Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema
<h4>Purpose</h4> To assess choroidal vasculature changes in eyes with branch retinal vein occlusion (BRVO) and macular edema (ME) using the choroidal vascularity index (CVI) and evaluate the effectiveness of CVI as a prognostic biomarker. <h4>Methods</h4> 35 patients with mon...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530297/?tool=EBI |
| _version_ | 1819025351129432064 |
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| author | Bo-Een Hwang Mirinae Kim Young-Hoon Park |
| author_facet | Bo-Een Hwang Mirinae Kim Young-Hoon Park |
| author_sort | Bo-Een Hwang |
| collection | DOAJ |
| description | <h4>Purpose</h4> To assess choroidal vasculature changes in eyes with branch retinal vein occlusion (BRVO) and macular edema (ME) using the choroidal vascularity index (CVI) and evaluate the effectiveness of CVI as a prognostic biomarker. <h4>Methods</h4> 35 patients with monocular BRVO and ME were analyzed retrospectively. Luminal and stromal areas in choroids of swept-source optical coherence tomography were calculated using the image binarization technique. The CVI was calculated as the ratio of the luminal to total choroidal area. The CVI of BRVO and ME eyes were compared with that of the unaffected fellow and post anti-vascular endothelial growth factor (VEGF) injected eyes. A regression analysis was performed on the choroidal parameters, logMAR visual acuity (VA) two years post disease onset and central macula thickness (CMT). <h4>Results</h4> The CVI of BRVO and ME eyes was significantly lower than the fellow and post-injected eyes (p<0.05). The regression analysis showed a strong association between two years after logMAR VA and the CVI of fellow eyes (R2 = 0.433, p<0.001). Remarkable correlations were observed in the CVI and subfoveal choroidal thickness of BRVO and ME eyes (R2 = 0.189, 0.155, respectively, p<0.05). The CMT of diseased eyes were also significantly associated with the CVI of unaffected fellow eyes (R2 = 0.113, p<0.05). <h4>Conclusions</h4> The alteration of CVI in BRVO and ME suggests that choroidal vasculature might be affected by extracellular fluid shift and VEGF changes. The fellow eye CVI could be a useful supplementary prognostic biomarker. |
| first_indexed | 2024-12-21T05:09:18Z |
| format | Article |
| id | doaj.art-f79e39ffa3794a18abb32abd8b24ed40 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T05:09:18Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f79e39ffa3794a18abb32abd8b24ed402022-12-21T19:15:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011610Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edemaBo-Een HwangMirinae KimYoung-Hoon Park<h4>Purpose</h4> To assess choroidal vasculature changes in eyes with branch retinal vein occlusion (BRVO) and macular edema (ME) using the choroidal vascularity index (CVI) and evaluate the effectiveness of CVI as a prognostic biomarker. <h4>Methods</h4> 35 patients with monocular BRVO and ME were analyzed retrospectively. Luminal and stromal areas in choroids of swept-source optical coherence tomography were calculated using the image binarization technique. The CVI was calculated as the ratio of the luminal to total choroidal area. The CVI of BRVO and ME eyes were compared with that of the unaffected fellow and post anti-vascular endothelial growth factor (VEGF) injected eyes. A regression analysis was performed on the choroidal parameters, logMAR visual acuity (VA) two years post disease onset and central macula thickness (CMT). <h4>Results</h4> The CVI of BRVO and ME eyes was significantly lower than the fellow and post-injected eyes (p<0.05). The regression analysis showed a strong association between two years after logMAR VA and the CVI of fellow eyes (R2 = 0.433, p<0.001). Remarkable correlations were observed in the CVI and subfoveal choroidal thickness of BRVO and ME eyes (R2 = 0.189, 0.155, respectively, p<0.05). The CMT of diseased eyes were also significantly associated with the CVI of unaffected fellow eyes (R2 = 0.113, p<0.05). <h4>Conclusions</h4> The alteration of CVI in BRVO and ME suggests that choroidal vasculature might be affected by extracellular fluid shift and VEGF changes. The fellow eye CVI could be a useful supplementary prognostic biomarker.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530297/?tool=EBI |
| spellingShingle | Bo-Een Hwang Mirinae Kim Young-Hoon Park Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema PLoS ONE |
| title | Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema |
| title_full | Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema |
| title_fullStr | Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema |
| title_full_unstemmed | Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema |
| title_short | Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema |
| title_sort | role of the choroidal vascularity index in branch retinal vein occlusion brvo with macular edema |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530297/?tool=EBI |
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