Efficacy and safety of adjunctive padsevonil in adults with drug‐resistant focal epilepsy: Results from two double‐blind, randomized, placebo‐controlled trials

Efficacy and safety of adjunctive padsevonil in adults with drug‐resistant focal epilepsy: Results from two double‐blind, randomized, placebo‐controlled trials

Abstract Objective To characterize efficacy, safety/tolerability, and pharmacokinetics of padsevonil (PSL) administered concomitantly with ≤3 antiseizure medications (ASMs) for observable focal seizures in adults with drug‐resistant epilepsy in two multicenter, randomized, double‐blind, placebo‐cont...

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Bibliographic Details
Main Authors: Michael Rademacher, Manuel Toledo, Wim Van Paesschen, Kore K. Liow, Ivan G. Milanov, Maria‐Luise Esch, Nan Wang, Merran MacPherson, William J. Byrnes, Timothy D. C. Minh, Elizabeth Webster, Konrad J. Werhahn
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Epilepsia Open
Subjects:
antiepileptic drug
antiseizure medication
dual mechanism of action
focal seizure
synaptic vesicle protein 2
tolerability
Online Access:https://doi.org/10.1002/epi4.12656

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