Soluble immune markers in the different phases of chronic hepatitis B virus infection
Abstract Chronic hepatitis B virus (HBV) infection may follow four different consecutive phases, which are defined by virology as well as biochemical markers and differ in terms of prognosis and need for antiviral treatment. Currently, host responses reflected by immune markers are not considered in...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-019-50729-5 |
| _version_ | 1818345816942706688 |
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| author | Steffen B. Wiegand Bastian Beggel Anika Wranke Elmira Aliabadi Jerzy Jaroszewicz Cheng-Jian Xu Yang Li Michael P. Manns Thomas Lengauer Heiner Wedemeyer Anke R. M. Kraft Christine S. Falk Markus Cornberg |
| author_facet | Steffen B. Wiegand Bastian Beggel Anika Wranke Elmira Aliabadi Jerzy Jaroszewicz Cheng-Jian Xu Yang Li Michael P. Manns Thomas Lengauer Heiner Wedemeyer Anke R. M. Kraft Christine S. Falk Markus Cornberg |
| author_sort | Steffen B. Wiegand |
| collection | DOAJ |
| description | Abstract Chronic hepatitis B virus (HBV) infection may follow four different consecutive phases, which are defined by virology as well as biochemical markers and differ in terms of prognosis and need for antiviral treatment. Currently, host responses reflected by immune markers are not considered in this definition. We aimed to study soluble immune markers and their distribution in different phases of chronic HBV infection. In this cross-sectional retrospective study, we investigated a panel of 14 soluble immune markers (SIM) including CXCL10 in 333 patients with chronic HBV infection. In a small cohort of HBeAg positive patients we analyzed SIM before and after HBeAg seroconversion and compared seroconverters to patients with unknown outcome. Significant differences were documented in the levels of several SIM between the four phases of chronic HBV infection. The most pronounced difference among all investigated SIM was observed for CXCL10 concentrations with highest levels in patients with hepatitis. TGF-β and IL-17 revealed different levels between HBeAg negative patients. HBeAg positive patients with HBeAg seroconversion presented higher amounts of IL-12 before seroconversion compared to HBeAg positive patients with unknown follow up. SIM such as CXCL10 but also IL-12, TGF-β and IL-17 may be useful markers to further characterize the phase of chronic HBV infection. |
| first_indexed | 2024-12-13T17:08:23Z |
| format | Article |
| id | doaj.art-f7ac612f63a345c6b2c5dd3549909b29 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-13T17:08:23Z |
| publishDate | 2019-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f7ac612f63a345c6b2c5dd3549909b292022-12-21T23:37:38ZengNature PortfolioScientific Reports2045-23222019-10-019111010.1038/s41598-019-50729-5Soluble immune markers in the different phases of chronic hepatitis B virus infectionSteffen B. Wiegand0Bastian Beggel1Anika Wranke2Elmira Aliabadi3Jerzy Jaroszewicz4Cheng-Jian Xu5Yang Li6Michael P. Manns7Thomas Lengauer8Heiner Wedemeyer9Anke R. M. Kraft10Christine S. Falk11Markus Cornberg12Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical SchoolUniversity of Applied SciencesDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical SchoolDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical SchoolDepartment of Infectious Diseases and Hepatology, Medical University of SilesiaDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical SchoolCentre for individualized infection medicine (CIIM)Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical SchoolGerman Centre for Infection Research (DZIF), partner-siteDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical SchoolDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical SchoolGerman Centre for Infection Research (DZIF), partner-siteDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical SchoolAbstract Chronic hepatitis B virus (HBV) infection may follow four different consecutive phases, which are defined by virology as well as biochemical markers and differ in terms of prognosis and need for antiviral treatment. Currently, host responses reflected by immune markers are not considered in this definition. We aimed to study soluble immune markers and their distribution in different phases of chronic HBV infection. In this cross-sectional retrospective study, we investigated a panel of 14 soluble immune markers (SIM) including CXCL10 in 333 patients with chronic HBV infection. In a small cohort of HBeAg positive patients we analyzed SIM before and after HBeAg seroconversion and compared seroconverters to patients with unknown outcome. Significant differences were documented in the levels of several SIM between the four phases of chronic HBV infection. The most pronounced difference among all investigated SIM was observed for CXCL10 concentrations with highest levels in patients with hepatitis. TGF-β and IL-17 revealed different levels between HBeAg negative patients. HBeAg positive patients with HBeAg seroconversion presented higher amounts of IL-12 before seroconversion compared to HBeAg positive patients with unknown follow up. SIM such as CXCL10 but also IL-12, TGF-β and IL-17 may be useful markers to further characterize the phase of chronic HBV infection.https://doi.org/10.1038/s41598-019-50729-5 |
| spellingShingle | Steffen B. Wiegand Bastian Beggel Anika Wranke Elmira Aliabadi Jerzy Jaroszewicz Cheng-Jian Xu Yang Li Michael P. Manns Thomas Lengauer Heiner Wedemeyer Anke R. M. Kraft Christine S. Falk Markus Cornberg Soluble immune markers in the different phases of chronic hepatitis B virus infection Scientific Reports |
| title | Soluble immune markers in the different phases of chronic hepatitis B virus infection |
| title_full | Soluble immune markers in the different phases of chronic hepatitis B virus infection |
| title_fullStr | Soluble immune markers in the different phases of chronic hepatitis B virus infection |
| title_full_unstemmed | Soluble immune markers in the different phases of chronic hepatitis B virus infection |
| title_short | Soluble immune markers in the different phases of chronic hepatitis B virus infection |
| title_sort | soluble immune markers in the different phases of chronic hepatitis b virus infection |
| url | https://doi.org/10.1038/s41598-019-50729-5 |
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