Fecal microbiota transplantation—could stool donors’ and receptors’ diet be the key to future success?

Fecal microbiota transplantation (FMT) is indicated in many countries for patients with multiple recurrences of Clostridioides difficile infection (CDI) for whom appropriate antibiotic treatments have failed. Donor selection is a demanding and rigorous process in view of the implementation of FMT pr...

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Main Authors: Rita Silva, Liliana Dinis, Arnau Peris, Luís Novais, Conceição Calhau, Diogo Pestana, Cláudia Marques
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Gastroenterology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fgstr.2023.1270899/full
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author Rita Silva
Rita Silva
Liliana Dinis
Liliana Dinis
Liliana Dinis
Arnau Peris
Luís Novais
Conceição Calhau
Diogo Pestana
Diogo Pestana
Cláudia Marques
Cláudia Marques
author_facet Rita Silva
Rita Silva
Liliana Dinis
Liliana Dinis
Liliana Dinis
Arnau Peris
Luís Novais
Conceição Calhau
Diogo Pestana
Diogo Pestana
Cláudia Marques
Cláudia Marques
author_sort Rita Silva
collection DOAJ
description Fecal microbiota transplantation (FMT) is indicated in many countries for patients with multiple recurrences of Clostridioides difficile infection (CDI) for whom appropriate antibiotic treatments have failed. Donor selection is a demanding and rigorous process in view of the implementation of FMT programs worldwide. One of the most noteworthy factors that has been shown to affect FMT outcomes is the microbial diversity of the stool donor. A detailed assessment of the donor’s microbiota is crucial, as the microbiota is complex, dynamic, and resilient, and a healthy microbiota has several dimensions in addition to the absence of pathogens. Diet is one of the most important factors that modulates the composition and function of the gut microbiome (GM) and has a critical role in orchestrating the host–microbiota crosstalk throughout life. The diversity of the human GM seems to be related to variations in dietary patterns. Currently, the dietary patterns of stool donors and receptors are not taken into consideration in any way for FMT. In this study, we reflect on the importance of including this type of assessment in the stool donor screening process and knowing the impact of diet on the GM, as well as the importance of monitoring receptors’ diet to ensure the engraftment of the transplanted microbiota.
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spelling doaj.art-f79a766a59f94e6da336ee8832cddc372024-08-03T02:01:07ZengFrontiers Media S.A.Frontiers in Gastroenterology2813-11692023-11-01210.3389/fgstr.2023.12708991270899Fecal microbiota transplantation—could stool donors’ and receptors’ diet be the key to future success?Rita Silva0Rita Silva1Liliana Dinis2Liliana Dinis3Liliana Dinis4Arnau Peris5Luís Novais6Conceição Calhau7Diogo Pestana8Diogo Pestana9Cláudia Marques10Cláudia Marques11Nutrition & Metabolism Department, CINTESIS@RISE, NOVA Medical School, Faculdade de Ciências Médicas (NMS|FCM), Universidade Nova de Lisboa, Lisboa, PortugalYourBiome®, Évora, PortugalNutrition & Metabolism Department, CINTESIS@RISE, NOVA Medical School, Faculdade de Ciências Médicas (NMS|FCM), Universidade Nova de Lisboa, Lisboa, PortugalYourBiome®, Évora, PortugalCHRC—Comprehensive Health Research Centre, NOVA Medical School, Faculdade de Ciências Médicas (NMS|FCM), Universidade Nova de Lisboa, Lisboa, PortugalYourBiome®, Évora, PortugalLNMD—Laboratory of Neurogastrenterology and Motility, Lisboa, PortugalNutrition & Metabolism Department, CINTESIS@RISE, NOVA Medical School, Faculdade de Ciências Médicas (NMS|FCM), Universidade Nova de Lisboa, Lisboa, PortugalNutrition & Metabolism Department, CINTESIS@RISE, NOVA Medical School, Faculdade de Ciências Médicas (NMS|FCM), Universidade Nova de Lisboa, Lisboa, PortugalYourBiome®, Évora, PortugalNutrition & Metabolism Department, CINTESIS@RISE, NOVA Medical School, Faculdade de Ciências Médicas (NMS|FCM), Universidade Nova de Lisboa, Lisboa, PortugalYourBiome®, Évora, PortugalFecal microbiota transplantation (FMT) is indicated in many countries for patients with multiple recurrences of Clostridioides difficile infection (CDI) for whom appropriate antibiotic treatments have failed. Donor selection is a demanding and rigorous process in view of the implementation of FMT programs worldwide. One of the most noteworthy factors that has been shown to affect FMT outcomes is the microbial diversity of the stool donor. A detailed assessment of the donor’s microbiota is crucial, as the microbiota is complex, dynamic, and resilient, and a healthy microbiota has several dimensions in addition to the absence of pathogens. Diet is one of the most important factors that modulates the composition and function of the gut microbiome (GM) and has a critical role in orchestrating the host–microbiota crosstalk throughout life. The diversity of the human GM seems to be related to variations in dietary patterns. Currently, the dietary patterns of stool donors and receptors are not taken into consideration in any way for FMT. In this study, we reflect on the importance of including this type of assessment in the stool donor screening process and knowing the impact of diet on the GM, as well as the importance of monitoring receptors’ diet to ensure the engraftment of the transplanted microbiota.https://www.frontiersin.org/articles/10.3389/fgstr.2023.1270899/fulldietfecal microbiota transplantationFMT receptorsgut microbiotastool donors
spellingShingle Rita Silva
Rita Silva
Liliana Dinis
Liliana Dinis
Liliana Dinis
Arnau Peris
Luís Novais
Conceição Calhau
Diogo Pestana
Diogo Pestana
Cláudia Marques
Cláudia Marques
Fecal microbiota transplantation—could stool donors’ and receptors’ diet be the key to future success?
Frontiers in Gastroenterology
diet
fecal microbiota transplantation
FMT receptors
gut microbiota
stool donors
title Fecal microbiota transplantation—could stool donors’ and receptors’ diet be the key to future success?
title_full Fecal microbiota transplantation—could stool donors’ and receptors’ diet be the key to future success?
title_fullStr Fecal microbiota transplantation—could stool donors’ and receptors’ diet be the key to future success?
title_full_unstemmed Fecal microbiota transplantation—could stool donors’ and receptors’ diet be the key to future success?
title_short Fecal microbiota transplantation—could stool donors’ and receptors’ diet be the key to future success?
title_sort fecal microbiota transplantation could stool donors and receptors diet be the key to future success
topic diet
fecal microbiota transplantation
FMT receptors
gut microbiota
stool donors
url https://www.frontiersin.org/articles/10.3389/fgstr.2023.1270899/full
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