Recent trends and innovations in biosensors development for biomarkers towards monitoring traumatic brain injury
Traumatic brain injury (TBI) is a serious health concern and a leading cause of death in all age groups, especially adults. Although the processes of prevention, lifestyle modification, accident safety, and therapeutic management of TBI are constantly evolving, the development of accurate and trustw...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Biosensors and Bioelectronics: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590137022001406 |
| _version_ | 1797980855643144192 |
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| author | Mehrasa Rahimi Borumand Fatemeh Babaloii Seyedeh Azin Mirmotahari Armin Salek Maghsoudi Raheleh Torabi Mojtaba Mojtahedzadeh Parviz Norouzi Mazda Rad-Malekshahi Hamid Akbari Javar Shokoufeh Hassani |
| author_facet | Mehrasa Rahimi Borumand Fatemeh Babaloii Seyedeh Azin Mirmotahari Armin Salek Maghsoudi Raheleh Torabi Mojtaba Mojtahedzadeh Parviz Norouzi Mazda Rad-Malekshahi Hamid Akbari Javar Shokoufeh Hassani |
| author_sort | Mehrasa Rahimi Borumand |
| collection | DOAJ |
| description | Traumatic brain injury (TBI) is a serious health concern and a leading cause of death in all age groups, especially adults. Although the processes of prevention, lifestyle modification, accident safety, and therapeutic management of TBI are constantly evolving, the development of accurate and trustworthy procedures for diagnosing brain damage, such as detecting specific biomarkers is still in its infancy. Early detection of TBI biomarkers, especially blood biomarkers, can improve treatment approaches and significantly reduce diagnostic costs. Different routine analytical methods, including ELISA and PCR techniques, have been used to detect TBI biomarkers. These procedures are generally complex, expensive, time-consuming, and require trained personnel. In contrast, biosensing techniques have been developed precisely through addressing the aforementioned weaknesses along with offering an accessible, affordable, rapid, highly sensitive, and specific approach. This comprehensive review presents the six main TBI biomarkers (S100β, NSE, GFAP, UCHL-1, MBP, and TAU). It also focuses on the design mechanism of biosensing pathways of TBI biomarkers and nanotechnology integration methods, including the nanoparticles and nanostructures application in surface modification and improving the performance of the sensing procedures. Furthermore, through this study, the TBI-specific biosensors platform from the viewpoint of the transducer types and analysis output are evaluated. Finally, the current challenges and future perspectives regarding the development of biosensors for the early diagnosis of TBI are discussed. |
| first_indexed | 2024-04-11T06:01:27Z |
| format | Article |
| id | doaj.art-f7a9489aa4934be0b2a976aad6db2626 |
| institution | Directory Open Access Journal |
| issn | 2590-1370 |
| language | English |
| last_indexed | 2024-04-11T06:01:27Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biosensors and Bioelectronics: X |
| spelling | doaj.art-f7a9489aa4934be0b2a976aad6db26262022-12-22T04:41:40ZengElsevierBiosensors and Bioelectronics: X2590-13702022-12-0112100247Recent trends and innovations in biosensors development for biomarkers towards monitoring traumatic brain injuryMehrasa Rahimi Borumand0Fatemeh Babaloii1Seyedeh Azin Mirmotahari2Armin Salek Maghsoudi3Raheleh Torabi4Mojtaba Mojtahedzadeh5Parviz Norouzi6Mazda Rad-Malekshahi7Hamid Akbari Javar8Shokoufeh Hassani9Department of Pharmaceutical Biomaterials and Medical Biomaterial Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranDepartment of Pharmaceutical Biomaterials and Medical Biomaterial Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranDepartment of Pharmaceutical Biomaterials and Medical Biomaterial Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranDepartment of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranLaboratory of Bioanalysis, Institute of Biochemistry & Biophysics, Tehran University, Tehran, IranDepartment of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranCenter of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, IranDepartment of Pharmaceutical Biomaterials and Medical Biomaterial Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranDepartment of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Corresponding author. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran.Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran; Corresponding author. Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences (TUMS), Tehran, Iran.Traumatic brain injury (TBI) is a serious health concern and a leading cause of death in all age groups, especially adults. Although the processes of prevention, lifestyle modification, accident safety, and therapeutic management of TBI are constantly evolving, the development of accurate and trustworthy procedures for diagnosing brain damage, such as detecting specific biomarkers is still in its infancy. Early detection of TBI biomarkers, especially blood biomarkers, can improve treatment approaches and significantly reduce diagnostic costs. Different routine analytical methods, including ELISA and PCR techniques, have been used to detect TBI biomarkers. These procedures are generally complex, expensive, time-consuming, and require trained personnel. In contrast, biosensing techniques have been developed precisely through addressing the aforementioned weaknesses along with offering an accessible, affordable, rapid, highly sensitive, and specific approach. This comprehensive review presents the six main TBI biomarkers (S100β, NSE, GFAP, UCHL-1, MBP, and TAU). It also focuses on the design mechanism of biosensing pathways of TBI biomarkers and nanotechnology integration methods, including the nanoparticles and nanostructures application in surface modification and improving the performance of the sensing procedures. Furthermore, through this study, the TBI-specific biosensors platform from the viewpoint of the transducer types and analysis output are evaluated. Finally, the current challenges and future perspectives regarding the development of biosensors for the early diagnosis of TBI are discussed.http://www.sciencedirect.com/science/article/pii/S2590137022001406Traumatic brain injury (TBI)BiosensorBiomarkersClinical diagnostics |
| spellingShingle | Mehrasa Rahimi Borumand Fatemeh Babaloii Seyedeh Azin Mirmotahari Armin Salek Maghsoudi Raheleh Torabi Mojtaba Mojtahedzadeh Parviz Norouzi Mazda Rad-Malekshahi Hamid Akbari Javar Shokoufeh Hassani Recent trends and innovations in biosensors development for biomarkers towards monitoring traumatic brain injury Biosensors and Bioelectronics: X Traumatic brain injury (TBI) Biosensor Biomarkers Clinical diagnostics |
| title | Recent trends and innovations in biosensors development for biomarkers towards monitoring traumatic brain injury |
| title_full | Recent trends and innovations in biosensors development for biomarkers towards monitoring traumatic brain injury |
| title_fullStr | Recent trends and innovations in biosensors development for biomarkers towards monitoring traumatic brain injury |
| title_full_unstemmed | Recent trends and innovations in biosensors development for biomarkers towards monitoring traumatic brain injury |
| title_short | Recent trends and innovations in biosensors development for biomarkers towards monitoring traumatic brain injury |
| title_sort | recent trends and innovations in biosensors development for biomarkers towards monitoring traumatic brain injury |
| topic | Traumatic brain injury (TBI) Biosensor Biomarkers Clinical diagnostics |
| url | http://www.sciencedirect.com/science/article/pii/S2590137022001406 |
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