertension. Since such responses potentially increase the risk for adverse cardiovascular events, it is clinically important to elucidate the cause of this cardiovascular hyper-excitability in this disease. Even if blood pressure is normal at rest, individuals displaying a heightened blood pressure response to exercise are more likely to develop future hypertension. Therefore, early detection of this abnormal circulatory response to physical activity could lead to the early treatment as well as prevention of hypertension. Much evidence suggests that the abnormal exercise pressor reflex (EPR; a reflex originating in exercising skeletal muscle) significantly contributes to the generation of the enhanced circulatory responses in this disease. In addition, it has been demonstrated that the EPR dysfunction is mediated by both mechanically-sensitive fibers associated with the muscle mechanoreflex and chemically-sensitive fibers associated with the muscle metaboreflex. This review focuses on the underlying mechanisms for this overactive EPR function in hypertension. Specifically, updates on our current understanding of the EPR in this disease as well as experimental models used to examine this reflex are presented. |
| first_indexed | 2024-12-22T00:17:11Z |
| format | Article |
| id | doaj.art-f791fbba2d814ef581936d14c073a2a7 |
| institution | Directory Open Access Journal |
| issn | 2186-8131 2186-8123 |
| language | English |
| last_indexed | 2024-12-22T00:17:11Z |
| publishDate | 2016-11-01 |
| publisher | Japanese Society of Physical Fitness and Sports Medicine |
| record_format | Article |
| series | Journal of Physical Fitness and Sports Medicine |
| spelling | doaj.art-f791fbba2d814ef581936d14c073a2a72022-12-21T18:45:16ZengJapanese Society of Physical Fitness and Sports MedicineJournal of Physical Fitness and Sports Medicine2186-81312186-81232016-11-015533934710.7600/jpfsm.5.339jpfsmThe exercise pressor reflex in hypertensionMasaki Mizuno0Jere H. Mitchell1Scott A. Smith2Department of Health Care Sciences, University of Texas Southwestern Medical CenterInternal Medicine, University of Texas Southwestern Medical CenterDepartment of Health Care Sciences, University of Texas Southwestern Medical CenterThe cardiovascular response to physical exercise is abnormally exaggerated in hypertension. Since such responses potentially increase the risk for adverse cardiovascular events, it is clinically important to elucidate the cause of this cardiovascular hyper-excitability in this disease. Even if blood pressure is normal at rest, individuals displaying a heightened blood pressure response to exercise are more likely to develop future hypertension. Therefore, early detection of this abnormal circulatory response to physical activity could lead to the early treatment as well as prevention of hypertension. Much evidence suggests that the abnormal exercise pressor reflex (EPR; a reflex originating in exercising skeletal muscle) significantly contributes to the generation of the enhanced circulatory responses in this disease. In addition, it has been demonstrated that the EPR dysfunction is mediated by both mechanically-sensitive fibers associated with the muscle mechanoreflex and chemically-sensitive fibers associated with the muscle metaboreflex. This review focuses on the underlying mechanisms for this overactive EPR function in hypertension. Specifically, updates on our current understanding of the EPR in this disease as well as experimental models used to examine this reflex are presented.https://www.jstage.jst.go.jp/article/jpfsm/5/5/5_339/_pdf/-char/enblood pressureheart ratesympathetic nerve activityexercisehypertension |
| spellingShingle | Masaki Mizuno Jere H. Mitchell Scott A. Smith The exercise pressor reflex in hypertension Journal of Physical Fitness and Sports Medicine blood pressure heart rate sympathetic nerve activity exercise hypertension |
| title | The exercise pressor reflex in hypertension |
| title_full | The exercise pressor reflex in hypertension |
| title_fullStr | The exercise pressor reflex in hypertension |
| title_full_unstemmed | The exercise pressor reflex in hypertension |
| title_short | The exercise pressor reflex in hypertension |
| title_sort | exercise pressor reflex in hypertension |
| topic | blood pressure heart rate sympathetic nerve activity exercise hypertension |
| url | https://www.jstage.jst.go.jp/article/jpfsm/5/5/5_339/_pdf/-char/en |
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