Decreased hepatic thyroid hormone signaling in systemic and liver-specific but not brain-specific accelerated aging due to DNA repair deficiency in mice

Decreased hepatic thyroid hormone signaling in systemic and liver-specific but not brain-specific accelerated aging due to DNA repair deficiency in mice

Background: Thyroid hormone signaling is essential for development, metabolism, and response to stress but declines during aging, the cause of which is unknown. DNA damage accumulating with time is a main cause of aging, driving many age-related diseases. Previous studies in normal and premature agi...

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Bibliographic Details
Main Authors: Sander Barnhoorn, Marcel E Meima, Robin P Peeters, Veerle M Darras, Selmar Leeuwenburgh, Jan H J Hoeijmakers, Wilbert P Vermeij, W Edward Visser
Format: Article
Language:English
Published: Bioscientifica 2023-11-01
Series:European Thyroid Journal
Subjects:
thyroid hormone
deiodinase
aging
progeria
dna damage
nucleotide excision repair
liver
Online Access:https://etj.bioscientifica.com/view/journals/etj/12/6/ETJ-22-0231.xml

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