Genetic risk scores and dementia risk across different ethnic groups in UK Biobank
<h4>Background</h4> Genetic Risk Scores (GRS) for predicting dementia risk have mostly been used in people of European ancestry with limited testing in other ancestry groups. <h4>Methods</h4> We conducted a logistic regression with all-cause dementia as the outcome and z-stan...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728885/?tool=EBI |
| _version_ | 1811294659689840640 |
|---|---|
| author | Naaheed Mukadam Olga Giannakopoulou Nick Bass Karoline Kuchenbaecker Andrew McQuillin |
| author_facet | Naaheed Mukadam Olga Giannakopoulou Nick Bass Karoline Kuchenbaecker Andrew McQuillin |
| author_sort | Naaheed Mukadam |
| collection | DOAJ |
| description | <h4>Background</h4> Genetic Risk Scores (GRS) for predicting dementia risk have mostly been used in people of European ancestry with limited testing in other ancestry groups. <h4>Methods</h4> We conducted a logistic regression with all-cause dementia as the outcome and z-standardised GRS as the exposure across diverse ethnic groups. <h4>Findings</h4> There was variation in frequency of APOE alleles across ethnic groups. Per standard deviation (SD) increase in z-GRS including APOE, the odds ratio (OR) for dementia was 1.73 (95%CI 1.69–1.77). Z-GRS excluding APOE also increased dementia risk (OR 1.21 per SD increase, 95% CI 1.18–1.24) and there was no evidence that ethnicity modified this association. Prediction of secondary outcomes was less robust in those not of European ancestry when APOE was excluded from the GRS. <h4>Interpretation</h4> z-GRS derived from studies in people of European ancestry can be used to quantify genetic risk in people from more diverse ancestry groups. Urgent work is needed to include people from diverse ancestries in future genetic risk studies to make this field more inclusive. |
| first_indexed | 2024-04-13T05:20:44Z |
| format | Article |
| id | doaj.art-f79f2f6f641248e390678004120f10f5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T05:20:44Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f79f2f6f641248e390678004120f10f52022-12-22T03:00:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011712Genetic risk scores and dementia risk across different ethnic groups in UK BiobankNaaheed MukadamOlga GiannakopoulouNick BassKaroline KuchenbaeckerAndrew McQuillin<h4>Background</h4> Genetic Risk Scores (GRS) for predicting dementia risk have mostly been used in people of European ancestry with limited testing in other ancestry groups. <h4>Methods</h4> We conducted a logistic regression with all-cause dementia as the outcome and z-standardised GRS as the exposure across diverse ethnic groups. <h4>Findings</h4> There was variation in frequency of APOE alleles across ethnic groups. Per standard deviation (SD) increase in z-GRS including APOE, the odds ratio (OR) for dementia was 1.73 (95%CI 1.69–1.77). Z-GRS excluding APOE also increased dementia risk (OR 1.21 per SD increase, 95% CI 1.18–1.24) and there was no evidence that ethnicity modified this association. Prediction of secondary outcomes was less robust in those not of European ancestry when APOE was excluded from the GRS. <h4>Interpretation</h4> z-GRS derived from studies in people of European ancestry can be used to quantify genetic risk in people from more diverse ancestry groups. Urgent work is needed to include people from diverse ancestries in future genetic risk studies to make this field more inclusive.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728885/?tool=EBI |
| spellingShingle | Naaheed Mukadam Olga Giannakopoulou Nick Bass Karoline Kuchenbaecker Andrew McQuillin Genetic risk scores and dementia risk across different ethnic groups in UK Biobank PLoS ONE |
| title | Genetic risk scores and dementia risk across different ethnic groups in UK Biobank |
| title_full | Genetic risk scores and dementia risk across different ethnic groups in UK Biobank |
| title_fullStr | Genetic risk scores and dementia risk across different ethnic groups in UK Biobank |
| title_full_unstemmed | Genetic risk scores and dementia risk across different ethnic groups in UK Biobank |
| title_short | Genetic risk scores and dementia risk across different ethnic groups in UK Biobank |
| title_sort | genetic risk scores and dementia risk across different ethnic groups in uk biobank |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728885/?tool=EBI |
| work_keys_str_mv | AT naaheedmukadam geneticriskscoresanddementiariskacrossdifferentethnicgroupsinukbiobank AT olgagiannakopoulou geneticriskscoresanddementiariskacrossdifferentethnicgroupsinukbiobank AT nickbass geneticriskscoresanddementiariskacrossdifferentethnicgroupsinukbiobank AT karolinekuchenbaecker geneticriskscoresanddementiariskacrossdifferentethnicgroupsinukbiobank AT andrewmcquillin geneticriskscoresanddementiariskacrossdifferentethnicgroupsinukbiobank |