Synthesis and Biological Evaluation of <sup>99m</sup>Tc(I) Tricarbonyl Complexes Dual-Targeted at Tumoral Mitochondria

Synthesis and Biological Evaluation of <sup>99m</sup>Tc(I) Tricarbonyl Complexes Dual-Targeted at Tumoral Mitochondria

For effective Auger therapy of cancer, the Auger-electron emitters must be delivered to the tumor cells in close proximity to a radiosensitive cellular target. Nuclear DNA is considered the most relevant target of Auger electrons to have augmented radiotoxic effects and significant cell death. Howev...

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Hlavní autoři: Diogo Figueiredo, Célia Fernandes, Francisco Silva, Elisa Palma, Paula Raposinho, Ana Belchior, Pedro Vaz, António Paulo
Médium: Článek
Jazyk:English
Vydáno: MDPI AG 2021-01-01
Edice:Molecules
Témata:
radiopharmaceuticals
auger emitters
technetium-99m
targeted radionuclide therapy (TRT)
mitochondria targeting
On-line přístup:https://www.mdpi.com/1420-3049/26/2/441

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https://www.mdpi.com/1420-3049/26/2/441

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