Methods for Assessment of the Glomerular Filtration Rate in Laboratory Animals
Background: The glomerular filtration rate (GFR), as the benchmark of renal function, has been widely used in clinical practice and basic medical research. Currently, most researchers still rely on endogenous markers, such as plasma creatinine, blood urea nitrogen, and cystatin C, to evaluate renal...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2022-06-01
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| Series: | Kidney Diseases |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/525049 |
| _version_ | 1818518590162206720 |
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| author | Xiangyang Gu Baoxue Yang |
| author_facet | Xiangyang Gu Baoxue Yang |
| author_sort | Xiangyang Gu |
| collection | DOAJ |
| description | Background: The glomerular filtration rate (GFR), as the benchmark of renal function, has been widely used in clinical practice and basic medical research. Currently, most researchers still rely on endogenous markers, such as plasma creatinine, blood urea nitrogen, and cystatin C, to evaluate renal function in laboratory animals. While inexpensive and simple to use, methods based on endogenous markers are often inaccurate and susceptible to several internal physiological factors. Thus, it is necessary to establish a method to precisely assess the GFR, especially when detecting early changes in GFR during acute kidney injury, and hyperfiltration usually caused by pregnancy or diabetic nephropathy. In addition, laboratory animals have higher tolerance for invasive procedures than humans, allowing novel technologies to be applied on them for GFR monitoring. In recent years, significant progress has been made in developing new methods to assess GFR in animals. However, no publication has reviewed these techniques. Summary: This article summarized the majority of methods used to assess the GFR in animals in recent decades and discussed their working principles, workflows, advantages, and limitations, providing a wealth of reference and information for researchers interested in studying the kidney function in animals and developing techniques to monitor the GFR. |
| first_indexed | 2024-12-11T01:12:10Z |
| format | Article |
| id | doaj.art-f7a65bad632c4bcab994463bdad37e5a |
| institution | Directory Open Access Journal |
| issn | 2296-9381 2296-9357 |
| language | English |
| last_indexed | 2024-12-11T01:12:10Z |
| publishDate | 2022-06-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney Diseases |
| spelling | doaj.art-f7a65bad632c4bcab994463bdad37e5a2022-12-22T01:26:00ZengKarger PublishersKidney Diseases2296-93812296-93572022-06-0111110.1159/000525049525049Methods for Assessment of the Glomerular Filtration Rate in Laboratory AnimalsXiangyang Gu0https://orcid.org/0000-0003-4602-6524Baoxue Yang1Huadong Medicine Co. Ltd., Hangzhou, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, ChinaBackground: The glomerular filtration rate (GFR), as the benchmark of renal function, has been widely used in clinical practice and basic medical research. Currently, most researchers still rely on endogenous markers, such as plasma creatinine, blood urea nitrogen, and cystatin C, to evaluate renal function in laboratory animals. While inexpensive and simple to use, methods based on endogenous markers are often inaccurate and susceptible to several internal physiological factors. Thus, it is necessary to establish a method to precisely assess the GFR, especially when detecting early changes in GFR during acute kidney injury, and hyperfiltration usually caused by pregnancy or diabetic nephropathy. In addition, laboratory animals have higher tolerance for invasive procedures than humans, allowing novel technologies to be applied on them for GFR monitoring. In recent years, significant progress has been made in developing new methods to assess GFR in animals. However, no publication has reviewed these techniques. Summary: This article summarized the majority of methods used to assess the GFR in animals in recent decades and discussed their working principles, workflows, advantages, and limitations, providing a wealth of reference and information for researchers interested in studying the kidney function in animals and developing techniques to monitor the GFR.https://www.karger.com/Article/FullText/525049glomerular filtration ratelaboratory animalassessment method |
| spellingShingle | Xiangyang Gu Baoxue Yang Methods for Assessment of the Glomerular Filtration Rate in Laboratory Animals Kidney Diseases glomerular filtration rate laboratory animal assessment method |
| title | Methods for Assessment of the Glomerular Filtration Rate in Laboratory Animals |
| title_full | Methods for Assessment of the Glomerular Filtration Rate in Laboratory Animals |
| title_fullStr | Methods for Assessment of the Glomerular Filtration Rate in Laboratory Animals |
| title_full_unstemmed | Methods for Assessment of the Glomerular Filtration Rate in Laboratory Animals |
| title_short | Methods for Assessment of the Glomerular Filtration Rate in Laboratory Animals |
| title_sort | methods for assessment of the glomerular filtration rate in laboratory animals |
| topic | glomerular filtration rate laboratory animal assessment method |
| url | https://www.karger.com/Article/FullText/525049 |
| work_keys_str_mv | AT xiangyanggu methodsforassessmentoftheglomerularfiltrationrateinlaboratoryanimals AT baoxueyang methodsforassessmentoftheglomerularfiltrationrateinlaboratoryanimals |