Valproic Acid Enhances Reprogramming Efficiency and Neuronal Differentiation on Small Molecules Staged-Induction Neural Stem Cells: Suggested Role of mTOR Signaling

Valproic Acid Enhances Reprogramming Efficiency and Neuronal Differentiation on Small Molecules Staged-Induction Neural Stem Cells: Suggested Role of mTOR Signaling

Inducing somatic cells into neural stem cells (iNSCs) in specific ways provides a new cell therapy in a variety of neurological diseases. In the past, iNSCs were generated by transcription factors which increased the risk of mutagenesis, tumor formations, and immune reactions by viral transduction v...

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Bibliographic Details
Main Authors: Qingrui Duan, Siyi Li, Xinrui Wen, Gavin Sunnassee, Jian Chen, Sheng Tan, Yang Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Neuroscience
Subjects:
neural stem cells
VPA
mTOR signaling
small molecule
reprogramming
stage-induction
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00867/full

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