<em>Streptomyces</em> Isolates from the Soil of an Ancient Irish Cure Site, Capable of Inhibiting Multi-Resistant Bacteria and Yeasts
Traditional Irish medicines are often intertwined with ritual and spirituality, making it difficult to substantiate the validity of their claims. In this manuscript, we use molecular and microscopic techniques to investigate some microorganisms that might be responsible for the reputed healing prope...
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2021-05-01
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| author | Gerry A. Quinn Alyaa M. Abdelhameed Aiya M. Banat Nada K. Alharbi Laura M. Baker Helena Carlo Castro Paul J. Dyson Paul D. Facey Diego Cobice Luciana Terra Simms A. Adu Martin T. Swain Ibrahim M. Banat |
| author_facet | Gerry A. Quinn Alyaa M. Abdelhameed Aiya M. Banat Nada K. Alharbi Laura M. Baker Helena Carlo Castro Paul J. Dyson Paul D. Facey Diego Cobice Luciana Terra Simms A. Adu Martin T. Swain Ibrahim M. Banat |
| author_sort | Gerry A. Quinn |
| collection | DOAJ |
| description | Traditional Irish medicines are often intertwined with ritual and spirituality, making it difficult to substantiate the validity of their claims. In this manuscript, we use molecular and microscopic techniques to investigate some microorganisms that might be responsible for the reputed healing properties of an ancient Irish soil cure known as the Blessed clay from a site in Boho in the West Fermanagh Scarplands. We previously reported the isolation of an antibiotic producing bacteria from this soil. In this report, we characterize the antibiotic activity of a further six isolates of <i>Streptomyces</i> from this source. Two of these isolates inhibit the growth of multi-resistant <i>Staphylococcus aureus</i> (MRSA) and <i>Pseudomonas aeruginosa</i>, two inhibit the growth of the yeast <i>Starmerella bombicola</i>, and two have as yet undetermined activity. Genetic analysis of these <i>Streptomyces</i> reveals the potential to synthesize varieties of antibiotics similar to cypemycin, griseochelin, macrolactams, and candicidin. From these observations, we suggest that part of the medicinal reputation of the Blessed clay may lie in the diversity of antimicrobial producing <i>Streptomyces</i> isolated from this soil. These findings highlight the potential for antibiotic discovery in this area. |
| first_indexed | 2024-03-10T11:00:01Z |
| format | Article |
| id | doaj.art-f7a106138cf5441581578b41f64157f5 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T11:00:01Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-f7a106138cf5441581578b41f64157f52023-11-21T21:36:42ZengMDPI AGApplied Sciences2076-34172021-05-011111492310.3390/app11114923<em>Streptomyces</em> Isolates from the Soil of an Ancient Irish Cure Site, Capable of Inhibiting Multi-Resistant Bacteria and YeastsGerry A. Quinn0Alyaa M. Abdelhameed1Aiya M. Banat2Nada K. Alharbi3Laura M. Baker4Helena Carlo Castro5Paul J. Dyson6Paul D. Facey7Diego Cobice8Luciana Terra9Simms A. Adu10Martin T. Swain11Ibrahim M. Banat12Centre for Molecular Biosciences, Ulster University, Coleraine BT52 1SA, N. Ireland, UKDepartment of Biotechnology, College of Science, University of Diyala, Baqubah 32001, IraqDepartment of Orthopaedics, Altnagelvin Hospital, Londonderry BT47 6SB, N. Ireland, UKDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi ArabiaInstitute of Life Sciences, Medical School, Swansea University, Singleton Park, Swansea SA2 8PP, Wales, UKInstituto de Biologia, Rua Outeiro de São João Batista, s/nº Campus do Valonguinho, Universidade Federal Fluminense, Niterói 24210-130, BrazilInstitute of Life Sciences, Medical School, Swansea University, Singleton Park, Swansea SA2 8PP, Wales, UKInstitute of Life Sciences, Medical School, Swansea University, Singleton Park, Swansea SA2 8PP, Wales, UKCentre for Molecular Biosciences, Ulster University, Coleraine BT52 1SA, N. Ireland, UKInstitute of Life Sciences, Medical School, Swansea University, Singleton Park, Swansea SA2 8PP, Wales, UKCentre for Molecular Biosciences, Ulster University, Coleraine BT52 1SA, N. Ireland, UKIBERS, Aberystwyth University, Penglais, Aberystwyth, Ceredigion SY23 3EE, Wales, UKCentre for Molecular Biosciences, Ulster University, Coleraine BT52 1SA, N. Ireland, UKTraditional Irish medicines are often intertwined with ritual and spirituality, making it difficult to substantiate the validity of their claims. In this manuscript, we use molecular and microscopic techniques to investigate some microorganisms that might be responsible for the reputed healing properties of an ancient Irish soil cure known as the Blessed clay from a site in Boho in the West Fermanagh Scarplands. We previously reported the isolation of an antibiotic producing bacteria from this soil. In this report, we characterize the antibiotic activity of a further six isolates of <i>Streptomyces</i> from this source. Two of these isolates inhibit the growth of multi-resistant <i>Staphylococcus aureus</i> (MRSA) and <i>Pseudomonas aeruginosa</i>, two inhibit the growth of the yeast <i>Starmerella bombicola</i>, and two have as yet undetermined activity. Genetic analysis of these <i>Streptomyces</i> reveals the potential to synthesize varieties of antibiotics similar to cypemycin, griseochelin, macrolactams, and candicidin. From these observations, we suggest that part of the medicinal reputation of the Blessed clay may lie in the diversity of antimicrobial producing <i>Streptomyces</i> isolated from this soil. These findings highlight the potential for antibiotic discovery in this area.https://www.mdpi.com/2076-3417/11/11/4923ethnopharmacologysoilantimicrobial<i>streptomyces</i>antibioticsMRSA |
| spellingShingle | Gerry A. Quinn Alyaa M. Abdelhameed Aiya M. Banat Nada K. Alharbi Laura M. Baker Helena Carlo Castro Paul J. Dyson Paul D. Facey Diego Cobice Luciana Terra Simms A. Adu Martin T. Swain Ibrahim M. Banat <em>Streptomyces</em> Isolates from the Soil of an Ancient Irish Cure Site, Capable of Inhibiting Multi-Resistant Bacteria and Yeasts Applied Sciences ethnopharmacology soil antimicrobial <i>streptomyces</i> antibiotics MRSA |
| title | <em>Streptomyces</em> Isolates from the Soil of an Ancient Irish Cure Site, Capable of Inhibiting Multi-Resistant Bacteria and Yeasts |
| title_full | <em>Streptomyces</em> Isolates from the Soil of an Ancient Irish Cure Site, Capable of Inhibiting Multi-Resistant Bacteria and Yeasts |
| title_fullStr | <em>Streptomyces</em> Isolates from the Soil of an Ancient Irish Cure Site, Capable of Inhibiting Multi-Resistant Bacteria and Yeasts |
| title_full_unstemmed | <em>Streptomyces</em> Isolates from the Soil of an Ancient Irish Cure Site, Capable of Inhibiting Multi-Resistant Bacteria and Yeasts |
| title_short | <em>Streptomyces</em> Isolates from the Soil of an Ancient Irish Cure Site, Capable of Inhibiting Multi-Resistant Bacteria and Yeasts |
| title_sort | em streptomyces em isolates from the soil of an ancient irish cure site capable of inhibiting multi resistant bacteria and yeasts |
| topic | ethnopharmacology soil antimicrobial <i>streptomyces</i> antibiotics MRSA |
| url | https://www.mdpi.com/2076-3417/11/11/4923 |
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