Co-treatment of nicotinamide mononucleotide and neoagarooligosaccharide mitigates aging-induced cognitive impairment by promoting mitochondrial dynamics
The synergistic effects of nicotinamide mononucleotide (NMN) and neoagarooligosaccharides (NAOS) on mitochondrial dysfunction, downstream apoptosis, and inflammation were evaluated in both senescence-accelerated mouse prone 8 (SAMP8) mice and H2O2-induced human lung fibroblast (MRC-5) cells. Co-trea...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623005224 |
| _version_ | 1827382595851124736 |
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| author | Tao Li Yanxiao Li Qiaojuan Yan Zhengqiang Jiang Shaoqing Yang |
| author_facet | Tao Li Yanxiao Li Qiaojuan Yan Zhengqiang Jiang Shaoqing Yang |
| author_sort | Tao Li |
| collection | DOAJ |
| description | The synergistic effects of nicotinamide mononucleotide (NMN) and neoagarooligosaccharides (NAOS) on mitochondrial dysfunction, downstream apoptosis, and inflammation were evaluated in both senescence-accelerated mouse prone 8 (SAMP8) mice and H2O2-induced human lung fibroblast (MRC-5) cells. Co-treatment of NMN and NAOS effectively ameliorated the learning and memory impairment in the passive avoidance and the Morris water maze tests. MNN and NAOS supplementation increased the expression levels of mitochondrial fusion proteins in the brain of SAMP8 mice, including OPA1 (by 37.4%) and Mitofusin 2 (by 99.7%). Moreover, co-treatment of NMN and NAOS significantly inhibited cell apoptosis as shown by the reduced protein expression levels of Bax and Caspase-3, down-regulated P53/P21/P16 pathway in both SAMP8 mice and H2O2-induced MRC-5 cells. At the same time, dietary intervention of NMN combined with NAOS attenuated the inflammatory response via down-regulating TLR4/MyD88/NF-κB pathway. Conclusively, the synergistic efficacy of the combination of NMN and NAOS can improve cognitive impairment by modulating mitochondrial dysfunction. |
| first_indexed | 2024-03-08T14:22:47Z |
| format | Article |
| id | doaj.art-f7bc50b4e0194eb6813e0b10353ae87e |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-08T14:22:47Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-f7bc50b4e0194eb6813e0b10353ae87e2024-01-14T05:37:10ZengElsevierJournal of Functional Foods1756-46462024-01-01112105922Co-treatment of nicotinamide mononucleotide and neoagarooligosaccharide mitigates aging-induced cognitive impairment by promoting mitochondrial dynamicsTao Li0Yanxiao Li1Qiaojuan Yan2Zhengqiang Jiang3Shaoqing Yang4Key Laboratory of Food Bioengineering (China National Light Industry), College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Science), Jinan 250014, ChinaDepartment of Nutrition and Health, College of Engineering, China Agricultural University, Beijing 100083, ChinaDepartment of Nutrition and Health, College of Engineering, China Agricultural University, Beijing 100083, ChinaKey Laboratory of Food Bioengineering (China National Light Industry), College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; Food Laboratory of Zhongyuan, Luohe 462300, ChinaKey Laboratory of Food Bioengineering (China National Light Industry), College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; Corresponding author.The synergistic effects of nicotinamide mononucleotide (NMN) and neoagarooligosaccharides (NAOS) on mitochondrial dysfunction, downstream apoptosis, and inflammation were evaluated in both senescence-accelerated mouse prone 8 (SAMP8) mice and H2O2-induced human lung fibroblast (MRC-5) cells. Co-treatment of NMN and NAOS effectively ameliorated the learning and memory impairment in the passive avoidance and the Morris water maze tests. MNN and NAOS supplementation increased the expression levels of mitochondrial fusion proteins in the brain of SAMP8 mice, including OPA1 (by 37.4%) and Mitofusin 2 (by 99.7%). Moreover, co-treatment of NMN and NAOS significantly inhibited cell apoptosis as shown by the reduced protein expression levels of Bax and Caspase-3, down-regulated P53/P21/P16 pathway in both SAMP8 mice and H2O2-induced MRC-5 cells. At the same time, dietary intervention of NMN combined with NAOS attenuated the inflammatory response via down-regulating TLR4/MyD88/NF-κB pathway. Conclusively, the synergistic efficacy of the combination of NMN and NAOS can improve cognitive impairment by modulating mitochondrial dysfunction.http://www.sciencedirect.com/science/article/pii/S1756464623005224AgingNicotinamide mononucleotideNeoagarooligosaccharidesCognitive impairmentMitochondrial dysfunction |
| spellingShingle | Tao Li Yanxiao Li Qiaojuan Yan Zhengqiang Jiang Shaoqing Yang Co-treatment of nicotinamide mononucleotide and neoagarooligosaccharide mitigates aging-induced cognitive impairment by promoting mitochondrial dynamics Journal of Functional Foods Aging Nicotinamide mononucleotide Neoagarooligosaccharides Cognitive impairment Mitochondrial dysfunction |
| title | Co-treatment of nicotinamide mononucleotide and neoagarooligosaccharide mitigates aging-induced cognitive impairment by promoting mitochondrial dynamics |
| title_full | Co-treatment of nicotinamide mononucleotide and neoagarooligosaccharide mitigates aging-induced cognitive impairment by promoting mitochondrial dynamics |
| title_fullStr | Co-treatment of nicotinamide mononucleotide and neoagarooligosaccharide mitigates aging-induced cognitive impairment by promoting mitochondrial dynamics |
| title_full_unstemmed | Co-treatment of nicotinamide mononucleotide and neoagarooligosaccharide mitigates aging-induced cognitive impairment by promoting mitochondrial dynamics |
| title_short | Co-treatment of nicotinamide mononucleotide and neoagarooligosaccharide mitigates aging-induced cognitive impairment by promoting mitochondrial dynamics |
| title_sort | co treatment of nicotinamide mononucleotide and neoagarooligosaccharide mitigates aging induced cognitive impairment by promoting mitochondrial dynamics |
| topic | Aging Nicotinamide mononucleotide Neoagarooligosaccharides Cognitive impairment Mitochondrial dysfunction |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623005224 |
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