Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment
Despite a large number of therapeutic options available, malignant melanoma remains a highly fatal disease, especially in its metastatic forms. The oncogenic role of protein tyrosine phosphatases (PTPs) is becoming increasingly clear, paving the way for novel antitumor treatments based on their inhi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/10/2799 |
| _version_ | 1797552322947055616 |
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| author | Elisa Pardella Erica Pranzini Angela Leo Maria Letizia Taddei Paolo Paoli Giovanni Raugei |
| author_facet | Elisa Pardella Erica Pranzini Angela Leo Maria Letizia Taddei Paolo Paoli Giovanni Raugei |
| author_sort | Elisa Pardella |
| collection | DOAJ |
| description | Despite a large number of therapeutic options available, malignant melanoma remains a highly fatal disease, especially in its metastatic forms. The oncogenic role of protein tyrosine phosphatases (PTPs) is becoming increasingly clear, paving the way for novel antitumor treatments based on their inhibition. In this review, we present the oncogenic PTPs contributing to melanoma progression and we provide, where available, a description of new inhibitory strategies designed against these enzymes and possibly useful in melanoma treatment. Considering the relevance of the immune infiltrate in supporting melanoma progression, we also focus on the role of PTPs in modulating immune cell activity, identifying interesting therapeutic options that may support the currently applied immunomodulating approaches. Collectively, this information highlights the value of going further in the development of new strategies targeting oncogenic PTPs to improve the efficacy of melanoma treatment. |
| first_indexed | 2024-03-10T15:58:23Z |
| format | Article |
| id | doaj.art-f7c625ab32304ac4bf26fbb6a3c494fb |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T15:58:23Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-f7c625ab32304ac4bf26fbb6a3c494fb2023-11-20T15:31:08ZengMDPI AGCancers2072-66942020-09-011210279910.3390/cancers12102799Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma TreatmentElisa Pardella0Erica Pranzini1Angela Leo2Maria Letizia Taddei3Paolo Paoli4Giovanni Raugei5Department of Experimental and Clinical Biomedical Sciences “Mario Serio” University of Florence, Viale Morgagni 50, 50134 Florence, ItalyDepartment of Experimental and Clinical Biomedical Sciences “Mario Serio” University of Florence, Viale Morgagni 50, 50134 Florence, ItalyDepartment of Experimental and Clinical Biomedical Sciences “Mario Serio” University of Florence, Viale Morgagni 50, 50134 Florence, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, Viale Morgagni 50, 50134 Florence, ItalyDepartment of Experimental and Clinical Biomedical Sciences “Mario Serio” University of Florence, Viale Morgagni 50, 50134 Florence, ItalyDepartment of Experimental and Clinical Biomedical Sciences “Mario Serio” University of Florence, Viale Morgagni 50, 50134 Florence, ItalyDespite a large number of therapeutic options available, malignant melanoma remains a highly fatal disease, especially in its metastatic forms. The oncogenic role of protein tyrosine phosphatases (PTPs) is becoming increasingly clear, paving the way for novel antitumor treatments based on their inhibition. In this review, we present the oncogenic PTPs contributing to melanoma progression and we provide, where available, a description of new inhibitory strategies designed against these enzymes and possibly useful in melanoma treatment. Considering the relevance of the immune infiltrate in supporting melanoma progression, we also focus on the role of PTPs in modulating immune cell activity, identifying interesting therapeutic options that may support the currently applied immunomodulating approaches. Collectively, this information highlights the value of going further in the development of new strategies targeting oncogenic PTPs to improve the efficacy of melanoma treatment.https://www.mdpi.com/2072-6694/12/10/2799melanomaprotein tyrosine phosphatasePTPs inhibitorsmelanoma immune infiltrate |
| spellingShingle | Elisa Pardella Erica Pranzini Angela Leo Maria Letizia Taddei Paolo Paoli Giovanni Raugei Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment Cancers melanoma protein tyrosine phosphatase PTPs inhibitors melanoma immune infiltrate |
| title | Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment |
| title_full | Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment |
| title_fullStr | Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment |
| title_full_unstemmed | Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment |
| title_short | Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment |
| title_sort | oncogenic tyrosine phosphatases novel therapeutic targets for melanoma treatment |
| topic | melanoma protein tyrosine phosphatase PTPs inhibitors melanoma immune infiltrate |
| url | https://www.mdpi.com/2072-6694/12/10/2799 |
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