Polycystic Ovary Syndrome in Overweight and Normal Weight Women: The Relationships with Inflammatory Markers
Objective:The etiology and pathophysiology of Polycystic Ovary syndrome (PCOS) are not yet clearly explained as the disease has a heterogeneous clinical presentation. Several cytokines produced by the ovary and other tissues contribute to the maintenance of a chronic inflammatory state and metabolic...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2020-06-01
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| Series: | Bagcilar Medical Bulletin |
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| Online Access: |
http://behmedicalbulletin.org/archives/archive-detail/article-preview/polycystic-ovary-syndrome-in-overweight-and-normal/38735
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| author | Tolga Atakul Özgür Deniz Turan Çiğdem Yenisey |
| author_facet | Tolga Atakul Özgür Deniz Turan Çiğdem Yenisey |
| author_sort | Tolga Atakul |
| collection | DOAJ |
| description | Objective:The etiology and pathophysiology of Polycystic Ovary syndrome (PCOS) are not yet clearly explained as the disease has a heterogeneous clinical presentation. Several cytokines produced by the ovary and other tissues contribute to the maintenance of a chronic inflammatory state and metabolic imbalance in PCOS. The present study aims to widen the scientific scope concerning the association between the inflammatory state and PCOS through the measurement and evaluation of several inflammatory markers.Method:Forty-nine medication-naive PCOS patients and 39 healthy controls were enrolled in this case-control study. Blood samples were obtained for the measurement of inflammatory markers.Results:Cyclooxygenase-2 (COX-2), IL-12, IL-18, IL-23, Krüppel-like factor-4 (KLF-4), peroxisome proliferator-activated receptor (PPAR)- gamma, sirtuin (SIRT) and toll-like receptor-2 (TLR-2) were found to be significantly higher in the PCOS group compared to the healthy controls. There were no significant differences regarding these inflammatory markers when overweight and normal weight PCOS women were compared (p>0.05). Receiver operating characteristic curve analysis revealed that the following cut-off values had satisfactory sensitivity and specificity for the diagnosis of PCOS: 5.9 ng/mL for COX-2, 22.3 pg/mL for IL-12, 32 pg/mL for IL-18, 57 pg/mL for IL-23, 203 pg/mL for KLF- 4, 2.54 ng/mL for PPAR-gamma, 2.9 ng/mL for SIRT, and 2 ng/mL for TLR-2.Conclusion:Our findings demonstrate that these inflammatory markers might be used to identify patients with PCOS with high sensitivity and specificity. Our results support the consideration that the low-grade inflammation observed in women with PCOS is likely intrinsic to the pathophysiology of the disease. |
| first_indexed | 2024-04-10T13:05:33Z |
| format | Article |
| id | doaj.art-f79e467398cd43b3a890bbaa07b77d13 |
| institution | Directory Open Access Journal |
| issn | 2547-9431 |
| language | English |
| last_indexed | 2024-04-10T13:05:33Z |
| publishDate | 2020-06-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Bagcilar Medical Bulletin |
| spelling | doaj.art-f79e467398cd43b3a890bbaa07b77d132023-02-15T16:12:58ZengGalenos YayineviBagcilar Medical Bulletin2547-94312020-06-0152455110.4274/BMB.galenos.2020.03.0713049054Polycystic Ovary Syndrome in Overweight and Normal Weight Women: The Relationships with Inflammatory MarkersTolga Atakul0Özgür Deniz Turan1Çiğdem Yenisey2 Adnan Menderes University Faculty of Medicine, Department of Obstetrics and Gynecology, Aydın, Turkey Adnan Menderes University Faculty of Medicine, Department of Obstetrics and Gynecology, Aydın, Turkey Adnan Menderes University Faculty of Medicine, Department of Medical Biochemistry, Aydın, Turkey Objective:The etiology and pathophysiology of Polycystic Ovary syndrome (PCOS) are not yet clearly explained as the disease has a heterogeneous clinical presentation. Several cytokines produced by the ovary and other tissues contribute to the maintenance of a chronic inflammatory state and metabolic imbalance in PCOS. The present study aims to widen the scientific scope concerning the association between the inflammatory state and PCOS through the measurement and evaluation of several inflammatory markers.Method:Forty-nine medication-naive PCOS patients and 39 healthy controls were enrolled in this case-control study. Blood samples were obtained for the measurement of inflammatory markers.Results:Cyclooxygenase-2 (COX-2), IL-12, IL-18, IL-23, Krüppel-like factor-4 (KLF-4), peroxisome proliferator-activated receptor (PPAR)- gamma, sirtuin (SIRT) and toll-like receptor-2 (TLR-2) were found to be significantly higher in the PCOS group compared to the healthy controls. There were no significant differences regarding these inflammatory markers when overweight and normal weight PCOS women were compared (p>0.05). Receiver operating characteristic curve analysis revealed that the following cut-off values had satisfactory sensitivity and specificity for the diagnosis of PCOS: 5.9 ng/mL for COX-2, 22.3 pg/mL for IL-12, 32 pg/mL for IL-18, 57 pg/mL for IL-23, 203 pg/mL for KLF- 4, 2.54 ng/mL for PPAR-gamma, 2.9 ng/mL for SIRT, and 2 ng/mL for TLR-2.Conclusion:Our findings demonstrate that these inflammatory markers might be used to identify patients with PCOS with high sensitivity and specificity. Our results support the consideration that the low-grade inflammation observed in women with PCOS is likely intrinsic to the pathophysiology of the disease. http://behmedicalbulletin.org/archives/archive-detail/article-preview/polycystic-ovary-syndrome-in-overweight-and-normal/38735 cyclooxygenase-2interleukinskrüppel-like factor-4lowgrade inflammationpolycystic ovary syndrome |
| spellingShingle | Tolga Atakul Özgür Deniz Turan Çiğdem Yenisey Polycystic Ovary Syndrome in Overweight and Normal Weight Women: The Relationships with Inflammatory Markers Bagcilar Medical Bulletin cyclooxygenase-2 interleukins krüppel-like factor-4 lowgrade inflammation polycystic ovary syndrome |
| title | Polycystic Ovary Syndrome in Overweight and Normal Weight Women: The Relationships with Inflammatory Markers |
| title_full | Polycystic Ovary Syndrome in Overweight and Normal Weight Women: The Relationships with Inflammatory Markers |
| title_fullStr | Polycystic Ovary Syndrome in Overweight and Normal Weight Women: The Relationships with Inflammatory Markers |
| title_full_unstemmed | Polycystic Ovary Syndrome in Overweight and Normal Weight Women: The Relationships with Inflammatory Markers |
| title_short | Polycystic Ovary Syndrome in Overweight and Normal Weight Women: The Relationships with Inflammatory Markers |
| title_sort | polycystic ovary syndrome in overweight and normal weight women the relationships with inflammatory markers |
| topic | cyclooxygenase-2 interleukins krüppel-like factor-4 lowgrade inflammation polycystic ovary syndrome |
| url |
http://behmedicalbulletin.org/archives/archive-detail/article-preview/polycystic-ovary-syndrome-in-overweight-and-normal/38735
|
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