The effect of celery (Apium graveolens) powder on cardiometabolic factors in overweight/obese individuals with type 2 diabetes mellitus: A pilot randomized, double‐blinded, placebo‐controlled clinical trial
Abstract Celery (Apium graveolens) was shown to have beneficial effects on cardiometabolic factors in animal models. As the progression of type 2 diabetes mellitus (T2DM) adversely affects cardiometabolic factors, we aimed to assess the effects of celery powder on glycemic and anthropometric indices...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | Food Science & Nutrition |
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| Online Access: | https://doi.org/10.1002/fsn3.3493 |
| _version_ | 1797688641901821952 |
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| author | Mohammad Ali Mohsenpour Mahsa Samadani Zeinab Shahsavani Mohammad Taghi Golmakani Gholam Reza Pishdad Maryam Ekramzadeh |
| author_facet | Mohammad Ali Mohsenpour Mahsa Samadani Zeinab Shahsavani Mohammad Taghi Golmakani Gholam Reza Pishdad Maryam Ekramzadeh |
| author_sort | Mohammad Ali Mohsenpour |
| collection | DOAJ |
| description | Abstract Celery (Apium graveolens) was shown to have beneficial effects on cardiometabolic factors in animal models. As the progression of type 2 diabetes mellitus (T2DM) adversely affects cardiometabolic factors, we aimed to assess the effects of celery powder on glycemic and anthropometric indices, lipid profile, liver function, oxidative stress, and blood pressure of individuals with T2DM. In a pilot randomized, double‐blinded, placebo‐controlled clinical trial, 50 eligible adults with T2DM were randomly divided into two groups of intervention and control to consume either 750 mg of celery powder (obtained from fresh celery) or placebo along with a low‐calorie diet for 12 weeks, respectively. Dietary intake, physical activity, and cardiometabolic factors were assessed before and at the end of the study. Thirty‐six patients finished the study (18 in each group). Consumption of celery powder significantly reduced body fat percentage (p = .021). Between‐group analysis for changes in cardiometabolic factors did not show significant differences. Although malondialdehyde was reduced in the intervention group and increased in the control group, between‐group changes were not significant. Although the insulin‐level change was statistically insignificant, a clinical improvement was observed in the intervention group. A 750‐mg daily supplementation of celery powder for 12 weeks did not improve the cardiometabolic factors of patients with T2DM. Further studies are suggested. |
| first_indexed | 2024-03-12T01:33:46Z |
| format | Article |
| id | doaj.art-f7bab0dc74ad49139b7694e55d5251f4 |
| institution | Directory Open Access Journal |
| issn | 2048-7177 |
| language | English |
| last_indexed | 2024-03-12T01:33:46Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Science & Nutrition |
| spelling | doaj.art-f7bab0dc74ad49139b7694e55d5251f42023-09-11T13:25:12ZengWileyFood Science & Nutrition2048-71772023-09-011195351536310.1002/fsn3.3493The effect of celery (Apium graveolens) powder on cardiometabolic factors in overweight/obese individuals with type 2 diabetes mellitus: A pilot randomized, double‐blinded, placebo‐controlled clinical trialMohammad Ali Mohsenpour0Mahsa Samadani1Zeinab Shahsavani2Mohammad Taghi Golmakani3Gholam Reza Pishdad4Maryam Ekramzadeh5Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences Shiraz University of Medical Sciences Shiraz IranDepartment of Nutrition, School of Allied Medical Sciences Ahvaz Jundishapur University of Medical Sciences Ahvaz IranDepartment of Community Nutrition, School of Nutrition and Food Sciences Shiraz University of Medical Sciences Shiraz IranDepartment of Food Science and Technology, School of Agriculture Shiraz University Shiraz IranEndocrine and Metabolism Research Center Shiraz University of Medical Sciences Shiraz IranNutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences Shiraz University of Medical Sciences Shiraz IranAbstract Celery (Apium graveolens) was shown to have beneficial effects on cardiometabolic factors in animal models. As the progression of type 2 diabetes mellitus (T2DM) adversely affects cardiometabolic factors, we aimed to assess the effects of celery powder on glycemic and anthropometric indices, lipid profile, liver function, oxidative stress, and blood pressure of individuals with T2DM. In a pilot randomized, double‐blinded, placebo‐controlled clinical trial, 50 eligible adults with T2DM were randomly divided into two groups of intervention and control to consume either 750 mg of celery powder (obtained from fresh celery) or placebo along with a low‐calorie diet for 12 weeks, respectively. Dietary intake, physical activity, and cardiometabolic factors were assessed before and at the end of the study. Thirty‐six patients finished the study (18 in each group). Consumption of celery powder significantly reduced body fat percentage (p = .021). Between‐group analysis for changes in cardiometabolic factors did not show significant differences. Although malondialdehyde was reduced in the intervention group and increased in the control group, between‐group changes were not significant. Although the insulin‐level change was statistically insignificant, a clinical improvement was observed in the intervention group. A 750‐mg daily supplementation of celery powder for 12 weeks did not improve the cardiometabolic factors of patients with T2DM. Further studies are suggested.https://doi.org/10.1002/fsn3.3493Apium graveolensceleryhyperglycemiahyperlipidemiahypertensionweight loss |
| spellingShingle | Mohammad Ali Mohsenpour Mahsa Samadani Zeinab Shahsavani Mohammad Taghi Golmakani Gholam Reza Pishdad Maryam Ekramzadeh The effect of celery (Apium graveolens) powder on cardiometabolic factors in overweight/obese individuals with type 2 diabetes mellitus: A pilot randomized, double‐blinded, placebo‐controlled clinical trial Food Science & Nutrition Apium graveolens celery hyperglycemia hyperlipidemia hypertension weight loss |
| title | The effect of celery (Apium graveolens) powder on cardiometabolic factors in overweight/obese individuals with type 2 diabetes mellitus: A pilot randomized, double‐blinded, placebo‐controlled clinical trial |
| title_full | The effect of celery (Apium graveolens) powder on cardiometabolic factors in overweight/obese individuals with type 2 diabetes mellitus: A pilot randomized, double‐blinded, placebo‐controlled clinical trial |
| title_fullStr | The effect of celery (Apium graveolens) powder on cardiometabolic factors in overweight/obese individuals with type 2 diabetes mellitus: A pilot randomized, double‐blinded, placebo‐controlled clinical trial |
| title_full_unstemmed | The effect of celery (Apium graveolens) powder on cardiometabolic factors in overweight/obese individuals with type 2 diabetes mellitus: A pilot randomized, double‐blinded, placebo‐controlled clinical trial |
| title_short | The effect of celery (Apium graveolens) powder on cardiometabolic factors in overweight/obese individuals with type 2 diabetes mellitus: A pilot randomized, double‐blinded, placebo‐controlled clinical trial |
| title_sort | effect of celery apium graveolens powder on cardiometabolic factors in overweight obese individuals with type 2 diabetes mellitus a pilot randomized double blinded placebo controlled clinical trial |
| topic | Apium graveolens celery hyperglycemia hyperlipidemia hypertension weight loss |
| url | https://doi.org/10.1002/fsn3.3493 |
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