Anti-Inflammatory and Anti-Catabolic Effects of Creatine Supplementation: A Brief Review
It is well established that creatine supplementation, primarily when combined with resistance training, significantly increases measures of muscle mass and performance (primarily strength). Emerging research also indicates that creatine supplementation may have favorable effects on measures of bone...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/3/544 |
| _version_ | 1797485660060254208 |
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| author | Dean M. Cordingley Stephen M. Cornish Darren G. Candow |
| author_facet | Dean M. Cordingley Stephen M. Cornish Darren G. Candow |
| author_sort | Dean M. Cordingley |
| collection | DOAJ |
| description | It is well established that creatine supplementation, primarily when combined with resistance training, significantly increases measures of muscle mass and performance (primarily strength). Emerging research also indicates that creatine supplementation may have favorable effects on measures of bone biology. These anabolic adaptations may be related to creatine influencing cellular hydration status, high-energy phosphate metabolism, growth factors, muscle protein kinetics, and the bone remodeling process. Accumulating research also suggests that creatine supplementation has anti-inflammatory and anti-catabolic properties, which may help create a favorable environment for muscle and bone accretion and recovery from exercise. Creatine supplementation has the ability to decrease markers of inflammation and possibly attenuate cancerous tumor growth progression. From a musculoskeletal perspective, there is some evidence to show that creatine supplementation reduces measures of muscle protein catabolism (primarily in males) and bone resorption when combined with resistance training. The purpose of this brief review is to summarize the current body of literature examining the potential anti-inflammatory and anti-catabolic effects of creatine supplementation across various research populations. |
| first_indexed | 2024-03-09T23:21:53Z |
| format | Article |
| id | doaj.art-f794886eb6574505bd31e2a0d9aeb08d |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T23:21:53Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-f794886eb6574505bd31e2a0d9aeb08d2023-11-23T17:25:30ZengMDPI AGNutrients2072-66432022-01-0114354410.3390/nu14030544Anti-Inflammatory and Anti-Catabolic Effects of Creatine Supplementation: A Brief ReviewDean M. Cordingley0Stephen M. Cornish1Darren G. Candow2Applied Health Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, CanadaApplied Health Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, CanadaFaculty of Kinesiology and Health Studies, University of Regina, Regina, SK S4S 0A2, CanadaIt is well established that creatine supplementation, primarily when combined with resistance training, significantly increases measures of muscle mass and performance (primarily strength). Emerging research also indicates that creatine supplementation may have favorable effects on measures of bone biology. These anabolic adaptations may be related to creatine influencing cellular hydration status, high-energy phosphate metabolism, growth factors, muscle protein kinetics, and the bone remodeling process. Accumulating research also suggests that creatine supplementation has anti-inflammatory and anti-catabolic properties, which may help create a favorable environment for muscle and bone accretion and recovery from exercise. Creatine supplementation has the ability to decrease markers of inflammation and possibly attenuate cancerous tumor growth progression. From a musculoskeletal perspective, there is some evidence to show that creatine supplementation reduces measures of muscle protein catabolism (primarily in males) and bone resorption when combined with resistance training. The purpose of this brief review is to summarize the current body of literature examining the potential anti-inflammatory and anti-catabolic effects of creatine supplementation across various research populations.https://www.mdpi.com/2072-6643/14/3/544cytokinescanceroxidative stressmuscle proteinbone catabolism |
| spellingShingle | Dean M. Cordingley Stephen M. Cornish Darren G. Candow Anti-Inflammatory and Anti-Catabolic Effects of Creatine Supplementation: A Brief Review Nutrients cytokines cancer oxidative stress muscle protein bone catabolism |
| title | Anti-Inflammatory and Anti-Catabolic Effects of Creatine Supplementation: A Brief Review |
| title_full | Anti-Inflammatory and Anti-Catabolic Effects of Creatine Supplementation: A Brief Review |
| title_fullStr | Anti-Inflammatory and Anti-Catabolic Effects of Creatine Supplementation: A Brief Review |
| title_full_unstemmed | Anti-Inflammatory and Anti-Catabolic Effects of Creatine Supplementation: A Brief Review |
| title_short | Anti-Inflammatory and Anti-Catabolic Effects of Creatine Supplementation: A Brief Review |
| title_sort | anti inflammatory and anti catabolic effects of creatine supplementation a brief review |
| topic | cytokines cancer oxidative stress muscle protein bone catabolism |
| url | https://www.mdpi.com/2072-6643/14/3/544 |
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