R-spondin family biology and emerging linkages to cancer
AbstractThe R-spondin protein family comprises four members (RSPO1-4), which are agonists of the canonical Wnt/β-catenin pathway. Emerging evidence revealed that RSPOs should not only be viewed as agonists of the Wnt/β-catenin pathway but also as regulators for tumor development and progression. Abe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2023.2166981 |
| _version_ | 1797353707165188096 |
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| author | Zhimin He Jialin Zhang Jianzhong Ma Lei Zhao Xiaodong Jin Hongbin Li |
| author_facet | Zhimin He Jialin Zhang Jianzhong Ma Lei Zhao Xiaodong Jin Hongbin Li |
| author_sort | Zhimin He |
| collection | DOAJ |
| description | AbstractThe R-spondin protein family comprises four members (RSPO1-4), which are agonists of the canonical Wnt/β-catenin pathway. Emerging evidence revealed that RSPOs should not only be viewed as agonists of the Wnt/β-catenin pathway but also as regulators for tumor development and progression. Aberrant expression of RSPOs is related to tumorigenesis and tumor development in multiple cancers and their expression of RSPOs has also been correlated with anticancer immune cell signatures. More importantly, the role of RSPOs as potential target therapies and their implication in cancer progressions has been studied in the preclinical and clinical settings. These findings highlight the possible therapeutic value of RSPOs in cancer medicine. However, the expression pattern, effects, and mechanisms of RSPO proteins in cancer remain elusive. Investigating the many roles of RSPOs is likely to expand and improve our understanding of the oncogenic mechanisms mediated by RSPOs. Here, we reviewed the recent advances in the functions and underlying molecular mechanisms of RSPOs in tumor development, cancer microenvironment regulation, and immunity, and discussed the therapeutic potential of targeting RSPOs for cancer treatment. In addition, we also explored the biological feature and clinical relevance of RSPOs in cancer mutagenesis, transcriptional regulation, and immune correlation by bioinformatics analysis.KEY MESSAGESAberrant expressions of RSPOs are detected in various human malignancies and are always correlated with oncogenesis.Although extensive studies of RSPOs have been conducted, their precise molecular mechanism remains poorly understood.Bioinformatic analysis revealed that RSPOs may play a part in the development of the immune composition of the tumor microenvironment. |
| first_indexed | 2024-03-08T13:34:55Z |
| format | Article |
| id | doaj.art-f7b367d7244945e8a7d81246a5597265 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T13:34:55Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-f7b367d7244945e8a7d81246a55972652024-01-16T19:13:22ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-0155142844610.1080/07853890.2023.2166981R-spondin family biology and emerging linkages to cancerZhimin He0Jialin Zhang1Jianzhong Ma2Lei Zhao3Xiaodong Jin4Hongbin Li5School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, ChinaSchool of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, ChinaSchool of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, ChinaKey Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou, ChinaInstitute of Modern Physics, Chinese Academy of Sciences, Lanzhou, ChinaSchool of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, ChinaAbstractThe R-spondin protein family comprises four members (RSPO1-4), which are agonists of the canonical Wnt/β-catenin pathway. Emerging evidence revealed that RSPOs should not only be viewed as agonists of the Wnt/β-catenin pathway but also as regulators for tumor development and progression. Aberrant expression of RSPOs is related to tumorigenesis and tumor development in multiple cancers and their expression of RSPOs has also been correlated with anticancer immune cell signatures. More importantly, the role of RSPOs as potential target therapies and their implication in cancer progressions has been studied in the preclinical and clinical settings. These findings highlight the possible therapeutic value of RSPOs in cancer medicine. However, the expression pattern, effects, and mechanisms of RSPO proteins in cancer remain elusive. Investigating the many roles of RSPOs is likely to expand and improve our understanding of the oncogenic mechanisms mediated by RSPOs. Here, we reviewed the recent advances in the functions and underlying molecular mechanisms of RSPOs in tumor development, cancer microenvironment regulation, and immunity, and discussed the therapeutic potential of targeting RSPOs for cancer treatment. In addition, we also explored the biological feature and clinical relevance of RSPOs in cancer mutagenesis, transcriptional regulation, and immune correlation by bioinformatics analysis.KEY MESSAGESAberrant expressions of RSPOs are detected in various human malignancies and are always correlated with oncogenesis.Although extensive studies of RSPOs have been conducted, their precise molecular mechanism remains poorly understood.Bioinformatic analysis revealed that RSPOs may play a part in the development of the immune composition of the tumor microenvironment.https://www.tandfonline.com/doi/10.1080/07853890.2023.2166981R-spondinWNT signalingLGR4/5/6tumor microenvironmenttargeted therapybiomarker |
| spellingShingle | Zhimin He Jialin Zhang Jianzhong Ma Lei Zhao Xiaodong Jin Hongbin Li R-spondin family biology and emerging linkages to cancer Annals of Medicine R-spondin WNT signaling LGR4/5/6 tumor microenvironment targeted therapy biomarker |
| title | R-spondin family biology and emerging linkages to cancer |
| title_full | R-spondin family biology and emerging linkages to cancer |
| title_fullStr | R-spondin family biology and emerging linkages to cancer |
| title_full_unstemmed | R-spondin family biology and emerging linkages to cancer |
| title_short | R-spondin family biology and emerging linkages to cancer |
| title_sort | r spondin family biology and emerging linkages to cancer |
| topic | R-spondin WNT signaling LGR4/5/6 tumor microenvironment targeted therapy biomarker |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2023.2166981 |
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