Tumor-infiltrating mast cells stimulate ICOS+ regulatory T cells through an IL-33 and IL-2 axis to promote gastric cancer progression

Tumor-infiltrating mast cells stimulate ICOS+ regulatory T cells through an IL-33 and IL-2 axis to promote gastric cancer progression

Introduction: In solid tumors, regulatory T cell (Treg) and mast cell perform different roles depending on the microenvironment. Nevertheless, mast cell and Treg-mediated interactions in gastric cancer (GC) are unclear, as are their regulation, function, and clinical significance. Objective: The pre...

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Bibliographic Details
Main Authors: Yipin Lv, Wenqing Tian, Yongsheng Teng, Pan Wang, Yongliang Zhao, Zhengyan Li, Shanhong Tang, Weisan Chen, Rui Xie, Muhan Lü, Yuan Zhuang
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Journal of Advanced Research
Subjects:
Gastric cancer
IL-33
Mast cells
IL-2
ICOS+ regulatory T cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123223001194

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