STUDY OF THE ASSOCIATION OF POLYMORPHOUS MARKERS FOR IL1 FAMILY GENES (IL1B AND ILRA) WITH CLINICAL VARIANTS OF PYELONEPHRITIS
Aim: to study the distribution of alleles and genotypes of polymorphic markers for immunoregulatory cytokines in the development of chronic pyelonephritis and its clinical variants. Patients and Methods: in this study we analyzed a sample of 99 patients with chronic pyelonephritis. The average age o...
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| Format: | Article |
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"Paediatrician" Publishers LLC
2014-01-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/227 |
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| author | E. I. Kondrat'eva A. A. Terent'eva N. V. Tarasenko E. V. Loshkova A. I. Tlif |
| author_facet | E. I. Kondrat'eva A. A. Terent'eva N. V. Tarasenko E. V. Loshkova A. I. Tlif |
| author_sort | E. I. Kondrat'eva |
| collection | DOAJ |
| description | Aim: to study the distribution of alleles and genotypes of polymorphic markers for immunoregulatory cytokines in the development of chronic pyelonephritis and its clinical variants. Patients and Methods: in this study we analyzed a sample of 99 patients with chronic pyelonephritis. The average age of the patients was 8,01±3,26 (3,00–15,00) years. The study of gene polymorphisms was performed using PDRF analysis. For PCR were used primers structures and genotyping conditions described in the literature. Results: the analysis of associations of 2 loci in the genes of cytokines with different complex phenotypes of chronic pyelonephritis demonstrated that A2 allele and genotype A2A2 of IL1RN*VNTR polymorphism is associated with chronic pyelonephritis, vesicoureteral reflux, secondary pyelonephritis, renal dysfunction, infection with Escherichia coli and Klebsiella. Genotype A2A2 of gene IL1RN*VNTR and allele A2 of gene IL1RN*VNTR are associated with impaired renal function OR =3,07 (p =0,001). The highest risk of chronic renal failure development is associated with A1A2 genotype (OR =22,94; p=0,001). Conclusions: the discovered associations require further confirmation on larger samples and various ethnicities. |
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| format | Article |
| id | doaj.art-f7a07d75d1964fcd9af510af8ec84bbb |
| institution | Directory Open Access Journal |
| issn | 1682-5527 1682-5535 |
| language | English |
| last_indexed | 2024-03-12T03:42:10Z |
| publishDate | 2014-01-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj.art-f7a07d75d1964fcd9af510af8ec84bbb2023-09-03T13:02:28Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352014-01-01131606410.15690/vsp.v13i1.912227STUDY OF THE ASSOCIATION OF POLYMORPHOUS MARKERS FOR IL1 FAMILY GENES (IL1B AND ILRA) WITH CLINICAL VARIANTS OF PYELONEPHRITISE. I. Kondrat'eva0A. A. Terent'eva1N. V. Tarasenko2E. V. Loshkova3A. I. Tlif4Кубанский государственный медицинский университет, Краснодар Медико-генетический научный центр, МоскваСибирский государственный медицинский университет, ТомскНИИ медицинской генетики СО, ТомскСибирский государственный медицинский университет, ТомскКубанский государственный медицинский университет, КраснодарAim: to study the distribution of alleles and genotypes of polymorphic markers for immunoregulatory cytokines in the development of chronic pyelonephritis and its clinical variants. Patients and Methods: in this study we analyzed a sample of 99 patients with chronic pyelonephritis. The average age of the patients was 8,01±3,26 (3,00–15,00) years. The study of gene polymorphisms was performed using PDRF analysis. For PCR were used primers structures and genotyping conditions described in the literature. Results: the analysis of associations of 2 loci in the genes of cytokines with different complex phenotypes of chronic pyelonephritis demonstrated that A2 allele and genotype A2A2 of IL1RN*VNTR polymorphism is associated with chronic pyelonephritis, vesicoureteral reflux, secondary pyelonephritis, renal dysfunction, infection with Escherichia coli and Klebsiella. Genotype A2A2 of gene IL1RN*VNTR and allele A2 of gene IL1RN*VNTR are associated with impaired renal function OR =3,07 (p =0,001). The highest risk of chronic renal failure development is associated with A1A2 genotype (OR =22,94; p=0,001). Conclusions: the discovered associations require further confirmation on larger samples and various ethnicities.https://vsp.spr-journal.ru/jour/article/view/227воспалениехронический пиелонефритгены семейства il1 |
| spellingShingle | E. I. Kondrat'eva A. A. Terent'eva N. V. Tarasenko E. V. Loshkova A. I. Tlif STUDY OF THE ASSOCIATION OF POLYMORPHOUS MARKERS FOR IL1 FAMILY GENES (IL1B AND ILRA) WITH CLINICAL VARIANTS OF PYELONEPHRITIS Вопросы современной педиатрии воспаление хронический пиелонефрит гены семейства il1 |
| title | STUDY OF THE ASSOCIATION OF POLYMORPHOUS MARKERS FOR IL1 FAMILY GENES (IL1B AND ILRA) WITH CLINICAL VARIANTS OF PYELONEPHRITIS |
| title_full | STUDY OF THE ASSOCIATION OF POLYMORPHOUS MARKERS FOR IL1 FAMILY GENES (IL1B AND ILRA) WITH CLINICAL VARIANTS OF PYELONEPHRITIS |
| title_fullStr | STUDY OF THE ASSOCIATION OF POLYMORPHOUS MARKERS FOR IL1 FAMILY GENES (IL1B AND ILRA) WITH CLINICAL VARIANTS OF PYELONEPHRITIS |
| title_full_unstemmed | STUDY OF THE ASSOCIATION OF POLYMORPHOUS MARKERS FOR IL1 FAMILY GENES (IL1B AND ILRA) WITH CLINICAL VARIANTS OF PYELONEPHRITIS |
| title_short | STUDY OF THE ASSOCIATION OF POLYMORPHOUS MARKERS FOR IL1 FAMILY GENES (IL1B AND ILRA) WITH CLINICAL VARIANTS OF PYELONEPHRITIS |
| title_sort | study of the association of polymorphous markers for il1 family genes il1b and ilra with clinical variants of pyelonephritis |
| topic | воспаление хронический пиелонефрит гены семейства il1 |
| url | https://vsp.spr-journal.ru/jour/article/view/227 |
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