Investigating the prevalence of primary thyroid dysfunction in obese and overweight individuals: Tehran thyroid study
Abstract Background Due to the increasing worldwide prevalence of obesity, it is essential to determine the prevalence of obesity-related thyroid dysfunctions. The purpose of this study was to investigate the prevalence of thyroid dysfunctions, namely hypothyroidism and hyperthyroidism, and their as...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-04-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-021-00743-4 |
| _version_ | 1830090710827663360 |
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| author | Mahdi Mahdavi Atieh Amouzegar Ladan Mehran Elham Madreseh Maryam Tohidi Fereidoun Azizi |
| author_facet | Mahdi Mahdavi Atieh Amouzegar Ladan Mehran Elham Madreseh Maryam Tohidi Fereidoun Azizi |
| author_sort | Mahdi Mahdavi |
| collection | DOAJ |
| description | Abstract Background Due to the increasing worldwide prevalence of obesity, it is essential to determine the prevalence of obesity-related thyroid dysfunctions. The purpose of this study was to investigate the prevalence of thyroid dysfunctions, namely hypothyroidism and hyperthyroidism, and their association with BMI among adult Iranian overweight and obese individuals. Method This cross-sectional study was carried out within the framework of the Tehran Thyroid Study (TTS); 5353 participants (57.5% female) entered our study. Anthropometric measurements were performed. Serum levels of thyroid-stimulating hormone (TSH), free thyroxine (FT4), and thyroid peroxidase antibody (TPOAb) were assayed. We categorized individuals into 3 BMI groups (normal-weight, overweight and obese), then calculated prevalence rate, odds ratio (OR), and 95% confidence interval (CI) for outcomes in overweight and obese groups. The normal-weight group was used as the control group. Results We found a higher prevalence of hypothyroidism (11.6% vs 8.2% Total, 4.0% vs 1.1% overt and 7.6% vs 7.1% subclinical, P < 0.001) and TPOAb positivity (17.3% vs 11.6%, P < 0.001) in obese participants compared with normal-weight participants. Hyperthyroidism’s overall prevalence was 4.2, 5.7, and 4.9% in obese, overweight, and normal-weight groups, respectively. Obesity was associated with higher odds of overt hypothyroidism (OR: 2.0, 95% CI: 1.15–3.49, P < 0.05) and TPOAb positivity (OR: 1.29, 95% CI: 1.04–1.60, P < 0.05) after adjusting for confounding variables. In contrast, no association was observed between the overweight group and the odds of hypothyroidism and TPOAb positivity in the adjusted results. Conclusions Obesity was associated with an increased risk of overt hypothyroidism and TPOAb positivity. |
| first_indexed | 2024-12-16T17:07:22Z |
| format | Article |
| id | doaj.art-f7c8e71ba71149babe2c811c16c62601 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-12-16T17:07:22Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-f7c8e71ba71149babe2c811c16c626012022-12-21T22:23:32ZengBMCBMC Endocrine Disorders1472-68232021-04-0121111210.1186/s12902-021-00743-4Investigating the prevalence of primary thyroid dysfunction in obese and overweight individuals: Tehran thyroid studyMahdi Mahdavi0Atieh Amouzegar1Ladan Mehran2Elham Madreseh3Maryam Tohidi4Fereidoun Azizi5Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesEndocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesEndocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesEndocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesPrevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesEndocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesAbstract Background Due to the increasing worldwide prevalence of obesity, it is essential to determine the prevalence of obesity-related thyroid dysfunctions. The purpose of this study was to investigate the prevalence of thyroid dysfunctions, namely hypothyroidism and hyperthyroidism, and their association with BMI among adult Iranian overweight and obese individuals. Method This cross-sectional study was carried out within the framework of the Tehran Thyroid Study (TTS); 5353 participants (57.5% female) entered our study. Anthropometric measurements were performed. Serum levels of thyroid-stimulating hormone (TSH), free thyroxine (FT4), and thyroid peroxidase antibody (TPOAb) were assayed. We categorized individuals into 3 BMI groups (normal-weight, overweight and obese), then calculated prevalence rate, odds ratio (OR), and 95% confidence interval (CI) for outcomes in overweight and obese groups. The normal-weight group was used as the control group. Results We found a higher prevalence of hypothyroidism (11.6% vs 8.2% Total, 4.0% vs 1.1% overt and 7.6% vs 7.1% subclinical, P < 0.001) and TPOAb positivity (17.3% vs 11.6%, P < 0.001) in obese participants compared with normal-weight participants. Hyperthyroidism’s overall prevalence was 4.2, 5.7, and 4.9% in obese, overweight, and normal-weight groups, respectively. Obesity was associated with higher odds of overt hypothyroidism (OR: 2.0, 95% CI: 1.15–3.49, P < 0.05) and TPOAb positivity (OR: 1.29, 95% CI: 1.04–1.60, P < 0.05) after adjusting for confounding variables. In contrast, no association was observed between the overweight group and the odds of hypothyroidism and TPOAb positivity in the adjusted results. Conclusions Obesity was associated with an increased risk of overt hypothyroidism and TPOAb positivity.https://doi.org/10.1186/s12902-021-00743-4ObesityOverweightThyroid dysfunctionTehran thyroid studyHypothyroidism |
| spellingShingle | Mahdi Mahdavi Atieh Amouzegar Ladan Mehran Elham Madreseh Maryam Tohidi Fereidoun Azizi Investigating the prevalence of primary thyroid dysfunction in obese and overweight individuals: Tehran thyroid study BMC Endocrine Disorders Obesity Overweight Thyroid dysfunction Tehran thyroid study Hypothyroidism |
| title | Investigating the prevalence of primary thyroid dysfunction in obese and overweight individuals: Tehran thyroid study |
| title_full | Investigating the prevalence of primary thyroid dysfunction in obese and overweight individuals: Tehran thyroid study |
| title_fullStr | Investigating the prevalence of primary thyroid dysfunction in obese and overweight individuals: Tehran thyroid study |
| title_full_unstemmed | Investigating the prevalence of primary thyroid dysfunction in obese and overweight individuals: Tehran thyroid study |
| title_short | Investigating the prevalence of primary thyroid dysfunction in obese and overweight individuals: Tehran thyroid study |
| title_sort | investigating the prevalence of primary thyroid dysfunction in obese and overweight individuals tehran thyroid study |
| topic | Obesity Overweight Thyroid dysfunction Tehran thyroid study Hypothyroidism |
| url | https://doi.org/10.1186/s12902-021-00743-4 |
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