High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD
Overconsumption of carbohydrates and lipids are well known to cause nonalcoholic fatty liver disease (NAFLD), while the role of nutritional protein intake is less clear. In Western diet, meat and other animal products are the main protein source, with varying concentrations of specific amino acids....
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2020-05-01
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| Series: | Hepatology Communications |
| Online Access: | https://doi.org/10.1002/hep4.1509 |
| _version_ | 1797936933571133440 |
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| author | Sonja Lang Anna Martin Fedja Farowski Hilmar Wisplinghoff Maria J.G.T. Vehreschild Jinyuan Liu Marcin Krawczyk Angela Nowag Anne Kretzschmar Jens Herweg Bernd Schnabl Xin M. Tu Frank Lammert Tobias Goeser Frank Tacke Kathrin Heinzer Philipp Kasper Hans‐Michael Steffen Münevver Demir |
| author_facet | Sonja Lang Anna Martin Fedja Farowski Hilmar Wisplinghoff Maria J.G.T. Vehreschild Jinyuan Liu Marcin Krawczyk Angela Nowag Anne Kretzschmar Jens Herweg Bernd Schnabl Xin M. Tu Frank Lammert Tobias Goeser Frank Tacke Kathrin Heinzer Philipp Kasper Hans‐Michael Steffen Münevver Demir |
| author_sort | Sonja Lang |
| collection | DOAJ |
| description | Overconsumption of carbohydrates and lipids are well known to cause nonalcoholic fatty liver disease (NAFLD), while the role of nutritional protein intake is less clear. In Western diet, meat and other animal products are the main protein source, with varying concentrations of specific amino acids. Whether the amount or composition of protein intake is associated with a higher risk for disease severity has not yet been examined. In this study, we investigated associations of dietary components with histological disease activity by analyzing detailed 14‐day food records in a cohort of 61 patients with biopsy‐proven NAFLD. Furthermore, we used 16S ribosomal RNA gene sequencing to detect associations with different abundances of the gut microbiota with dietary patterns. Patients with definite nonalcoholic steatohepatitis (NAFLD activity score of 5‐8 on liver biopsy) had a significantly higher daily relative intake of protein compared with patients with a NAFLD activity score of 0‐4 (18.0% vs. 15.8% of daily protein‐based calories, P = 0.018). After adjustment for several potentially confounding factors, a higher protein intake (≥17.3% of daily protein‐based calories) remained associated with definite nonalcoholic steatohepatitis, with an odds ratio of 5.09 (95% confidence interval 1.22‐21.25, P = 0.026). This association was driven primarily by serine, glycine, arginine, proline, phenylalanine, and methionine. A higher protein intake correlated with a lower Bacteroides abundance and an altered abundance of several other bacterial taxa. Conclusion: A high protein intake was independently associated with more active and severe histological disease activity in patients with NAFLD. Further studies are needed to investigate the potential harmful role of dietary amino acids on NAFLD, with special attention to meat as their major source. |
| first_indexed | 2024-04-10T18:36:57Z |
| format | Article |
| id | doaj.art-f7b838653ae0472fb8e62f4afbe99923 |
| institution | Directory Open Access Journal |
| issn | 2471-254X |
| language | English |
| last_indexed | 2024-04-10T18:36:57Z |
| publishDate | 2020-05-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Hepatology Communications |
| spelling | doaj.art-f7b838653ae0472fb8e62f4afbe999232023-02-02T01:02:54ZengWolters Kluwer Health/LWWHepatology Communications2471-254X2020-05-014568169510.1002/hep4.1509High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLDSonja Lang0Anna Martin1Fedja Farowski2Hilmar Wisplinghoff3Maria J.G.T. Vehreschild4Jinyuan Liu5Marcin Krawczyk6Angela Nowag7Anne Kretzschmar8Jens Herweg9Bernd Schnabl10Xin M. Tu11Frank Lammert12Tobias Goeser13Frank Tacke14Kathrin Heinzer15Philipp Kasper16Hans‐Michael Steffen17Münevver Demir18Department of Gastroenterology and Hepatology Faculty of Medicine University of Cologne University Hospital Cologne Cologne GermanyDepartment of Gastroenterology and Hepatology Faculty of Medicine University of Cologne University Hospital Cologne Cologne GermanyDepartment of Internal Medicine Faculty of Medicine University of Cologne University Hospital Cologne Cologne GermanyWisplinghoff Laboratories Cologne GermanyDepartment of Internal Medicine Faculty of Medicine University of Cologne University Hospital Cologne Cologne GermanyDivision of Biostatistics and Bioinformatics Department of Family Medicine and Public Health University of California San Diego San Diego CADepartment of Medicine Saarland University Medical Center Homburg GermanyWisplinghoff Laboratories Cologne GermanyWisplinghoff Laboratories Cologne GermanyWisplinghoff Laboratories Cologne GermanyDepartment of Medicine University of California San Diego La Jolla CADivision of Biostatistics and Bioinformatics Department of Family Medicine and Public Health University of California San Diego San Diego CADepartment of Medicine Saarland University Medical Center Homburg GermanyDepartment of Gastroenterology and Hepatology Faculty of Medicine University of Cologne University Hospital Cologne Cologne GermanyDepartment of Hepatology and Gastroenterology Charité University Medicine Campus Virchow ClinicBerlin GermanyDepartment of Gastroenterology and Hepatology Faculty of Medicine University of Cologne University Hospital Cologne Cologne GermanyDepartment of Gastroenterology and Hepatology Faculty of Medicine University of Cologne University Hospital Cologne Cologne GermanyDepartment of Gastroenterology and Hepatology Faculty of Medicine University of Cologne University Hospital Cologne Cologne GermanyDepartment of Gastroenterology and Hepatology Faculty of Medicine University of Cologne University Hospital Cologne Cologne GermanyOverconsumption of carbohydrates and lipids are well known to cause nonalcoholic fatty liver disease (NAFLD), while the role of nutritional protein intake is less clear. In Western diet, meat and other animal products are the main protein source, with varying concentrations of specific amino acids. Whether the amount or composition of protein intake is associated with a higher risk for disease severity has not yet been examined. In this study, we investigated associations of dietary components with histological disease activity by analyzing detailed 14‐day food records in a cohort of 61 patients with biopsy‐proven NAFLD. Furthermore, we used 16S ribosomal RNA gene sequencing to detect associations with different abundances of the gut microbiota with dietary patterns. Patients with definite nonalcoholic steatohepatitis (NAFLD activity score of 5‐8 on liver biopsy) had a significantly higher daily relative intake of protein compared with patients with a NAFLD activity score of 0‐4 (18.0% vs. 15.8% of daily protein‐based calories, P = 0.018). After adjustment for several potentially confounding factors, a higher protein intake (≥17.3% of daily protein‐based calories) remained associated with definite nonalcoholic steatohepatitis, with an odds ratio of 5.09 (95% confidence interval 1.22‐21.25, P = 0.026). This association was driven primarily by serine, glycine, arginine, proline, phenylalanine, and methionine. A higher protein intake correlated with a lower Bacteroides abundance and an altered abundance of several other bacterial taxa. Conclusion: A high protein intake was independently associated with more active and severe histological disease activity in patients with NAFLD. Further studies are needed to investigate the potential harmful role of dietary amino acids on NAFLD, with special attention to meat as their major source.https://doi.org/10.1002/hep4.1509 |
| spellingShingle | Sonja Lang Anna Martin Fedja Farowski Hilmar Wisplinghoff Maria J.G.T. Vehreschild Jinyuan Liu Marcin Krawczyk Angela Nowag Anne Kretzschmar Jens Herweg Bernd Schnabl Xin M. Tu Frank Lammert Tobias Goeser Frank Tacke Kathrin Heinzer Philipp Kasper Hans‐Michael Steffen Münevver Demir High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD Hepatology Communications |
| title | High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD |
| title_full | High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD |
| title_fullStr | High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD |
| title_full_unstemmed | High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD |
| title_short | High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD |
| title_sort | high protein intake is associated with histological disease activity in patients with nafld |
| url | https://doi.org/10.1002/hep4.1509 |
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