Microwave Assisted Synthesis of 4-Phenylquinazolin-2(1H)-one Derivatives that Inhibit Vasopressor Tonus in Rat Thoracic Aorta
Quinazolinones have pharmacological effects on vascular reactivity through different mechanisms. We synthesized 4-phenylquinazolin-2(1H)-one derivatives under microwave irradiation and tested them on the rat thoracic aorta. The prepared compounds <b>2a−2f</b> were obtained in a...
Main Authors: | Rafaela Teixeira, Talita Menengat, Gabriel Andrade, Bruno Cotrim, Cristiano Ponte, Wilson C. Santos, Gabriel Resende |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-03-01
|
Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/25/6/1467 |
Similar Items
-
Evaluation of Vasorlaxant Effect of Achillea Wilhelmsii Hydroalcholic Extract on Isolated Aorta in Rat
by: F Harandizadeh, et al.
Published: (2012-03-01) -
Endothelium-independent vasorelaxant activity of Trachyspermum ammi essential oil on rat aorta
by: G. Sargazi Zadeh, et al.
Published: (2017-02-01) -
Discovery of novel 4-phenylquinazoline-based BRD4 inhibitors for cardiac fibrosis
by: Zhangxu He, et al.
Published: (2022-01-01) -
Vasorelaxing effect of Garcinia cowa leaf extract in rat thoracic aorta and its underlying mechanisms
by: Somruedee Yorsin, et al.
Published: (2023-05-01) -
CT and MR imaging of the thoracic aorta
by: Di Cesare Ernesto, et al.
Published: (2016-01-01)