Frequency of multisite non-hand joint involvement in patients with thumb-base osteoarthritis, and associations with functional and patient-reported outcomes
Purpose: In OA studies, the focus often is on an index-joint; other affected joint sites are often overlooked. In this thumb-base OA study, we documented the frequency of symptomatic non-hand joint sites and investigated whether their count was associated with thumb-specific functional and patient-r...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Osteoarthritis and Cartilage Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266591312300064X |
| _version_ | 1827592895036653568 |
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| author | Anthony V. Perruccio Elizabeth M. Badley Daniel Antflek J Denise Power Heather Baltzer |
| author_facet | Anthony V. Perruccio Elizabeth M. Badley Daniel Antflek J Denise Power Heather Baltzer |
| author_sort | Anthony V. Perruccio |
| collection | DOAJ |
| description | Purpose: In OA studies, the focus often is on an index-joint; other affected joint sites are often overlooked. In this thumb-base OA study, we documented the frequency of symptomatic non-hand joint sites and investigated whether their count was associated with thumb-specific functional and patient-reported outcome measures. Design: Patients seeking care for thumb-base OA (conservative or surgical) were included. A patient-completed questionnaire captured sociodemographic and health characteristics, symptomatic hand and non-hand joint sites, and outcome measures (thumb-base pain intensity, symptoms and disability (TASD) and upper-extremity disability/symptoms (quickDASH)). Grip and pinch strength were measured. Linear regressions examined the association between each outcome and symptomatic joint site count, adjusted for several covariates. Results: The mean age of the 145 patients was 62 years, 72% were female. Mean symptomatic non-hand joint site count was 3.6. Ten percent reported only their hands as symptomatic; 30% reported 2–3 other symptomatic sites, and 49% reported 4+. From cross-sectional multivariable analyses, a higher symptomatic non-hand joint site count was associated with worse scores for all patient-reported outcomes and grip strength. Every unit increase in joint site count (49% had a 4+ count) was associated with a 2.1–3.3 unit increase (worse) in patient-reported outcome scores (all p < 0.02). Conclusions: In this sample, nearly 80% of patients had 2+ symptomatic non-hand joint sites. These symptoms were associated with worse thumb- and hand-specific outcomes, suggesting a need for awareness of whole body OA burden, with implications for outcome score interpretations, study designs, and provision of care in thumb-base OA. |
| first_indexed | 2024-03-09T02:02:20Z |
| format | Article |
| id | doaj.art-f7bbf2d3f58e45c08384a2e6c573454e |
| institution | Directory Open Access Journal |
| issn | 2665-9131 |
| language | English |
| last_indexed | 2024-03-09T02:02:20Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Osteoarthritis and Cartilage Open |
| spelling | doaj.art-f7bbf2d3f58e45c08384a2e6c573454e2023-12-08T04:46:06ZengElsevierOsteoarthritis and Cartilage Open2665-91312023-12-0154100397Frequency of multisite non-hand joint involvement in patients with thumb-base osteoarthritis, and associations with functional and patient-reported outcomesAnthony V. Perruccio0Elizabeth M. Badley1Daniel Antflek2J Denise Power3Heather Baltzer4Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Canada; Arthritis Community Research and Epidemiology Unit (ACREU), Canada; Institute of Health Policy, Management & Evaluation, Dalla Lana School of Public Health, University of Toronto, Canada; Department of Surgery, Faculty of Medicine, University of Toronto, Canada; Corresponding author. Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Canada.Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Canada; Arthritis Community Research and Epidemiology Unit (ACREU), Canada; Dalla Lana School of Public Health, University of Toronto, CanadaSchroeder Arthritis Institute, Krembil Research Institute, University Health Network, CanadaSchroeder Arthritis Institute, Krembil Research Institute, University Health Network, CanadaSchroeder Arthritis Institute, Krembil Research Institute, University Health Network, Canada; Department of Surgery, Faculty of Medicine, University of Toronto, CanadaPurpose: In OA studies, the focus often is on an index-joint; other affected joint sites are often overlooked. In this thumb-base OA study, we documented the frequency of symptomatic non-hand joint sites and investigated whether their count was associated with thumb-specific functional and patient-reported outcome measures. Design: Patients seeking care for thumb-base OA (conservative or surgical) were included. A patient-completed questionnaire captured sociodemographic and health characteristics, symptomatic hand and non-hand joint sites, and outcome measures (thumb-base pain intensity, symptoms and disability (TASD) and upper-extremity disability/symptoms (quickDASH)). Grip and pinch strength were measured. Linear regressions examined the association between each outcome and symptomatic joint site count, adjusted for several covariates. Results: The mean age of the 145 patients was 62 years, 72% were female. Mean symptomatic non-hand joint site count was 3.6. Ten percent reported only their hands as symptomatic; 30% reported 2–3 other symptomatic sites, and 49% reported 4+. From cross-sectional multivariable analyses, a higher symptomatic non-hand joint site count was associated with worse scores for all patient-reported outcomes and grip strength. Every unit increase in joint site count (49% had a 4+ count) was associated with a 2.1–3.3 unit increase (worse) in patient-reported outcome scores (all p < 0.02). Conclusions: In this sample, nearly 80% of patients had 2+ symptomatic non-hand joint sites. These symptoms were associated with worse thumb- and hand-specific outcomes, suggesting a need for awareness of whole body OA burden, with implications for outcome score interpretations, study designs, and provision of care in thumb-base OA.http://www.sciencedirect.com/science/article/pii/S266591312300064XThumb-base osteoarthritisMultijoint symptomsPainDisabilityGrip strengthPatient-reported outcomes |
| spellingShingle | Anthony V. Perruccio Elizabeth M. Badley Daniel Antflek J Denise Power Heather Baltzer Frequency of multisite non-hand joint involvement in patients with thumb-base osteoarthritis, and associations with functional and patient-reported outcomes Osteoarthritis and Cartilage Open Thumb-base osteoarthritis Multijoint symptoms Pain Disability Grip strength Patient-reported outcomes |
| title | Frequency of multisite non-hand joint involvement in patients with thumb-base osteoarthritis, and associations with functional and patient-reported outcomes |
| title_full | Frequency of multisite non-hand joint involvement in patients with thumb-base osteoarthritis, and associations with functional and patient-reported outcomes |
| title_fullStr | Frequency of multisite non-hand joint involvement in patients with thumb-base osteoarthritis, and associations with functional and patient-reported outcomes |
| title_full_unstemmed | Frequency of multisite non-hand joint involvement in patients with thumb-base osteoarthritis, and associations with functional and patient-reported outcomes |
| title_short | Frequency of multisite non-hand joint involvement in patients with thumb-base osteoarthritis, and associations with functional and patient-reported outcomes |
| title_sort | frequency of multisite non hand joint involvement in patients with thumb base osteoarthritis and associations with functional and patient reported outcomes |
| topic | Thumb-base osteoarthritis Multijoint symptoms Pain Disability Grip strength Patient-reported outcomes |
| url | http://www.sciencedirect.com/science/article/pii/S266591312300064X |
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