Neighborhood poverty during childhood prospectively predicts adolescent functional brain network architecture
Family poverty has been associated with altered brain structure, function, and connectivity in youth. However, few studies have examined how disadvantage within the broader neighborhood may influence functional brain network organization. The present study leveraged a longitudinal community sample o...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929323001214 |
| _version_ | 1797398741374730240 |
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| author | Cleanthis Michael Scott Tillem Chandra S. Sripada S. Alexandra Burt Kelly L. Klump Luke W. Hyde |
| author_facet | Cleanthis Michael Scott Tillem Chandra S. Sripada S. Alexandra Burt Kelly L. Klump Luke W. Hyde |
| author_sort | Cleanthis Michael |
| collection | DOAJ |
| description | Family poverty has been associated with altered brain structure, function, and connectivity in youth. However, few studies have examined how disadvantage within the broader neighborhood may influence functional brain network organization. The present study leveraged a longitudinal community sample of 538 twins living in low-income neighborhoods to evaluate the prospective association between exposure to neighborhood poverty during childhood (6–10 y) with functional network architecture during adolescence (8–19 y). Using resting-state and task-based fMRI, we generated two latent measures that captured intrinsic brain organization across the whole-brain and network levels – network segregation and network segregation-integration balance. While age was positively associated with network segregation and network balance overall across the sample, these associations were moderated by exposure to neighborhood poverty. Specifically, these positive associations were observed only in youth from more, but not less, disadvantaged neighborhoods. Moreover, greater exposure to neighborhood poverty predicted reduced network segregation and network balance in early, but not middle or late, adolescence. These effects were detected both across the whole-brain system as well as specific functional networks, including fronto-parietal, default mode, salience, and subcortical systems. These findings indicate that where children live may exert long-reaching effects on the organization and development of the adolescent brain. |
| first_indexed | 2024-03-09T01:29:52Z |
| format | Article |
| id | doaj.art-f79ca2766be7479ab9370c8eb3187364 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-03-09T01:29:52Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-f79ca2766be7479ab9370c8eb31873642023-12-10T06:14:24ZengElsevierDevelopmental Cognitive Neuroscience1878-92932023-12-0164101316Neighborhood poverty during childhood prospectively predicts adolescent functional brain network architectureCleanthis Michael0Scott Tillem1Chandra S. Sripada2S. Alexandra Burt3Kelly L. Klump4Luke W. Hyde5Department of Psychology, University of Michigan, Ann Arbor, MI, USADepartment of Psychology, University of Michigan, Ann Arbor, MI, USADepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USADepartment of Psychology, Michigan State University, East Lansing, MI, USADepartment of Psychology, Michigan State University, East Lansing, MI, USADepartment of Psychology, University of Michigan, Ann Arbor, MI, USA; Survey Research Center at the Institute for Social Research, University of Michigan, Ann Arbor, MI, USA; Corresponding author at: 2229 East Hall, 530 Church Street, Ann Arbor, MI 48109, USA.Family poverty has been associated with altered brain structure, function, and connectivity in youth. However, few studies have examined how disadvantage within the broader neighborhood may influence functional brain network organization. The present study leveraged a longitudinal community sample of 538 twins living in low-income neighborhoods to evaluate the prospective association between exposure to neighborhood poverty during childhood (6–10 y) with functional network architecture during adolescence (8–19 y). Using resting-state and task-based fMRI, we generated two latent measures that captured intrinsic brain organization across the whole-brain and network levels – network segregation and network segregation-integration balance. While age was positively associated with network segregation and network balance overall across the sample, these associations were moderated by exposure to neighborhood poverty. Specifically, these positive associations were observed only in youth from more, but not less, disadvantaged neighborhoods. Moreover, greater exposure to neighborhood poverty predicted reduced network segregation and network balance in early, but not middle or late, adolescence. These effects were detected both across the whole-brain system as well as specific functional networks, including fronto-parietal, default mode, salience, and subcortical systems. These findings indicate that where children live may exert long-reaching effects on the organization and development of the adolescent brain.http://www.sciencedirect.com/science/article/pii/S1878929323001214Neighborhood povertyNetwork organizationBrain developmentGraph theoryAdolescenceFunctional connectivity |
| spellingShingle | Cleanthis Michael Scott Tillem Chandra S. Sripada S. Alexandra Burt Kelly L. Klump Luke W. Hyde Neighborhood poverty during childhood prospectively predicts adolescent functional brain network architecture Developmental Cognitive Neuroscience Neighborhood poverty Network organization Brain development Graph theory Adolescence Functional connectivity |
| title | Neighborhood poverty during childhood prospectively predicts adolescent functional brain network architecture |
| title_full | Neighborhood poverty during childhood prospectively predicts adolescent functional brain network architecture |
| title_fullStr | Neighborhood poverty during childhood prospectively predicts adolescent functional brain network architecture |
| title_full_unstemmed | Neighborhood poverty during childhood prospectively predicts adolescent functional brain network architecture |
| title_short | Neighborhood poverty during childhood prospectively predicts adolescent functional brain network architecture |
| title_sort | neighborhood poverty during childhood prospectively predicts adolescent functional brain network architecture |
| topic | Neighborhood poverty Network organization Brain development Graph theory Adolescence Functional connectivity |
| url | http://www.sciencedirect.com/science/article/pii/S1878929323001214 |
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