Cytogenetic and Biochemical Genetic Techniques for Personalized Drug Therapy in Europe
For many authorized drugs, accumulating scientific evidence supports testing for predictive biomarkers to apply personalized therapy and support preventive measures regarding adverse drug reactions and treatment failure. Here, we review cytogenetic and biochemical genetic testing methods that are av...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/11/7/1169 |
| _version_ | 1827601314418262016 |
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| author | Tatjana Huebner Catharina Scholl Michael Steffens |
| author_facet | Tatjana Huebner Catharina Scholl Michael Steffens |
| author_sort | Tatjana Huebner |
| collection | DOAJ |
| description | For many authorized drugs, accumulating scientific evidence supports testing for predictive biomarkers to apply personalized therapy and support preventive measures regarding adverse drug reactions and treatment failure. Here, we review cytogenetic and biochemical genetic testing methods that are available to guide therapy with drugs centrally approved in the European Union (EU). We identified several methods and combinations of techniques registered in the Genetic Testing Registry (GTR), which can be used to guide therapy with drugs for which pharmacogenomic-related information is provided in the European public assessment reports. Although this registry provides information on genetic tests offered worldwide, we identified limitations regarding standard techniques applied in clinical practice and the information on test validity rarely provided in the according sections. |
| first_indexed | 2024-03-09T04:52:31Z |
| format | Article |
| id | doaj.art-f7abf7b8ce4d4e66b5582b29dbcfbeb0 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T04:52:31Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-f7abf7b8ce4d4e66b5582b29dbcfbeb02023-12-03T13:10:02ZengMDPI AGDiagnostics2075-44182021-06-01117116910.3390/diagnostics11071169Cytogenetic and Biochemical Genetic Techniques for Personalized Drug Therapy in EuropeTatjana Huebner0Catharina Scholl1Michael Steffens2Research Division, Federal Institute for Drugs and Medical Devices, 53175 Bonn, North Rhine-Westphalia, GermanyResearch Division, Federal Institute for Drugs and Medical Devices, 53175 Bonn, North Rhine-Westphalia, GermanyResearch Division, Federal Institute for Drugs and Medical Devices, 53175 Bonn, North Rhine-Westphalia, GermanyFor many authorized drugs, accumulating scientific evidence supports testing for predictive biomarkers to apply personalized therapy and support preventive measures regarding adverse drug reactions and treatment failure. Here, we review cytogenetic and biochemical genetic testing methods that are available to guide therapy with drugs centrally approved in the European Union (EU). We identified several methods and combinations of techniques registered in the Genetic Testing Registry (GTR), which can be used to guide therapy with drugs for which pharmacogenomic-related information is provided in the European public assessment reports. Although this registry provides information on genetic tests offered worldwide, we identified limitations regarding standard techniques applied in clinical practice and the information on test validity rarely provided in the according sections.https://www.mdpi.com/2075-4418/11/7/1169companion diagnosticpersonalized therapypharmacogeneticspharmacogenomicsin vitro diagnosticregulation |
| spellingShingle | Tatjana Huebner Catharina Scholl Michael Steffens Cytogenetic and Biochemical Genetic Techniques for Personalized Drug Therapy in Europe Diagnostics companion diagnostic personalized therapy pharmacogenetics pharmacogenomics in vitro diagnostic regulation |
| title | Cytogenetic and Biochemical Genetic Techniques for Personalized Drug Therapy in Europe |
| title_full | Cytogenetic and Biochemical Genetic Techniques for Personalized Drug Therapy in Europe |
| title_fullStr | Cytogenetic and Biochemical Genetic Techniques for Personalized Drug Therapy in Europe |
| title_full_unstemmed | Cytogenetic and Biochemical Genetic Techniques for Personalized Drug Therapy in Europe |
| title_short | Cytogenetic and Biochemical Genetic Techniques for Personalized Drug Therapy in Europe |
| title_sort | cytogenetic and biochemical genetic techniques for personalized drug therapy in europe |
| topic | companion diagnostic personalized therapy pharmacogenetics pharmacogenomics in vitro diagnostic regulation |
| url | https://www.mdpi.com/2075-4418/11/7/1169 |
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