Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions
In this paper, an investigation into detecting immunosuppressive medicine in aqueous solutions using a spectrometry-based technique is described. Using optical transmissive spectrometry, absorbance measurements in the spectra range from 250 nm to 1000 nm were carried out for different cyclosporine A...
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| Format: | Article |
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MDPI AG
2018-06-01
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| Series: | Sensors |
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| Online Access: | http://www.mdpi.com/1424-8220/18/7/2001 |
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| author | Marcin Marzejon Monika Kosowska Daria Majchrowicz Barbara Bułło-Piontecka Michał Wąsowicz Małgorzata Jędrzejewska-Szczerska |
| author_facet | Marcin Marzejon Monika Kosowska Daria Majchrowicz Barbara Bułło-Piontecka Michał Wąsowicz Małgorzata Jędrzejewska-Szczerska |
| author_sort | Marcin Marzejon |
| collection | DOAJ |
| description | In this paper, an investigation into detecting immunosuppressive medicine in aqueous solutions using a spectrometry-based technique is described. Using optical transmissive spectrometry, absorbance measurements in the spectra range from 250 nm to 1000 nm were carried out for different cyclosporine A (CsA) concentrations in aqueous solutions. The experiment was conducted for samples both with and without interferent substances—glucose and sodium chloride. Using a dedicated algorithm, the measured data was analyzed and a high correlation coefficient R2 = 0.8647 was achieved. The experiment showed that the described technique allowed for the detection of various CsA concentration levels in a selective, label-free and simple way. This method could be used in medicine, veterinary medicine and laboratory diagnostics. |
| first_indexed | 2024-04-11T21:47:17Z |
| format | Article |
| id | doaj.art-f7bf334e8ceb41b7b8f95eb9b66bafed |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T21:47:17Z |
| publishDate | 2018-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-f7bf334e8ceb41b7b8f95eb9b66bafed2022-12-22T04:01:23ZengMDPI AGSensors1424-82202018-06-01187200110.3390/s18072001s18072001Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous SolutionsMarcin Marzejon0Monika Kosowska1Daria Majchrowicz2Barbara Bułło-Piontecka3Michał Wąsowicz4Małgorzata Jędrzejewska-Szczerska5Department of Metrology and Optoelectronics, Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, 11/12 Narutowicza Street, 80-233 Gdansk, PolandDepartment of Metrology and Optoelectronics, Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, 11/12 Narutowicza Street, 80-233 Gdansk, PolandDepartment of Metrology and Optoelectronics, Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, 11/12 Narutowicza Street, 80-233 Gdansk, PolandDepartment of Nephrology, Transplantology and Internal Diseases, Faculty of Medicine, Medical University of Gdańsk, 3a Marii Skłodowskiej-Curie Street, 80-210 Gdansk, PolandDepartment of Morphological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, 159 Nowoursynowska Street, 02-776 Warszawa, PolandDepartment of Metrology and Optoelectronics, Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, 11/12 Narutowicza Street, 80-233 Gdansk, PolandIn this paper, an investigation into detecting immunosuppressive medicine in aqueous solutions using a spectrometry-based technique is described. Using optical transmissive spectrometry, absorbance measurements in the spectra range from 250 nm to 1000 nm were carried out for different cyclosporine A (CsA) concentrations in aqueous solutions. The experiment was conducted for samples both with and without interferent substances—glucose and sodium chloride. Using a dedicated algorithm, the measured data was analyzed and a high correlation coefficient R2 = 0.8647 was achieved. The experiment showed that the described technique allowed for the detection of various CsA concentration levels in a selective, label-free and simple way. This method could be used in medicine, veterinary medicine and laboratory diagnostics.http://www.mdpi.com/1424-8220/18/7/2001optical spectrophotometrylabel-free detectioncyclosporine |
| spellingShingle | Marcin Marzejon Monika Kosowska Daria Majchrowicz Barbara Bułło-Piontecka Michał Wąsowicz Małgorzata Jędrzejewska-Szczerska Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions Sensors optical spectrophotometry label-free detection cyclosporine |
| title | Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions |
| title_full | Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions |
| title_fullStr | Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions |
| title_full_unstemmed | Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions |
| title_short | Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions |
| title_sort | optical spectrometry based method for immunosuppressant medicine level detection in aqueous solutions |
| topic | optical spectrophotometry label-free detection cyclosporine |
| url | http://www.mdpi.com/1424-8220/18/7/2001 |
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