Influence of Iron on the Gut Microbiota in Colorectal Cancer
Perturbations of the colonic microbiota can contribute to the initiation and progression of colorectal cancer, leading to an increase in pathogenic bacteria at the expense of protective bacteria. This can contribute to disease through increasing carcinogenic metabolite/toxin production, inducing inf...
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MDPI AG
2020-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/9/2512 |
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| author | Oliver Phipps Hafid O. Al-Hassi Mohammed N. Quraishi Aditi Kumar Matthew J. Brookes |
| author_facet | Oliver Phipps Hafid O. Al-Hassi Mohammed N. Quraishi Aditi Kumar Matthew J. Brookes |
| author_sort | Oliver Phipps |
| collection | DOAJ |
| description | Perturbations of the colonic microbiota can contribute to the initiation and progression of colorectal cancer, leading to an increase in pathogenic bacteria at the expense of protective bacteria. This can contribute to disease through increasing carcinogenic metabolite/toxin production, inducing inflammation, and activating oncogenic signaling. To limit disease progression, external factors that may influence the colonic microbiota need to be considered in patients with colorectal cancer. One major factor that can influence the colonic microbiota is iron. Iron is an essential micronutrient that is required by both prokaryotes and eukaryotes for cellular function. Most pathogenic bacteria have heightened iron acquisition mechanisms and therefore tend to outcompete protective bacteria for free iron. Colorectal cancer patients often present with anemia due to iron deficiency, and thus they require iron therapy. Depending upon the route of administration, iron therapy has the potential to contribute to a procarciongenic microbiota. Orally administered iron is the common treatment for anemia in these patients but can lead to an increased gut iron concentration. This suggests the need to reassess the route of iron therapy in these patients. Currently, this has only been assessed in murine studies, with human trials being necessary to unravel the potential microbial outcomes of iron therapy. |
| first_indexed | 2024-03-10T17:09:30Z |
| format | Article |
| id | doaj.art-f79b015fd3e6470faf3a8b2dd5236758 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T17:09:30Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-f79b015fd3e6470faf3a8b2dd52367582023-11-20T10:43:35ZengMDPI AGNutrients2072-66432020-08-01129251210.3390/nu12092512Influence of Iron on the Gut Microbiota in Colorectal CancerOliver Phipps0Hafid O. Al-Hassi1Mohammed N. Quraishi2Aditi Kumar3Matthew J. Brookes4Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1LY, UKResearch Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1LY, UKInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UKResearch Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1LY, UKResearch Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1LY, UKPerturbations of the colonic microbiota can contribute to the initiation and progression of colorectal cancer, leading to an increase in pathogenic bacteria at the expense of protective bacteria. This can contribute to disease through increasing carcinogenic metabolite/toxin production, inducing inflammation, and activating oncogenic signaling. To limit disease progression, external factors that may influence the colonic microbiota need to be considered in patients with colorectal cancer. One major factor that can influence the colonic microbiota is iron. Iron is an essential micronutrient that is required by both prokaryotes and eukaryotes for cellular function. Most pathogenic bacteria have heightened iron acquisition mechanisms and therefore tend to outcompete protective bacteria for free iron. Colorectal cancer patients often present with anemia due to iron deficiency, and thus they require iron therapy. Depending upon the route of administration, iron therapy has the potential to contribute to a procarciongenic microbiota. Orally administered iron is the common treatment for anemia in these patients but can lead to an increased gut iron concentration. This suggests the need to reassess the route of iron therapy in these patients. Currently, this has only been assessed in murine studies, with human trials being necessary to unravel the potential microbial outcomes of iron therapy.https://www.mdpi.com/2072-6643/12/9/2512ironmicrobiotaprotectivepathogenicbacteriacolorectal cancer |
| spellingShingle | Oliver Phipps Hafid O. Al-Hassi Mohammed N. Quraishi Aditi Kumar Matthew J. Brookes Influence of Iron on the Gut Microbiota in Colorectal Cancer Nutrients iron microbiota protective pathogenic bacteria colorectal cancer |
| title | Influence of Iron on the Gut Microbiota in Colorectal Cancer |
| title_full | Influence of Iron on the Gut Microbiota in Colorectal Cancer |
| title_fullStr | Influence of Iron on the Gut Microbiota in Colorectal Cancer |
| title_full_unstemmed | Influence of Iron on the Gut Microbiota in Colorectal Cancer |
| title_short | Influence of Iron on the Gut Microbiota in Colorectal Cancer |
| title_sort | influence of iron on the gut microbiota in colorectal cancer |
| topic | iron microbiota protective pathogenic bacteria colorectal cancer |
| url | https://www.mdpi.com/2072-6643/12/9/2512 |
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