Evaluation of C-Reactive Protein and Fibrinogen in Patients with Chronic and Aggressive Periodontitis: A Clinico-Biochemical Study
Introduction: Periodontal disease is characterised by chronic infection and inflammation in periodontal tissues leading to destruction of alveolar bone with subsequent tooth loss. Periodontal infections are the result of an interaction between tooth associated microbial biofilms and the host def...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/9552/23100_CE(RA1)_F(T)_PF1(PrG_RK)_PFA(RK)_PF2(P_NESY).pdf |
| Summary: | Introduction: Periodontal disease is characterised by chronic
infection and inflammation in periodontal tissues leading
to destruction of alveolar bone with subsequent tooth loss.
Periodontal infections are the result of an interaction between
tooth associated microbial biofilms and the host defences.
Periodontal pathogens can affect local and systemic immune
and inflammatory responses.
Aim: The aim of the present study was to evaluate serum
C-Reactive Protein (CRP), plasma fibrinogen and peripheral blood
levels in healthy subjects, chronic and aggressive periodontitis
patients.
Materials and Methods: A total of 55 subjects, 27 males and
28 females were selected for the study. Blood samples were
taken from healthy controls (n=20) and patients with chronic
periodontitis (n=20) and aggressive periodontitis (n=15). The
periodontal status of each patient was assessed by recording
Oral Hygiene Index-Simplified (OHI-S), Bleeding Index (BI),
Probing Pocket Depth (PPD) and Clinical Attachment Level
(CAL). The levels of serum CRP were measured using high
sensitivity Enzyme Linked Immunosorbent Assay (ELISA) and
levels of plasma fibrinogen were measured using Quantitative
Immunoturbidimetric assay. Data description was done in the
form of mean and standard deviation and analysis of data was
done using one way ANOVA (Analysis of Variance) and Students
t-test to test the statistical significance between groups.
Results: The levels of serum CRP and plasma fibrinogen was
increased in patients with chronic and aggressive periodontitis
when compared to healthy controls (p<0.001). A positive
correlation was found to exist between levels of clinical
parameters like OHI-S, BI, PPD and CAL when compared with
CRP and fibrinogen as well as with the study groups.
Conclusion: The finding of the present study suggests the role
of serum as a diagnostic marker in inflammatory conditions
and indicates that levels of CRP and fibrinogen may serve as
important biomarkers for evaluating the association between
periodontitis and cardiovascular diseases. |
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| ISSN: | 2249-782X 0973-709X |