RU486 mitigates Hippocampal Pathology Following Status Epilepticus

RU486 mitigates Hippocampal Pathology Following Status Epilepticus

Status epilepticus induces rapid hyper-activation of the hypothalamo-pituitary-adrenocortical (HPA) axis. HPA axis hyperactivity results in excess exposure to high levels of circulating glucocorticoids, which are associated with neurotoxicity and depression-like behavior. These observations have led...

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Bibliographic Details
Main Authors: Aynara Chavez Wulsin, James P Herman, Steve C Danzer
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Neurology
Subjects:
Hippocampus
Mifepristone
Status Epilepticus
mossy cells
RU486
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00214/full

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