Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes
Both insulin and IGF-1 signaling have been implicated in arterial intimal hyperplasia. Here the authors dissect the relative contributions of insulin and IGF-1 receptors, showing that homodimers of insulin receptors, but not IGF-1 receptor, induce proliferation of vascular smooth muscle cells.
Bibliographic Details
| Main Authors: |
Qian Li,
Jialin Fu,
Yu Xia,
Weier Qi,
Atsushi Ishikado,
Kyoungmin Park,
Hisashi Yokomizo,
Qian Huang,
Weikang Cai,
Christian Rask-Madsen,
C. Ronald Kahn,
George L. King |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2019-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-12368-2
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