Phloroglucinol attenuates motor functional deficits in an animal model of Parkinson's disease by enhancing Nrf2 activity.

Phloroglucinol attenuates motor functional deficits in an animal model of Parkinson's disease by enhancing Nrf2 activity.

In this study, we investigated whether phloroglucinol (1,3,5-trihydroxybenzene) has therapeutic effects in cellular and animal model of Parkinson's disease (PD). PD is the second most common, chronic and progressive neurodegenerative disease, and is clinically characterized with motor dysfuncti...

Full description

Bibliographic Details
Main Authors:	Junghwa Ryu, Rui Zhang, Bo-Hyun Hong, Eun-Jung Yang, Kyoung Ah Kang, Moonseok Choi, Ki Cheon Kim, Su-Jin Noh, Hee Soo Kim, Nam-Ho Lee, Jin Won Hyun, Hye-Sun Kim
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3748069?pdf=render

Similar Items

Phloroglucinol Attenuates the Cognitive Deficits of the 5XFAD Mouse Model of Alzheimer's Disease.
by: Eun-Jeong Yang, et al.
Published: (2015-01-01)

Phloroglucinol Exerts Protective Effects Against Oxidative Stress–Induced Cell Damage in SH-SY5Y Cells
by: Hee Soo Kim, et al.
Published: (2012-01-01)

Phloroglucinol Inhibits Oxidative-Stress-Induced Cytotoxicity in C2C12 Murine Myoblasts through Nrf-2-Mediated Activation of HO-1
by: Cheol Park, et al.
Published: (2023-02-01)

Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosis through Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes
by: Cheol Park, et al.
Published: (2019-04-01)

Phloroglucinol attenuates oligomeric amyloid beta peptide1-42-induced astrocytic activation by reducing oxidative stress
by: Eun-Jeong Yang, et al.
Published: (2021-04-01)

Phloroglucinol Attenuates DNA Damage and Apoptosis Induced by Oxidative Stress in Human Retinal Pigment Epithelium ARPE-19 Cells by Blocking the Production of Mitochondrial ROS
by: Cheol Park, et al.
Published: (2022-11-01)

Protective Effect of Pyrogallol-Phloroglucinol-6,6-Bieckol from <i>Ecklonia cava</i> on Monocyte-Associated Vascular Dysfunction
by: Seyeon Oh, et al.
Published: (2018-11-01)

Effectiveness of oral phloroglucinol as a premedication for unsedated esophagogastroduodenoscopy: A prospective, double-blinded, placebo-controlled, randomized trial
by: HyeIn Jung, et al.
Published: (2021-01-01)

Astrocytic Nrf2 Mediates the Neuroprotective and Anti-Inflammatory Effects of Nootkatone in an MPTP-Induced Parkinson’s Disease Mouse Model
by: Jung-Eun Park, et al.
Published: (2023-11-01)

Isolation and identification of new compound, 2,7″-phloroglucinol-6,6′-bieckol from brown algae, Ecklonia cava and its antioxidant effect
by: Sung-Myung Kang, et al.
Published: (2012-01-01)

Inhibition of STAT3 phosphorylation attenuates impairments in learning and memory in 5XFAD mice, an animal model of Alzheimer's disease
by: Moonseok Choi, et al.
Published: (2020-08-01)

Effect of Obesity and High-Density Lipoprotein Concentration on the Pathological Characteristics of Alzheimer’s Disease in High-Fat Diet-Fed Mice
by: Moonseok Choi, et al.
Published: (2022-10-01)

3-Bromo-4,5-dihydroxybenzaldehyde Enhances the Level of Reduced Glutathione via the Nrf2-Mediated Pathway in Human Keratinocytes
by: Ki Cheon Kim, et al.
Published: (2017-09-01)

Increased Glutathione Synthesis Following Nrf2 Activation by Vanadyl Sulfate in Human Chang Liver Cells
by: Jin Won Hyun, et al.
Published: (2011-12-01)

Phloroglucinol Improves Direct Rooting of In Vitro Cultured Apple Rootstocks M9 and M26
by: Jin-Ho Kim, et al.
Published: (2020-07-01)

Anaerobic phloroglucinol degradation by Clostridium scatologenes
by: Yan Zhou, et al.
Published: (2023-08-01)

Phloroglucinol Derivatives from <i>Dryopteris crassirhizoma</i> as Potent Xanthine Oxidase Inhibitors
by: Heung Joo Yuk, et al.
Published: (2020-12-01)

Fucoxanthin Enhances the Level of Reduced Glutathione via the Nrf2-Mediated Pathway in Human Keratinocytes
by: Jian Zheng, et al.
Published: (2014-07-01)

Neuritin attenuates cognitive function impairments in tg2576 mouse model of Alzheimer's disease.
by: Yoori Choi, et al.
Published: (2014-01-01)

Pyrogallol-Phloroglucinol-6,6-Bieckolon Attenuates Vascular Smooth Muscle Cell Proliferation and Phenotype Switching in Hyperlipidemia through Modulation of Chemokine Receptor 5
by: Seyeon Oh, et al.
Published: (2020-07-01)

Peroxidasin Inhibition by Phloroglucinol and Other Peroxidase Inhibitors
by: Martina Paumann-Page, et al.
Published: (2023-12-01)

New expression system to increase the yield of phloroglucinol
by: Shan Yuan, et al.
Published: (2020-01-01)

Phytol Suppresses Osteoclast Differentiation and Oxidative Stress through Nrf2/HO-1 Regulation in RANKL-Induced RAW264.7 Cells
by: Eun-Nam Kim, et al.
Published: (2022-11-01)

Triphlorethol-A from Ecklonia cava Up-Regulates the Oxidant Sensitive 8-Oxoguanine DNA Glycosylase 1
by: Ki Cheon Kim, et al.
Published: (2014-10-01)

CDDO-Me Attenuates Astroglial Autophagy via Nrf2-, ERK1/2-SP1- and Src-CK2-PTEN-PI3K/AKT-Mediated Signaling Pathways in the Hippocampus of Chronic Epilepsy Rats
by: Ji-Eun Kim, et al.
Published: (2021-04-01)

Attenuating Effects of Pyrogallol-Phloroglucinol-6,6-Bieckol on Vascular Smooth Muscle Cell Phenotype Changes to Osteoblastic Cells and Vascular Calcification Induced by High Fat Diet
by: Myeongjoo Son, et al.
Published: (2020-09-01)

An in vitro synthetic biosystem based on acetate for production of phloroglucinol
by: Rubing Zhang, et al.
Published: (2017-08-01)

Synthesis and Anti-Inflammatory Activities of Phloroglucinol-Based Derivatives
by: Ning Li, et al.
Published: (2018-12-01)

Acid Catalysed Condesation of Phloroglucinol and Acetone-Kinetics and Mechanism
by: H.C. Malhotra, et al.
Published: (1991-06-01)

Micropropagation and Effect of Phloroglucinol on Rooting of Diospyros crassiflora Hiern
by: Alvine Ornella Tchouga, et al.
Published: (2020-03-01)

EGCG Attenuates CA1 Neuronal Death by Regulating GPx1, NF-κB S536 Phosphorylation and Mitochondrial Dynamics in the Rat Hippocampus following Status Epilepticus
by: Ji-Eun Kim, et al.
Published: (2023-04-01)

Impressic Acid Attenuates the Lipopolysaccharide-Induced Inflammatory Response by Activating the AMPK/GSK3β/Nrf2 Axis in RAW264.7 Macrophages
by: Gi Ho Lee, et al.
Published: (2021-01-01)

Acupuncture Treatment in Clinical Studies for Parkinson’s Disease : A Literature Review
by: Soo Ah Sohn, et al.
Published: (2018-11-01)

Phloroglucinol-Gold and -Zinc Oxide Nanoparticles: Antibiofilm and Antivirulence Activities towards <i>Pseudomonas</i> <i>aeruginosa</i> PAO1
by: Fazlurrahman Khan, et al.
Published: (2021-10-01)

Inhibitory Effect of LGS and ODE Isolated from the Twigs of <i>Syringa oblata</i> subsp. <i>dilatata</i> on RANKL-Induced Osteoclastogenesis in Macrophage Cells
by: Ga-Ram Kim, et al.
Published: (2021-03-01)

Protection against Oxidative Stress-Induced Apoptosis by Fermented Sea Tangle (<i>Laminaria japonica</i> Aresch) in Osteoblastic MC3T3-E1 Cells through Activation of Nrf2 Signaling Pathway
by: So Young Kim, et al.
Published: (2021-11-01)

Characterization and Spike Gene Analysis of a Candidate Attenuated Live Bovine Coronavirus Vaccine
by: Gyu-Nam Park, et al.
Published: (2024-01-01)

CDDO-Me Attenuates Vasogenic Edema and Astroglial Death by Regulating NF-κB p65 Phosphorylations and Nrf2 Expression Following Status Epilepticus
by: Min-Ju Kim, et al.
Published: (2019-09-01)

Paeoniflorin Attenuates Lipopolysaccharide-Induced Cognitive Dysfunction by Inhibition of Amyloidogenesis in Mice
by: Hui Wen Meng, et al.
Published: (2023-03-01)

Rescue of a Live-Attenuated Porcine Epidemic Diarrhea Virus HSGP Strain Using a Virulent Strain and a Partially Attenuated Strain
by: Sok Song, et al.
Published: (2023-07-01)