Efficacy of statins on renal function in patients with chronic kidney disease: a systematic review and meta-analysis
Background Studies have shown that the use of statins could significantly improve lipid profiles; however, it remains controversial whether the use of statins could improve renal function in patients with chronic kidney disease (CKD). Therefore, we conducted a meta-analysis of randomized controlled...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Renal Failure |
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| Online Access: | http://dx.doi.org/10.1080/0886022X.2021.1915799 |
| _version_ | 1798031778966929408 |
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| author | Lin Zhao Shu Li Ying Gao |
| author_facet | Lin Zhao Shu Li Ying Gao |
| author_sort | Lin Zhao |
| collection | DOAJ |
| description | Background Studies have shown that the use of statins could significantly improve lipid profiles; however, it remains controversial whether the use of statins could improve renal function in patients with chronic kidney disease (CKD). Therefore, we conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of statins on renal function in patients with CKD. Methods We systematically searched PubMed, EMBASE, and the Cochrane Library databases for eligible RCTs from inception to October 2020. Pooled effect estimates were assigned as weighted mean differences (WMDs) with 95% confidence intervals (CIs) using the random-effects model. Results We selected 33 RCTs that recruited 37,391 patients with CKD patients. The summary results suggested that statin use significantly reduced urinary albumin (WMD: −2.04; 95%CI: −3.53 to −0.56; p = .007) and protein (WMD: −0.58; 95%CI: −0.95 to −0.21; p = .002) excretions and increased creatinine clearance (WMD: 0.86; 95%CI: 0.32–1.41; p = .002). However, there were no significant differences between statin and control groups in terms of changes in estimated glomerular filtration rate (WMD: 0.38; 95%CI: −0.04 to 0.79; p = .075), and serum creatinine levels (WMD: −0.07; 95%CI: −0.25, 0.12; p = .475). Conclusions We found that statin use in patients with CKD may slow CKD progression by lowering urinary albumin and protein excretions or increasing creatinine clearance. Further large-scale RCTs should be conducted to evaluate the long-term effects of statins on renal outcomes. Abbreviations: CKD: chronic kidney disease; RCT: randomized controlled trials; WMD: weighted mean differences; CI: confidence intervals; ACEI: angiotensin-converting enzyme inhibitors; eGFR: estimated glomerular filtration rate |
| first_indexed | 2024-04-11T20:01:57Z |
| format | Article |
| id | doaj.art-f7a5edb764f340f5ae43ba72e10cd4ea |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-04-11T20:01:57Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-f7a5edb764f340f5ae43ba72e10cd4ea2022-12-22T04:05:32ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492021-01-0143171872810.1080/0886022X.2021.19157991915799Efficacy of statins on renal function in patients with chronic kidney disease: a systematic review and meta-analysisLin Zhao0Shu Li1Ying Gao2International Medical School, Tianjin Medical UniversitySchool of Public Health, Tianjin Medical UniversityHealth Management Center, Tianjin Medical University General HospitalBackground Studies have shown that the use of statins could significantly improve lipid profiles; however, it remains controversial whether the use of statins could improve renal function in patients with chronic kidney disease (CKD). Therefore, we conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of statins on renal function in patients with CKD. Methods We systematically searched PubMed, EMBASE, and the Cochrane Library databases for eligible RCTs from inception to October 2020. Pooled effect estimates were assigned as weighted mean differences (WMDs) with 95% confidence intervals (CIs) using the random-effects model. Results We selected 33 RCTs that recruited 37,391 patients with CKD patients. The summary results suggested that statin use significantly reduced urinary albumin (WMD: −2.04; 95%CI: −3.53 to −0.56; p = .007) and protein (WMD: −0.58; 95%CI: −0.95 to −0.21; p = .002) excretions and increased creatinine clearance (WMD: 0.86; 95%CI: 0.32–1.41; p = .002). However, there were no significant differences between statin and control groups in terms of changes in estimated glomerular filtration rate (WMD: 0.38; 95%CI: −0.04 to 0.79; p = .075), and serum creatinine levels (WMD: −0.07; 95%CI: −0.25, 0.12; p = .475). Conclusions We found that statin use in patients with CKD may slow CKD progression by lowering urinary albumin and protein excretions or increasing creatinine clearance. Further large-scale RCTs should be conducted to evaluate the long-term effects of statins on renal outcomes. Abbreviations: CKD: chronic kidney disease; RCT: randomized controlled trials; WMD: weighted mean differences; CI: confidence intervals; ACEI: angiotensin-converting enzyme inhibitors; eGFR: estimated glomerular filtration ratehttp://dx.doi.org/10.1080/0886022X.2021.1915799statinschronic kidney diseaserenal functionmeta-analysis |
| spellingShingle | Lin Zhao Shu Li Ying Gao Efficacy of statins on renal function in patients with chronic kidney disease: a systematic review and meta-analysis Renal Failure statins chronic kidney disease renal function meta-analysis |
| title | Efficacy of statins on renal function in patients with chronic kidney disease: a systematic review and meta-analysis |
| title_full | Efficacy of statins on renal function in patients with chronic kidney disease: a systematic review and meta-analysis |
| title_fullStr | Efficacy of statins on renal function in patients with chronic kidney disease: a systematic review and meta-analysis |
| title_full_unstemmed | Efficacy of statins on renal function in patients with chronic kidney disease: a systematic review and meta-analysis |
| title_short | Efficacy of statins on renal function in patients with chronic kidney disease: a systematic review and meta-analysis |
| title_sort | efficacy of statins on renal function in patients with chronic kidney disease a systematic review and meta analysis |
| topic | statins chronic kidney disease renal function meta-analysis |
| url | http://dx.doi.org/10.1080/0886022X.2021.1915799 |
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