An intelligent responsive macrophage cell membrane-camouflaged mesoporous silicon nanorod drug delivery system for precise targeted therapy of tumors
Abstract Macrophage cell membrane-camouflaged nanocarriers can effectively reduce immune cell clearance and actively target tumors. In this study, a macrophage cell membrane-camouflaged mesoporous silica nanorod (MSNR)-based antitumor drug carrier equipped with a cationic polymer layer was developed...
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-021-01082-1 |
| _version_ | 1811277601238417408 |
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| author | Minghua Li Xiaolong Gao Chao Lin Aijun Shen Jing Luo Qiongqiong Ji Jiaqi Wu Peijun Wang |
| author_facet | Minghua Li Xiaolong Gao Chao Lin Aijun Shen Jing Luo Qiongqiong Ji Jiaqi Wu Peijun Wang |
| author_sort | Minghua Li |
| collection | DOAJ |
| description | Abstract Macrophage cell membrane-camouflaged nanocarriers can effectively reduce immune cell clearance and actively target tumors. In this study, a macrophage cell membrane-camouflaged mesoporous silica nanorod (MSNR)-based antitumor drug carrier equipped with a cationic polymer layer was developed. As drug carriers, these MSNRs were loaded with the thermosensitive phase change material L-menthol (LM), the chemotherapy drug doxorubicin (DOX) and the fluorescent molecule indocyanine green (ICG). The rod-like shape of the MSNRs was shown to enhance the penetration of the drug carriers to tumors. In the weakly acidic tumor microenvironment, the cationic polymer exhibited a proton sponge effect to trigger macrophage cell membrane coating detachment, promoting tumor cell uptake. Following nanocarrier uptake, ICG is heated by near-infrared (NIR) irradiation to make LM undergo a phase transition to release DOX and generate a synergistic effect of thermochemotherapy which kills tumor cells and inhibits tumor growth together with reactive oxygen species (ROS) produced by ICG. Overall, this nanohybrid drug delivery system demonstrates an intelligent cascade response, leads to tissue-cell specific targeting and improves drug release accuracy, thus proving to be an effective cancer therapy. Graphical Abstract |
| first_indexed | 2024-04-13T00:19:40Z |
| format | Article |
| id | doaj.art-f7939917e5994b55811d8b666ca71cb9 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-13T00:19:40Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-f7939917e5994b55811d8b666ca71cb92022-12-22T03:10:50ZengBMCJournal of Nanobiotechnology1477-31552021-10-0119111610.1186/s12951-021-01082-1An intelligent responsive macrophage cell membrane-camouflaged mesoporous silicon nanorod drug delivery system for precise targeted therapy of tumorsMinghua Li0Xiaolong Gao1Chao Lin2Aijun Shen3Jing Luo4Qiongqiong Ji5Jiaqi Wu6Peijun Wang7Department of Radiology, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Radiology, Luodian HospitalInstitute for Translational Medicine, Shanghai East Hospital, Institute for Biomedical Engineering and Nanoscience, School of Medicine, Tongji UniversityDepartment of Radiology, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Radiology, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Radiology, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Radiology, Tongji Hospital, School of Medicine, Tongji UniversityDepartment of Radiology, Tongji Hospital, School of Medicine, Tongji UniversityAbstract Macrophage cell membrane-camouflaged nanocarriers can effectively reduce immune cell clearance and actively target tumors. In this study, a macrophage cell membrane-camouflaged mesoporous silica nanorod (MSNR)-based antitumor drug carrier equipped with a cationic polymer layer was developed. As drug carriers, these MSNRs were loaded with the thermosensitive phase change material L-menthol (LM), the chemotherapy drug doxorubicin (DOX) and the fluorescent molecule indocyanine green (ICG). The rod-like shape of the MSNRs was shown to enhance the penetration of the drug carriers to tumors. In the weakly acidic tumor microenvironment, the cationic polymer exhibited a proton sponge effect to trigger macrophage cell membrane coating detachment, promoting tumor cell uptake. Following nanocarrier uptake, ICG is heated by near-infrared (NIR) irradiation to make LM undergo a phase transition to release DOX and generate a synergistic effect of thermochemotherapy which kills tumor cells and inhibits tumor growth together with reactive oxygen species (ROS) produced by ICG. Overall, this nanohybrid drug delivery system demonstrates an intelligent cascade response, leads to tissue-cell specific targeting and improves drug release accuracy, thus proving to be an effective cancer therapy. Graphical Abstracthttps://doi.org/10.1186/s12951-021-01082-1Mesoporous silicon nanorodsMacrophage cell membraneDrug deliveryPrecision tumor therapy |
| spellingShingle | Minghua Li Xiaolong Gao Chao Lin Aijun Shen Jing Luo Qiongqiong Ji Jiaqi Wu Peijun Wang An intelligent responsive macrophage cell membrane-camouflaged mesoporous silicon nanorod drug delivery system for precise targeted therapy of tumors Journal of Nanobiotechnology Mesoporous silicon nanorods Macrophage cell membrane Drug delivery Precision tumor therapy |
| title | An intelligent responsive macrophage cell membrane-camouflaged mesoporous silicon nanorod drug delivery system for precise targeted therapy of tumors |
| title_full | An intelligent responsive macrophage cell membrane-camouflaged mesoporous silicon nanorod drug delivery system for precise targeted therapy of tumors |
| title_fullStr | An intelligent responsive macrophage cell membrane-camouflaged mesoporous silicon nanorod drug delivery system for precise targeted therapy of tumors |
| title_full_unstemmed | An intelligent responsive macrophage cell membrane-camouflaged mesoporous silicon nanorod drug delivery system for precise targeted therapy of tumors |
| title_short | An intelligent responsive macrophage cell membrane-camouflaged mesoporous silicon nanorod drug delivery system for precise targeted therapy of tumors |
| title_sort | intelligent responsive macrophage cell membrane camouflaged mesoporous silicon nanorod drug delivery system for precise targeted therapy of tumors |
| topic | Mesoporous silicon nanorods Macrophage cell membrane Drug delivery Precision tumor therapy |
| url | https://doi.org/10.1186/s12951-021-01082-1 |
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