Treatment of Oligozoospermic Patients with a Formulation of Plant Origin (Speman)
Background: Assessment of sperm concentration as a component of semen analysis is one of the most important steps in the evaluation of male in infertile couples so that Oligozoospermia is a decrease in the numbers & density of spermatozoa produced by testes (˂ 20 mill/ml). Speman is formulatio...
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| Format: | Article |
| Language: | English |
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College of medicine/ University of Diyala
2019-11-01
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| Series: | Diyala Journal of Medicine |
| Subjects: | |
| Online Access: | http://djm.uodiyala.edu.iq/index.php/djm/article/view/408 |
| _version_ | 1827636473429491712 |
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| author | Hussain Khaleefa Kadhem Nawal Khairy Al-Ani |
| author_facet | Hussain Khaleefa Kadhem Nawal Khairy Al-Ani |
| author_sort | Hussain Khaleefa Kadhem |
| collection | DOAJ |
| description |
Background: Assessment of sperm concentration as a component of semen analysis is one of the most important steps in the evaluation of male in infertile couples so that Oligozoospermia is a decrease in the numbers & density of spermatozoa produced by testes (˂ 20 mill/ml). Speman is formulation of plant origin with no side effects and has been tried for oligozoospermia, asthenozoospermia, enlarged prostate and azoospermia
Objective: To assess the effect of speman on
1-Pituitary –gonadal hormones 2-On the certain sperm parameters
Patient and Methods: A prospective study was conducted on forty oligozoospermic patients attended the High Institute of Infertility Diagnosis and Assisted Reproductive Technologies/Al-Nahrain University for period between first September 2011 to September 2012 , the mean age 35 years and with duration of infertility ranged between 1.5—12 years.
The patients were considered oligozoospermic if the sperm concentration was less than 20 million/ml according to WHO 1999 criteria . Speman drug was administered at a dose of 2 tablets, three time daily for three months. Semen analysis , particularly certain sperm parameter( sperm density , motility and morphology) and Hormonal assay of serum levels of testosterone , Follicles stimulating and Luteinizing hormones was conducted before and after treatment .
Results: The results showed there was a highly significant (p˂0.001) which increase in the means of sperm density (19.90 million\ml) it was observed after 3months of Speman treatment. Regarding the sperm motility particularly grade-A was showed a significant(˂0.05) improvement (31.87%) after treatment, and grade-A+B were improved ( 50.27%) after treatment. The morphology of sperm was significantly (˂0.05) reduced (31.50% )after treatment . The mean serum level of testosterone and Luteinizing hormone were showed a significant (˂0.05) increased (6.24 ng\ml) and ( 3.98μIU/ml) after treatment respectively.
Regarding its effect on follicle stimulating hormone were about 22.5% of cases shows high serum level of FSH so that the speman , significantly (˂0.05) reduced follicle stimulating hormone (5.69 μIU/ml) after treatment i.e. decreasing serum level by negative feedback mechanism on hypo-thalamic-pituitary-testicular axis due to increase serum level of LH which in turn lead to increase testosterone that causes decreased serum level of FSH.
Conclusion: speman may improve the sperm density , motility and morphology due to improvement of testicular function and male accessory genital gland by influencing of testosterone hormone which caused the serum level of FSH to be normal through feedback mechansim and increasing serum level of LH.
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| first_indexed | 2024-03-09T15:43:23Z |
| format | Article |
| id | doaj.art-f7c616b7f32849d982bef81b7c39ae04 |
| institution | Directory Open Access Journal |
| issn | 2219-9764 2617-8982 |
| language | English |
| last_indexed | 2024-03-09T15:43:23Z |
| publishDate | 2019-11-01 |
| publisher | College of medicine/ University of Diyala |
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| series | Diyala Journal of Medicine |
| spelling | doaj.art-f7c616b7f32849d982bef81b7c39ae042023-11-24T23:23:39ZengCollege of medicine/ University of DiyalaDiyala Journal of Medicine2219-97642617-89822019-11-0141Treatment of Oligozoospermic Patients with a Formulation of Plant Origin (Speman)Hussain Khaleefa Kadhem Nawal Khairy Al-Ani Background: Assessment of sperm concentration as a component of semen analysis is one of the most important steps in the evaluation of male in infertile couples so that Oligozoospermia is a decrease in the numbers & density of spermatozoa produced by testes (˂ 20 mill/ml). Speman is formulation of plant origin with no side effects and has been tried for oligozoospermia, asthenozoospermia, enlarged prostate and azoospermia Objective: To assess the effect of speman on 1-Pituitary –gonadal hormones 2-On the certain sperm parameters Patient and Methods: A prospective study was conducted on forty oligozoospermic patients attended the High Institute of Infertility Diagnosis and Assisted Reproductive Technologies/Al-Nahrain University for period between first September 2011 to September 2012 , the mean age 35 years and with duration of infertility ranged between 1.5—12 years. The patients were considered oligozoospermic if the sperm concentration was less than 20 million/ml according to WHO 1999 criteria . Speman drug was administered at a dose of 2 tablets, three time daily for three months. Semen analysis , particularly certain sperm parameter( sperm density , motility and morphology) and Hormonal assay of serum levels of testosterone , Follicles stimulating and Luteinizing hormones was conducted before and after treatment . Results: The results showed there was a highly significant (p˂0.001) which increase in the means of sperm density (19.90 million\ml) it was observed after 3months of Speman treatment. Regarding the sperm motility particularly grade-A was showed a significant(˂0.05) improvement (31.87%) after treatment, and grade-A+B were improved ( 50.27%) after treatment. The morphology of sperm was significantly (˂0.05) reduced (31.50% )after treatment . The mean serum level of testosterone and Luteinizing hormone were showed a significant (˂0.05) increased (6.24 ng\ml) and ( 3.98μIU/ml) after treatment respectively. Regarding its effect on follicle stimulating hormone were about 22.5% of cases shows high serum level of FSH so that the speman , significantly (˂0.05) reduced follicle stimulating hormone (5.69 μIU/ml) after treatment i.e. decreasing serum level by negative feedback mechanism on hypo-thalamic-pituitary-testicular axis due to increase serum level of LH which in turn lead to increase testosterone that causes decreased serum level of FSH. Conclusion: speman may improve the sperm density , motility and morphology due to improvement of testicular function and male accessory genital gland by influencing of testosterone hormone which caused the serum level of FSH to be normal through feedback mechansim and increasing serum level of LH. http://djm.uodiyala.edu.iq/index.php/djm/article/view/408Oligozoospermia,Speman,Semina fluid,serum Testosteron, LH FSH |
| spellingShingle | Hussain Khaleefa Kadhem Nawal Khairy Al-Ani Treatment of Oligozoospermic Patients with a Formulation of Plant Origin (Speman) Diyala Journal of Medicine Oligozoospermia,Speman,Semina fluid,serum Testosteron, LH FSH |
| title | Treatment of Oligozoospermic Patients with a Formulation of Plant Origin (Speman) |
| title_full | Treatment of Oligozoospermic Patients with a Formulation of Plant Origin (Speman) |
| title_fullStr | Treatment of Oligozoospermic Patients with a Formulation of Plant Origin (Speman) |
| title_full_unstemmed | Treatment of Oligozoospermic Patients with a Formulation of Plant Origin (Speman) |
| title_short | Treatment of Oligozoospermic Patients with a Formulation of Plant Origin (Speman) |
| title_sort | treatment of oligozoospermic patients with a formulation of plant origin speman |
| topic | Oligozoospermia,Speman,Semina fluid,serum Testosteron, LH FSH |
| url | http://djm.uodiyala.edu.iq/index.php/djm/article/view/408 |
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