Vitamin E Supplementation and Circulating Adiponectin Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Current results from clinical trials about vitamin E effects on adiponectin are ambiguous. Therefore, we conducted a meta-analysis of available RCTs to resolve this inconsistency. The systematic search was performed in several databases including SCOPUS, PubMed-Medline, and Google Scholar until Oct...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2017-09-01
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| Series: | International Journal of Nutrition Sciences |
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| Online Access: | http://ijns.sums.ac.ir/index.php/IJNS/article/view/59 |
| _version_ | 1818939665343840256 |
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| author | Mohsen Mohammadi-Sartang Arash Dashtabi Zohreh Mazloom |
| author_facet | Mohsen Mohammadi-Sartang Arash Dashtabi Zohreh Mazloom |
| author_sort | Mohsen Mohammadi-Sartang |
| collection | DOAJ |
| description | Current results from clinical trials about vitamin E effects on
adiponectin are ambiguous. Therefore, we conducted a meta-analysis of available RCTs to resolve this inconsistency. The systematic search was performed in several databases including SCOPUS, PubMed-Medline, and Google Scholar until October 1st, 2017. We used fixedeffects model in combination with mean difference (MD) and 95% confidence intervals (CI) for the analysis of data. Meta-analysis of 6 RCTs (9 treatment arms) showed a significant increase in circulating adiponectin levels (MD: 0.36 ug/ml, 95% CI: 0.16 to 0.56; p<0.001), following vitamin E supplementation. In sub-group analysis, a
significant increasing effect was observed only in trials with ≥400
mg/day dosage (MD: 0.78 ug/ml, 95% CI: 0.31, 1.24, p=0.001) and those trials lasting ≥6 months (MD: 0.58 ug/mL, 95% CI: 0.29, 0.86, p<0.001). In meta-regression, there was association between changes in adiponectin concentrations and duration of supplementation. Our findings showed the significant increase effect of vitamin E supplementation on circulating adiponectin levels, however a significant increasing effect was observed at doses above 400 mg/day and when supplementation lasting over 6 months. |
| first_indexed | 2024-12-20T06:27:21Z |
| format | Article |
| id | doaj.art-f79bc13146874976b40befc9528a39ac |
| institution | Directory Open Access Journal |
| issn | 2538-1873 2538-2829 |
| language | English |
| last_indexed | 2024-12-20T06:27:21Z |
| publishDate | 2017-09-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | International Journal of Nutrition Sciences |
| spelling | doaj.art-f79bc13146874976b40befc9528a39ac2022-12-21T19:50:16ZengShiraz University of Medical SciencesInternational Journal of Nutrition Sciences2538-18732538-28292017-09-0123118125Vitamin E Supplementation and Circulating Adiponectin Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsMohsen Mohammadi-Sartang0Arash Dashtabi1Zohreh Mazloom2Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranNutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranCurrent results from clinical trials about vitamin E effects on adiponectin are ambiguous. Therefore, we conducted a meta-analysis of available RCTs to resolve this inconsistency. The systematic search was performed in several databases including SCOPUS, PubMed-Medline, and Google Scholar until October 1st, 2017. We used fixedeffects model in combination with mean difference (MD) and 95% confidence intervals (CI) for the analysis of data. Meta-analysis of 6 RCTs (9 treatment arms) showed a significant increase in circulating adiponectin levels (MD: 0.36 ug/ml, 95% CI: 0.16 to 0.56; p<0.001), following vitamin E supplementation. In sub-group analysis, a significant increasing effect was observed only in trials with ≥400 mg/day dosage (MD: 0.78 ug/ml, 95% CI: 0.31, 1.24, p=0.001) and those trials lasting ≥6 months (MD: 0.58 ug/mL, 95% CI: 0.29, 0.86, p<0.001). In meta-regression, there was association between changes in adiponectin concentrations and duration of supplementation. Our findings showed the significant increase effect of vitamin E supplementation on circulating adiponectin levels, however a significant increasing effect was observed at doses above 400 mg/day and when supplementation lasting over 6 months.http://ijns.sums.ac.ir/index.php/IJNS/article/view/59Vitamin ETocopherolsAdipokineAdiponectin |
| spellingShingle | Mohsen Mohammadi-Sartang Arash Dashtabi Zohreh Mazloom Vitamin E Supplementation and Circulating Adiponectin Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials International Journal of Nutrition Sciences Vitamin E Tocopherols Adipokine Adiponectin |
| title | Vitamin E Supplementation and Circulating Adiponectin Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_full | Vitamin E Supplementation and Circulating Adiponectin Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_fullStr | Vitamin E Supplementation and Circulating Adiponectin Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_full_unstemmed | Vitamin E Supplementation and Circulating Adiponectin Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_short | Vitamin E Supplementation and Circulating Adiponectin Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_sort | vitamin e supplementation and circulating adiponectin concentrations a systematic review and meta analysis of randomized controlled trials |
| topic | Vitamin E Tocopherols Adipokine Adiponectin |
| url | http://ijns.sums.ac.ir/index.php/IJNS/article/view/59 |
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