PET measurement of longitudinal amyloid load identifies the earliest stages of amyloid-beta accumulation during Alzheimer's disease progression in Down syndrome

PET measurement of longitudinal amyloid load identifies the earliest stages of amyloid-beta accumulation during Alzheimer's disease progression in Down syndrome

Introduction: Adults with Down syndrome (DS) are predisposed to Alzheimer's disease (AD) and reveal early amyloid beta (Aβ) pathology in the brain. Positron emission tomography (PET) provides an in vivo measure of Aβ throughout the AD continuum. Due to the high prevalence of AD in DS, there is...

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Bibliographic Details
Main Authors: Matthew D. Zammit, Dana L. Tudorascu, Charles M. Laymon, Sigan L. Hartley, Shahid H. Zaman, Beau M. Ances, Sterling C. Johnson, Charles K. Stone, Chester A. Mathis, William E. Klunk, Ann D. Cohen, Benjamin L. Handen, Bradley T. Christian
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:NeuroImage
Subjects:
Down syndrome
Amyloid PET
Alzheimer's disease
Longitudinal
Subthreshold amyloid
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811921000057

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