Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid

This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and targ...

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Bibliographic Details
Main Authors: Xiao Jia Yin, Guan Hong Xu, Xu Sun, Yan Peng, Xing Ji, Ke Jiang, Fei Li
Format: Article
Language:English
Published: MDPI AG 2010-06-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/15/6/4261/
Description
Summary:This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and target molecule were characterized by 1H-NMR, 13C-NMR, MS and the purities of all the compounds were determined by HPLC.
ISSN:1420-3049