MHC Class I Downregulation in Cancer: Underlying Mechanisms and Potential Targets for Cancer Immunotherapy

MHC Class I Downregulation in Cancer: Underlying Mechanisms and Potential Targets for Cancer Immunotherapy

In recent years, major advances have been made in cancer immunotherapy. This has led to significant improvement in prognosis of cancer patients, especially in the hematological setting. Nonetheless, translation of these successes to solid tumors was found difficult. One major mechanism through which...

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Bibliographic Details
Main Authors: Annelisa M. Cornel, Iris L. Mimpen, Stefan Nierkens
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
MHC-I downregulation
cancer immunotherapy
antigen presentation
tumor immunogenicity
adaptive immune involvement
Online Access:https://www.mdpi.com/2072-6694/12/7/1760

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