CD2 Immunobiology
The glycoprotein CD2 is a costimulatory receptor expressed mainly on T and NK cells that binds to LFA3, a cell surface protein expressed on e.g., antigen-presenting cells. CD2 has an important role in the formation and organization of the immunological synapse that is formed between T cells and anti...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01090/full |
| _version_ | 1818495858007605248 |
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| author | Christian Binder Christian Binder Filip Cvetkovski Felix Sellberg Felix Sellberg Stefan Berg Horacio Paternina Visbal Horacio Paternina Visbal David H. Sachs David H. Sachs Erik Berglund Erik Berglund David Berglund David Berglund |
| author_facet | Christian Binder Christian Binder Filip Cvetkovski Felix Sellberg Felix Sellberg Stefan Berg Horacio Paternina Visbal Horacio Paternina Visbal David H. Sachs David H. Sachs Erik Berglund Erik Berglund David Berglund David Berglund |
| author_sort | Christian Binder |
| collection | DOAJ |
| description | The glycoprotein CD2 is a costimulatory receptor expressed mainly on T and NK cells that binds to LFA3, a cell surface protein expressed on e.g., antigen-presenting cells. CD2 has an important role in the formation and organization of the immunological synapse that is formed between T cells and antigen-presenting cells upon cell-cell conjugation and associated intracellular signaling. CD2 expression is upregulated on memory T cells as well as activated T cells and plays an important role in activation of memory T cells despite the coexistence of several other costimulatory pathways. Anti-CD2 monoclonal antibodies have been shown to induce immune modulatory effects in vitro and clinical studies have proven the safety and efficacy of CD2-targeting biologics. Investigators have highlighted that the lack of attention to the CD2/LFA3 costimulatory pathway is a missed opportunity. Overall, CD2 is an attractive target for monoclonal antibodies intended for treatment of pathologies characterized by undesired T cell activation and offers an avenue to more selectively target memory T cells while favoring immune regulation. |
| first_indexed | 2024-12-10T18:26:17Z |
| format | Article |
| id | doaj.art-f7b94ce0ad6b470fa0ea4e7a4ec1e524 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T18:26:17Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f7b94ce0ad6b470fa0ea4e7a4ec1e5242022-12-22T01:38:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-06-011110.3389/fimmu.2020.01090533081CD2 ImmunobiologyChristian Binder0Christian Binder1Filip Cvetkovski2Felix Sellberg3Felix Sellberg4Stefan Berg5Horacio Paternina Visbal6Horacio Paternina Visbal7David H. Sachs8David H. Sachs9Erik Berglund10Erik Berglund11David Berglund12David Berglund13Department of Immunology, Genetics and Pathology, Section of Clinical Immunology, Uppsala University, Uppsala, SwedenResearch and Development, ITB-Med AB, Stockholm, SwedenResearch and Development, ITB-Med AB, Stockholm, SwedenDepartment of Immunology, Genetics and Pathology, Section of Clinical Immunology, Uppsala University, Uppsala, SwedenResearch and Development, ITB-Med AB, Stockholm, SwedenResearch and Development, ITB-Med AB, Stockholm, SwedenDepartment of Immunology, Genetics and Pathology, Section of Clinical Immunology, Uppsala University, Uppsala, SwedenResearch and Development, ITB-Med AB, Stockholm, SwedenResearch and Development, ITB-Med AB, Stockholm, SwedenDepartment of Medicine, Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, United StatesResearch and Development, ITB-Med AB, Stockholm, SwedenDivision of Transplantation Surgery, CLINTEC, Karolinska Institute, and Department of Transplantation Surgery, Karolinska University Hospital, Stockholm, SwedenDepartment of Immunology, Genetics and Pathology, Section of Clinical Immunology, Uppsala University, Uppsala, SwedenResearch and Development, ITB-Med AB, Stockholm, SwedenThe glycoprotein CD2 is a costimulatory receptor expressed mainly on T and NK cells that binds to LFA3, a cell surface protein expressed on e.g., antigen-presenting cells. CD2 has an important role in the formation and organization of the immunological synapse that is formed between T cells and antigen-presenting cells upon cell-cell conjugation and associated intracellular signaling. CD2 expression is upregulated on memory T cells as well as activated T cells and plays an important role in activation of memory T cells despite the coexistence of several other costimulatory pathways. Anti-CD2 monoclonal antibodies have been shown to induce immune modulatory effects in vitro and clinical studies have proven the safety and efficacy of CD2-targeting biologics. Investigators have highlighted that the lack of attention to the CD2/LFA3 costimulatory pathway is a missed opportunity. Overall, CD2 is an attractive target for monoclonal antibodies intended for treatment of pathologies characterized by undesired T cell activation and offers an avenue to more selectively target memory T cells while favoring immune regulation.https://www.frontiersin.org/article/10.3389/fimmu.2020.01090/fullCD2CD58LFA-3 (lymphocyte functional antigen-3)T cell activationcostimulationcostimulation blockade |
| spellingShingle | Christian Binder Christian Binder Filip Cvetkovski Felix Sellberg Felix Sellberg Stefan Berg Horacio Paternina Visbal Horacio Paternina Visbal David H. Sachs David H. Sachs Erik Berglund Erik Berglund David Berglund David Berglund CD2 Immunobiology Frontiers in Immunology CD2 CD58 LFA-3 (lymphocyte functional antigen-3) T cell activation costimulation costimulation blockade |
| title | CD2 Immunobiology |
| title_full | CD2 Immunobiology |
| title_fullStr | CD2 Immunobiology |
| title_full_unstemmed | CD2 Immunobiology |
| title_short | CD2 Immunobiology |
| title_sort | cd2 immunobiology |
| topic | CD2 CD58 LFA-3 (lymphocyte functional antigen-3) T cell activation costimulation costimulation blockade |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.01090/full |
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