Impact of Physical Activity and Natural Bioactive Compounds on Endothelial Dysfunction in Chronic Kidney Disease
Chronic kidney disease (CKD) represents a world-wide public health problem. Inflammation, endothelial dysfunction (ED) and vascular calcifications are clinical features of CKD patients that increase cardiovascular (CV) mortality. CKD-related CV disease pathogenic mechanisms are not only associated w...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/11/8/841 |
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| author | Elisa Grazioli Annalisa Romani Giulia Marrone Manuela Di Lauro Claudia Cerulli Silvia Urciuoli Arianna Murri Cristina Guerriero Eliana Tranchita Manfredi Tesauro Attilio Parisi Nicola Di Daniele Annalisa Noce |
| author_facet | Elisa Grazioli Annalisa Romani Giulia Marrone Manuela Di Lauro Claudia Cerulli Silvia Urciuoli Arianna Murri Cristina Guerriero Eliana Tranchita Manfredi Tesauro Attilio Parisi Nicola Di Daniele Annalisa Noce |
| author_sort | Elisa Grazioli |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) represents a world-wide public health problem. Inflammation, endothelial dysfunction (ED) and vascular calcifications are clinical features of CKD patients that increase cardiovascular (CV) mortality. CKD-related CV disease pathogenic mechanisms are not only associated with traditional factors such as arterial hypertension and dyslipidemia, but also with ED, oxidative stress and low-grade inflammation. The typical comorbidities of CKD contribute to reduce the performance and the levels of the physical activity in nephropathic patients compared to healthy subjects. Currently, the effective role of physical activity on ED is still debated, but the available few literature data suggest its positive contribution. Another possible adjuvant treatment of ED in CKD patients is represented by natural bioactive compounds (NBCs). Among these, minor polar compounds of extra virgin olive oil (hydroxytyrosol, tyrosol and oleocanthal), polyphenols, and vitamin D seem to exert a beneficial role on ED in CKD patients. The objective of the review is to evaluate the effectiveness of physical exercise protocols and/or NBCs on ED in CKD patients. |
| first_indexed | 2024-03-10T08:40:34Z |
| format | Article |
| id | doaj.art-f7c953c64c884481b6a98fe7ac616ad5 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T08:40:34Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-f7c953c64c884481b6a98fe7ac616ad52023-11-22T08:23:41ZengMDPI AGLife2075-17292021-08-0111884110.3390/life11080841Impact of Physical Activity and Natural Bioactive Compounds on Endothelial Dysfunction in Chronic Kidney DiseaseElisa Grazioli0Annalisa Romani1Giulia Marrone2Manuela Di Lauro3Claudia Cerulli4Silvia Urciuoli5Arianna Murri6Cristina Guerriero7Eliana Tranchita8Manfredi Tesauro9Attilio Parisi10Nicola Di Daniele11Annalisa Noce12Department of Exercise, Human and Health Sciences, Foro Italico University of Rome, 00135 Rome, ItalyPHYTOLAB (Pharmaceutical, Cosmetic, Food Supplement, Technology and Analysis), DiSIA, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, ItalyUOC of Internal Medicine—Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, ItalyUOC of Internal Medicine—Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, ItalyDepartment of Exercise, Human and Health Sciences, Foro Italico University of Rome, 00135 Rome, ItalyPHYTOLAB (Pharmaceutical, Cosmetic, Food Supplement, Technology and Analysis), DiSIA, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, ItalyDepartment of Exercise, Human and Health Sciences, Foro Italico University of Rome, 00135 Rome, ItalyUOC of Internal Medicine—Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, ItalyDepartment of Exercise, Human and Health Sciences, Foro Italico University of Rome, 00135 Rome, ItalyUOC of Internal Medicine—Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, ItalyDepartment of Exercise, Human and Health Sciences, Foro Italico University of Rome, 00135 Rome, ItalyUOC of Internal Medicine—Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, ItalyUOC of Internal Medicine—Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, ItalyChronic kidney disease (CKD) represents a world-wide public health problem. Inflammation, endothelial dysfunction (ED) and vascular calcifications are clinical features of CKD patients that increase cardiovascular (CV) mortality. CKD-related CV disease pathogenic mechanisms are not only associated with traditional factors such as arterial hypertension and dyslipidemia, but also with ED, oxidative stress and low-grade inflammation. The typical comorbidities of CKD contribute to reduce the performance and the levels of the physical activity in nephropathic patients compared to healthy subjects. Currently, the effective role of physical activity on ED is still debated, but the available few literature data suggest its positive contribution. Another possible adjuvant treatment of ED in CKD patients is represented by natural bioactive compounds (NBCs). Among these, minor polar compounds of extra virgin olive oil (hydroxytyrosol, tyrosol and oleocanthal), polyphenols, and vitamin D seem to exert a beneficial role on ED in CKD patients. The objective of the review is to evaluate the effectiveness of physical exercise protocols and/or NBCs on ED in CKD patients.https://www.mdpi.com/2075-1729/11/8/841cardiovascular diseasechronic kidney diseaseendothelial dysfunctionendotheliumnatural bioactive compoundsasymmetrical dimethylarginine |
| spellingShingle | Elisa Grazioli Annalisa Romani Giulia Marrone Manuela Di Lauro Claudia Cerulli Silvia Urciuoli Arianna Murri Cristina Guerriero Eliana Tranchita Manfredi Tesauro Attilio Parisi Nicola Di Daniele Annalisa Noce Impact of Physical Activity and Natural Bioactive Compounds on Endothelial Dysfunction in Chronic Kidney Disease Life cardiovascular disease chronic kidney disease endothelial dysfunction endothelium natural bioactive compounds asymmetrical dimethylarginine |
| title | Impact of Physical Activity and Natural Bioactive Compounds on Endothelial Dysfunction in Chronic Kidney Disease |
| title_full | Impact of Physical Activity and Natural Bioactive Compounds on Endothelial Dysfunction in Chronic Kidney Disease |
| title_fullStr | Impact of Physical Activity and Natural Bioactive Compounds on Endothelial Dysfunction in Chronic Kidney Disease |
| title_full_unstemmed | Impact of Physical Activity and Natural Bioactive Compounds on Endothelial Dysfunction in Chronic Kidney Disease |
| title_short | Impact of Physical Activity and Natural Bioactive Compounds on Endothelial Dysfunction in Chronic Kidney Disease |
| title_sort | impact of physical activity and natural bioactive compounds on endothelial dysfunction in chronic kidney disease |
| topic | cardiovascular disease chronic kidney disease endothelial dysfunction endothelium natural bioactive compounds asymmetrical dimethylarginine |
| url | https://www.mdpi.com/2075-1729/11/8/841 |
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